Dec 31, 2020

Ovarian cancer (OvCa) is one of the leading causes of death due to its high metastasis rate to the peritoneum. Recurrent peritoneal tumors also develop despite the use of conventional platinum-based c...

Dec 24, 2020

Intraperitoneal chemotherapy (IPC) is a locoregional treatment option in patients with peritoneal metastases (PM). Here, we present an ovarian cancer (OC)-derived PM mouse model for the study of diffe...

Dec 24, 2020

Risk-reducing bilateral salpingo-oophorectomy (RRSO) is an effective strategy to prevent pelvic serous carcinoma for women at high risk of developing ovarian cancer; however, it results in premature m...

Dec 24, 2020

Ovarian cancer, as the malignant tumor with the highest mortality rate in gynecological tumors. At present, the main treatment for ovarian cancer is the combination of cytoreduction surgery and chemot...

Dec 21, 2020

Ovarian cancer is the most lethal gynaecological cancer, most patients relapse within 12 to 24 months, and eventually die, especially platinum-resistant patients. Gene therapy has been one of the most...

Dec 21, 2020

CRISPR-Cas9 system can be used to generate knock-out cancer cell lines. An insertion or deletion induced by a single guide RNA (gRNA) is often used to generate knock-out cells, however, some cells exp...

Dec 21, 2020

To overcome the drawbacks of conventional delivery, this review spotlights a number of nanoscale drug delivery systems, including nanoparticles, liposomes, nano micelles, branched dendrimers, nanocaps...

Dec 17, 2020

Platinum based chemotherapy is the treatment of choice for ovarian cancer patients with a platinum treatment free interval of >6 months. Niraparib is an oral poly (ADP-ribose) polymerase inhibitor ...

Dec 17, 2020

Sulfated glycosaminoglycans (GAGs) such as heparan sulfate (HS) are heteropolysaccharides implicated in the pathology of protein aggregation diseases including localized and systemic forms of amyloido...

Dec 17, 2020

AdCD40L is a replication-deficient virus carrying the gene for CD40 ligand which has previously been evaluated in patients with urothelial cancer and malignant melanoma. Herein, we present the results...

Dec 15, 2020

Published research has shown that women with ovarian cancer have among the highest rates of venous thromboembolisms (VTEs) of all patients with cancer. “An estimated 5% to 25% of patients with ovari...

Dec 14, 2020

Although cannabis remains illegal in many parts of the United States, 33 states have approved medical cannabis programs as of March 2020. “With the likely expansion of medical cannabis across the US...

Dec 14, 2020

Delivery of therapeutic small interfering RNA (siRNA) via functionalized nanoparticles holds great promise for cancer therapy. However, developing a safe and efficient delivery carrier of siRNA is a c...

Dec 14, 2020

B-cell CLL/lymphoma 7 protein family member C (BCL7C) located at chromosome 16p11.2 shares partial sequence homology with the other two family members, BCL7A and BCL7B. Its role in cancer remains comp...

Dec 14, 2020

The growth and spread of malignant tumors such as ovarian carcinomas are governed in part by complex interconnected-signaling cascades occurring between stromal and tumor cells. These reciprocal cross...

Dec 10, 2020

Although ovarian cancer is the leading cause of death from gynecological malignancies, there are still some issues that hamper accurate interpretation of the complexity of cellular and molecular event...

Dec 10, 2020

Despite high-grade serous ovarian cancer (HGSOC) being the most common and lethal gynecological cancer in women, the early etiological events driving disease development remain largely unknown. Emergi...

Dec 10, 2020

This study aimed to investigate the effects of multiwalled carbon nanotubes (MWCNTs) on cytotoxicity and tumor metastasis in ovarian cancer cells, and further explored its mechanism.MWCNTs significant...

Dec 07, 2020

The current study was undertaken to examine the anticancer potential of davanone against human ovarian cancer cells along with evaluating its effects on cell apoptosis, PI3K/AKT/MAPK signaling pathway...

Dec 07, 2020

The medical and surgical treatment strategies for women with epithelial ovarian cancer continue to evolve. In the past several years, there has been significant progress backed by landmark clinical tr...