United States-based chemotherapy regimen for Ewing sarcoma is more effective and safer than the standard European regimen
1. The United States regimen had greater event-free survival and less associated febrile...
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Oncology
The experience of spirituality may positively impact the lives of terminal cancer patients
1. In this study, individuals were found to experience peace at the end of life through...
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Variation in prostate cancer screening rates associated with subsequent metastatic prostate cancer incidence
1. A retrospective analysis demonstrated that prostate-specific antigen (PSA) screening has...
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Continued enzalutamide after progression of metastatic prostate cancer improves progression-free survival
1. The median progression-free survival was higher in the enzalutamide vs the placebo group (9.5...
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Adjuvant pembrolizumab improved distant-metastasis free survival and lowered risk of recurrence in melanoma patients
1. In the pembrolizumab arm, distant metastasis-free survival was significantly improved and the...
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Polycystic ovarian syndrome is associated with an increased risk of pancreatic cancer
1. Polycystic ovarian syndrome (PCOS) diagnosis puts women at 1.9 times higher risk of pancreatic...
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Adding weightlifting exercises may further reduce risk of mortality
1. After adjusting for aerobic moderate to vigorous physical activity (MVPA), weightlifting was...
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Fine needle biopsy remains a reliable test for thyroid cancer diagnosis
1. In this systematic review and meta-analysis that included 16,597 patients, fine needle biopsy...
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Atezolizumab does not reduce post-resection recurrence in patients with renal cell carcinoma
1. Atezolizumab was associated with non-significantly increased disease-free survival compared to...
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Nivolumab plus ipilimumab improves recurrence-free survival in patients with resected advanced melanoma
1. 4-year recurrence-free survival was significantly higher with nivolumab plus ipilimumab...
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Optimized vitamin C levels may be associated with mitigated HPV infection risk
1. Though not statistically significant, there was a U-shaped found between vitamin C levels and...
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Stereotactic body radiation does not improve outcomes in patients with advanced Merkel cell carcinoma receiving nivolumab and ipilimumab
1. Objective response rate was not significantly different in patients treated with stereotactic...
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Ipilimumab addition to nivolumab showed no significant clinical benefit in resected advanced stage melanoma
Ipilimumab addition to nivolumab showed no significant clinical benefit in resected advanced stage...
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Letrozole and abemaciclib in estrogen receptor–positive recurrent endometrial cancer
1. Almost half of patients (47%) had either an objective response or had progression free survival...
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Fulvestrant for treatment of estrogen receptor-positive, HER2-negative advanced breast cancer may improve progression free survival using ESR1 mutation as guidance
1. Median progression free survival was longer in the fulvestrant and palbociclib group compared...
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Selpercatinib continues to demonstrate effective response in RET fusion-positive NSCLC
1. Selpercatinib was found to have similar effective objective response rates compared to past...
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Selpercatinib showed promising clinical activity in tumour-agnostic patients with RET fusion-positive cancers other than thyroid and lung cancer
1. Objective response rate was 43.9%. Patients treated with selpercatinib also experienced...
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More permissive parameters for active surveillance eligibility is potentially possible in slow-growing thyroid cancers
1. Patients in the active surveillance group who had forgone surgery had no difference in survival...
Read MoreIncreased pre-chemotherapy inflammatory biomarkers (IL-6 and CRP) correlated to increased risk of frailty post-chemotherapy in older breast cancer patients
1. 25.8% of patients receiving chemotherapy for breast cancer experienced worsening frailty status. 2. Patients with both biomarkers (IL-6 and CRP) elevated before chemotherapy had a significantly higher risk of decline in...
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Adjuvant pembrolizumab increased disease-free survival in completely resected, PD-L1 unselected non-small-cell lung cancer patients
1. Adjuvant pembrolizumab significantly improved disease-free survival in comparison to placebo in...
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