Mar 25, 2021

Forkhead box Q1 (FOXQ1) regulates epithelial ovarian cancer (EOC) cell proliferation, migration, and invasion, while its prognostic effect in EOC patients is unclear. This study aimed to assess FOXQ1...

Mar 18, 2021

The S2k guideline "Diagnostics and assessment of occupational asbestos-related diseases" was updated in November 2020. This article summarizes the most important changes. There is a new reference to t...

Mar 18, 2021

Therapeutic strategies for epithelial ovarian cancers are evolving with the advent of immunotherapy, such as PD-L1 inhibitors, with encouraging results. However, little data are available on PDL-1 exp...

Mar 18, 2021

There is a critical need to identify patient characteristics associated with long-term ovarian cancer survival.Quality of life (QOL), measured by the Functional Assessment of Cancer Therapy-Ovarian-Tr...

Feb 22, 2021

With long-term survivorship increasingly achievable among patients with cancer, many in this population face the outcomes of treatment-related late effects, explain Richard Anderson, MD, PhD, Matteo L...

Jan 18, 2021

Mutations in RAD51D are associated with a predisposition to primary ovarian, fallopian tube, and peritoneal carcinoma. Our study aims to characterize a RAD51D missense variant in a hereditary ovarian ...

Jan 18, 2021

Ovarian cancer is the third most common female cancer, with poor survival in later stages of metastatic spread. We test a chimeric virus consisting of genes from Lassa and vesicular stomatitis viruses...

Jan 14, 2021

Specialized breast cancer early detection programs with magnetic resonance imaging (MRI) in high-risk patients are by now well established in several countries. In Germany, such a program has been ru...

Jan 14, 2021

It has been long known that the oncogenic extracellular environment plays an indispensable role in developing and nurturing cancer cell progression and in resistance to standard treatments. However, b...

Jan 14, 2021

When powder is applied to the genital area, it has the potential to reach internal reproductive organs and promote carcinogenesis by irritating and inflaming exposed tissues. While many studies have c...

Jan 11, 2021

To validate the diagnostic performance of the Early-stage Ovarian Malignancy (EOM) score in an external dataset that includes advanced-stage and metastatic ovarian cancer.The data from two cross-secti...

Jan 11, 2021

Genes involved in the homologous recombination repair pathway-as exemplified by BRCA1, BRCA2, PALB2, ATM and CHEK2-are frequently associated with hereditary breast and ovarian cancer syndrome. Germlin...

Jan 07, 2021

Ovarian cancer (OC) is a highly malignant tumor. X inactive specific transcript (XIST) was identified as a cancer-related gene, while its therapeutic effect in OC was poorly defined. The present study...

Jan 07, 2021

RNF2 (also known as ding, Ring1B or Ring2) is a member of the Ring finger protein family, which functions as E3 ubiquitin ligase for monoubiquitination of histone H2A at lysine 119 (H2AK119ub). RNF2 g...

Jan 07, 2021

In this work, a nanocomposite of Zr-trimesic acid MOF (MOF-808) with carbon nanotube (CNT) was synthesized through an in situ formation of MOF-808 on the activated CNT. The synthesized materials were ...

Jan 04, 2021

15-Hydroxy-8(17),13(E)-labdadiene-19-carboxylic acid (HLCA) isolated from Juniperus foetidissima, has been recently identified as an antiproliferative agent; however, the molecular basis of antiprolif...

Jan 04, 2021

To evaluate the clinical significance and genomic associations of concurrent serous tubal intraepithelial carcinoma (STIC) with high-grade serous carcinoma (HGSC) of the ovary in women undergoing prim...

Jan 04, 2021

Surgical staging for apparent early stage ovarian cancer includes systematic pelvic and paraaortic lymph node evaluation to detect occult stage III disease. Though lymphadenectomy procedure is associa...

Dec 31, 2020

Targeted agents, such as antiangiogenic drugs (e.g., bevacizumab) and poly(ADP-ribose) polymerase inhibitors (e.g., rucaparib), have been shown to improve outcomes in patients with newly diagnosed or ...

Dec 31, 2020

Despite the use of front-line anticancer drugs such as paclitaxel for ovarian cancer treatment, mortality rates have remained almost unchanged for the past three decades and the majority of patients w...