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Ophthalmology General

Normative patterns and factors associated with presbyopia progression in a multiethnic Asian population: the Singapore Epidemiology of Eye Diseases Study

Dec 08, 2020

Researchers conducted this research to investigate normative patterns and factors associated with presbyopia progression in a multiethnic Asian population. Malay, Indian and Chinese participants who ...

COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage.

Dec 07, 2020

Leber congenital amaurosis (LCA), a form of autosomal recessive severe early-onset retinal degeneration, is an important cause of childhood blindness. This may be associated with systemic features or ...

Construction of a knowledge graph for diabetes complications from expert-reviewed clinical evidences.

Dec 07, 2020

A knowledge graph is a structured representation of data that can express entity and relational knowledge. More attention has been paid to the study of a clinical knowledge graph, especially in the fi...

Altered Expression of GJD2 Messenger RNA and the Coded Protein Connexin 36 in Negative Lens-induced Myopia of Guinea Pigs.

Dec 07, 2020

Decreased expression of the retinal GJD2 gene messenger RNA (mRNA) and connexin 36 (Cx36) protein in the guinea pig negative lens-induced myopia (LIM) model suggests their involvement in local retinal...

PROSPECTIVE CLINICAL EVALUATION OF THE EFFECTIVENESS OF ASYMMETRIC INTRACORNEAL RING WITH VARIABLE THICKNESS AND WIDTH FOR THE MANAGEMENT OF KERATOCONUS.

Dec 07, 2020

To evaluate the short-term clinical outcomes obtained with a new model of asymmetric intracorneal ring segments (ICRS) with variable thickness and base width in keratoconus.Four Spanish ophthalmologic...

Evaluation of Four Artificial Intelligence-Assisted Self-Diagnosis Apps on Three Diagnoses: Two-Year Follow-Up Study.

Dec 07, 2020

Consumer-oriented mobile self-diagnosis apps have been developed using undisclosed algorithms, presumably based on machine learning and other artificial intelligence (AI) technologies. The US Food and...

The spectrum of allergic ocular diseases-2020.

Dec 07, 2020

The purpose of this paper is to review the pathophysiologic mechanisms, differential diagnosis, evaluation and treatment of the various manifestations of ocular allergy, with an especial focus on IgE-...

Rheological behavior of commercial artificial tear solutions.

Dec 07, 2020

To measure the rheological behaviour of artificial tears to gain insight into the potential role of rheology in predicting the efficacy of artificial tear solutions for the treatment of dry eye diseas...

Causes of blindness and vision impairment in 2020 and trends over 30 years, and prevalence of avoidable blindness in relation to VISION 2020: the Right to Sight: an analysis for the Global Burden of Disease Study.

Dec 07, 2020

Many causes of vision impairment can be prevented or treated. With an ageing global population, the demands for eye health services are increasing. We estimated the prevalence and relative contributio...

Glycated Hemoglobin and Blood Pressure Levels in Adults With Type 2 Diabetes: How Many Patients Are on Target?

Dec 07, 2020

Achieving glycated hemoglobin (A1C) and blood pressure targets is an important strategy for preventing chronic vascular complications in diabetes. Our aim in this study was to determine the proportion...

Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression.

Dec 07, 2020

Excitotoxicity is involved in the retinal neuronal cell death in diabetic retinopathy. Although fenofibrate has been shown to ameliorate the progression of diabetic retinopathy, the effect of pemafibr...

Endoscopic Vitreoretinal Surgery: Review of Current Applications and Future Trends.

Dec 07, 2020

Endoscopy provides unique optical properties to circumvent anterior segment opacities and visualize difficult-to-access anatomical regions, including retroirideal, retrolental, ciliary body and anteri...

Protection of ζ-crystallin by α-crystallin under thermal stress.

Dec 07, 2020

Cataract is one of the major causes of blindness worldwide. Several factors including post-translational modification, thermal and solar radiations promote cataractogenesis. The camel lens proteins su...

Cataract-causing mutations L45P and Y46D promote γC-crystallin aggregation by disturbing hydrogen bonds network in the second Greek key motif.

Dec 07, 2020

Congenital cataracts caused by genetic disorders are the primary cause of child blindness across the globe. In this work, we investigated the underlying molecular mechanism of two mutations, L45P and ...

Operative Time and Complication Rates of Resident Phacoemulsification Surgeries in a National University Hospital: A Five-Year Review.

Dec 07, 2020

To determine the operative time and complication rates of resident phacoemulsification surgeries at different time points in training.Retrospective cross-sectional study at the Department of Ophthalmo...

Safety and efficacy of mycophenolate mofetil in treating neuromyelitis optica spectrum disorders: a protocol for systematic review and meta-analysis.

Dec 03, 2020

Neuromyelitis optica spectrum disorders (NMOSD) is an inflammatory and heterogeneous astrocyte disorder of the central nervous system with the characteristic of higher incidence in women and Asian peo...

Natural history and clinical biomarkers of progression in X-linked retinitis pigmentosa: a systematic review.

Dec 03, 2020

X-linked retinitis pigmentosa (XLRP) accounts for a significant proportion of certifiable blindness in working-age adults. The objectives of this study were to: (1) synthesize the best available evide...

[Comparison of sterile donor tomography in the eye bank and graft tomography after penetrating keratoplasty].

Dec 03, 2020

Since 2018 we routinely use sterile donor tomography in the eye bank to avoid refractive surprises after keratoplasty. The purpose of this study was to compare donor tomography parameters measured wit...

Case Report: Use of Prosthetic Replacement of the Ocular Surface Ecosystem Treatment of Traumatic Lid Ptosis in a Pediatric Patient.

Dec 03, 2020

This report shares the long-term outcomes of an uncommon use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment and scleral lenses in the treatment for patients with ptosis wh...

Repeatability and reproducibility of manifest refraction.

Dec 03, 2020

To evaluate the intraexaminer repeatability and the interobserver reproducibility of manifest refraction.Tertiary referral center.Retrospective study.Patients attending at least 2 preoperative refract...