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Ophthalmology General

Defective INPP5E distribution in NPHP1-related Senior-Loken syndrome.

Dec 14, 2020

Senior-Loken syndrome is a rare genetic disorder that presents with nephronophthisis and retinal degeneration, leading to end-stage renal disease and progressive blindness. The most frequent cause of ...

Individualized Corneal Patching for Treatment of Corneal Trauma Combined with Tissue Defects.

Dec 14, 2020

To evaluate the efficacy of individualized corneal patching using a minimal graft for corneal trauma combined with tissue defects.Fifteen eyes (15 patients) were enrolled in this study, including 8 ey...

Hop flower extracts mitigate retinal ganglion cell degeneration in a glaucoma mouse model.

Dec 14, 2020

In glaucoma, retinal ganglion cells degenerate progressively, leading to visual field loss and blindness. Presently, the only treatment strategy for glaucoma is lowering the intraocular pressure. Howe...

Combined retinal proteome datasets in response to atropine treatment using iTRAQ and SWATH-MS based proteomics approaches in guinea pig myopia model.

Dec 14, 2020

Atropine, a non-selective muscarinic antagonist, is known to slow down myopia progression in human adolescents and in several animal models. However, its underlying molecular mechanism is unclear. The...

Ocular findings in metabolic syndrome: a review.

Dec 14, 2020

Metabolic syndrome (MetS) has emerged as a worldwide health hazard of the modern lifestyle, representing a cluster of metabolic abnormalities and a risk factor for cardiovascular disease. Eye diseases...

Effects of taking pregabalin (Lyrica) on the severity of dry eye, corneal sensitivity and pain after laser epithelial keratomileusis surgery.

Dec 14, 2020

Corneal nerve damage after laser epithelial keratomileusis (LASEK) is thought to be the cause of dry eye and pain. Therefore, we investigated whether taking pregabalin (Lyrica), which reduces peripher...

Abnormal Spontaneous Brain Activities of Limbic-Cortical Circuits in Patients With Dry Eye Disease.

Dec 14, 2020

Whether brain function is altered in patients with dry eye disease (DED) remains unclear. Twenty patients with DED and 23 healthy controls (HCs) were scanned using resting-state functional magnetic re...

Patient and provider perspectives on barriers to screening for diabetic retinopathy: an exploratory study from southern India.

Dec 14, 2020

Diabetic retinopathy is one of the leading causes of visual impairment after cataract and uncorrected refractive error. It has major public health implications globally, especially in countries such a...

Integrative Computational Approach Revealed Crucial Genes Associated With Different Stages of Diabetic Retinopathy.

Dec 14, 2020

The increased incidence of diabetic retinopathy (DR) and the legacy effect associated with it has raised a great concern toward the need to find early diagnostic and treatment strategies. Identifying ...

Quantitative assessment of choriocapillaris flow deficits in diabetic retinopathy: A swept-source optical coherence tomography angiography study.

Dec 14, 2020

To quantitatively assess choriocapillaris (CC) flow deficits in eyes with diabetic retinopathy (DR) using swept-source optical coherence tomography angiography (SS-OCTA).Diabetic subjects with differe...

Determinants of Optical Coherence tomography parameters in a population-based study.

Dec 14, 2020

To study the effects of age, gender, intraocular pressure, corneal thickness, axial length, disc area and the signal strength of the scan on optical coherence tomography (OCT) parameters of normal sub...

Atlas-based score for automatic glaucoma risk stratification.

Dec 14, 2020

Glaucoma is a disease that affects the optic nerve and can lead to blindness. The cup-to-disc ratio (CDR) measurement is one of the key clinical indicators for glaucoma assessment. However, the CDR on...

Artificial intelligence (AI) impacting diagnosis of glaucoma and understanding the regulatory aspects of AI-based software as medical device.

Dec 14, 2020

Glaucoma, the group of eye diseases is characterized by increased intraocular pressure, optic neuropathy and visual field defect patterns. Early and correct diagnosis of glaucoma can prevent irreversi...

Pars Plana Vitrectomy for Full-Thickness Macular Holes in Patients with Proliferative Diabetic Retinopathy and Active Fibrovascular Proliferation.

Dec 14, 2020

To study preoperative and postoperative optical coherence tomography features and the outcomes of pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for full-thickness macular h...

Meibography guided intraductal meibomian gland probing.

Dec 14, 2020

Researchers did this study to evaluate the use of infrared meibography video to visualize meibomian gland probing and correlate probe findings of intraductal space with meibography images. Researcher...

Severe dysfunctional tear syndrome patients and resolution of central corneal staining

Dec 14, 2020

Severe dry eye is widely prevalent yet challenging to treat. The researchers did this study to evaluate for improvement in epithelial status and the risk factors for lack of progress in a cohort of pa...

Prevalence and causes of vision loss in sub-Saharan Africa in 2015

Dec 14, 2020

Researchers did this study to assess the prevalence and causes of vision loss in SSA compared with prior years and estimate expected values. The present study is a systematic review and meta-analysis...

Vision loss in anterior uveitis

Dec 14, 2020

Researchers did this study to evaluate the long-term risk of permanent vision loss in subjects with anterior uveitis. The present study is a retrospective study of subjects attending the uveitis clin...

Tackling HTLV-1 infection in ophthalmology

Dec 14, 2020

Japan has been tackling HTLV-1 disorder and has made remarkable progress. In ophthalmology, awareness of the association between HTLV-1 and uveitis has been increasing since the 1990s. Here, we descri...

Central corneal basal cell density and nerve parameters

Dec 14, 2020

Researchers did this study to conduct a review and meta-analysis for investigating the relative reduction of central corneal BCD and nerve parameters in OSD and LSCD. Researchers carried out a system...