Nirogacestat, a γ-Secretase Inhibitor for Desmoid Tumors
1. There is a 71% lower risk of disease progression or death in the nirogacestat group than in the...
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Oncology
Sotorasib superior to docetaxel for treatment of KRASG12C-positive non-small-cell lung cancer
1. Patients allocated to the sotorasib group reported increased progression-free survival compared...
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Addition of PD-L1 inhibitor may improve outcomes in neoadjuvant therapy for esophageal cancer
1. In this phase II randomized clinical trial, treatment of patients with locally advanced...
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Combination therapy with alisterib and fulvestrant may be clinically advantageous in the treatment of endocrine-resistant advanced breast cancer
1. Compared to alisertib alone, adding alisertib to fulvestrant did not increase objective tumour...
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Maternity genitourinary tract infections associated with increased offspring leukemia risk in Danish cohort
1. In a Danish cohort, maternal genitourinary tract infection during pregnancy was associated with...
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Paid-sick-leave mandates contribute to increased cancer screening in the United States
1. Mandated and available paid-sick-leave resulted in increased colorectal and breast cancer...
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Neoadjuvant–Adjuvant vs. Adjuvant-Only Pembrolizumab in Advanced Melanoma
1. Event-free survival at 2 years was longer in the neoadjuvant-adjuvant group vs the...
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Liver enzymes elevated at 6 months prior to breast cancer liver metastasis detection
1. For patients diagnosed with breast cancer liver metastases (BCLM), liver function tests were...
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Low household income associated with worse outcomes for estrogen receptor-positive breast cancer
1. Low household income is associated with higher 21-gene recurrence scores (score based on gene...
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Risk model-based lung cancer screening is more cost effective than current practice
1. In this comparative modeling study, risk model-based lung cancer screening strategies yielded...
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Spirituality may improve coping in women diagnosed with breast cancer
1. In this scoping review, it was shown that spirituality allowed patients with breast cancer to...
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Medial retropharyngeal nodal region sparing radiotherapy for nasopharyngeal carcinoma
1. In this noninferiority trial, medial retropharyngeal lymph node (MRLN)-sparing radiotherapy was...
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Lobar vs Sublobar Resection for Peripheral Stage IA NSCLC
1. The 5-year disease-free survival, overall survival, and recurrence rates were similar in both...
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Anthracycline may be associated with increased incidence of heart failure
1. For patients with a history of lymphoma or breast cancer, anthracycline use is associated with...
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Momelotinib reduces symptom burden compared to danazol in patients with myelofibrosis
1. After a 24-week treatment period, a significantly greater proportion of patients randomized to...
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Faecal haemoglobin concentrations associated with mortality and cause of death in colorectal cancer screening
1. In this prospective cohort study, fecal hemoglobin concentration (f-Hb) was associated with...
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Adjuvant S-1 increases short-term survival in patients with resected biliary tract cancer
1. Patients who received adjuvant S-1 had prolonged overall survival and relapse-free survival...
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Plant-based diets may be associated with lower risk of aggressive prostate cancer
1. In this prospective cohort study, greater consumption of healthful plant-based foods was...
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Machine-learning based prompts for serious illness conversations reduces end of life systemic therapy use
1. The proportion of patients receiving serious illness conversations (SICs) was increased in the...
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Futibatinib for FGFR2 Mutated Intrahepatic Cholangiocarcinoma
1. Using futibatinib to treat patients with FGFR mutated intrahepatic cholangiocarcinoma resulted...
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