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Menopause

The Impact of Skeletal Muscle ERα on Mitochondrial Function and Metabolic Health.

Feb 18, 2020

The incidence of chronic disease is elevated in women after menopause. Increased expression of ESR1 (the gene that encodes the estrogen receptor alpha, ERα) in muscle is highly associated with metabo...

Maternal and Infant Anthropometric Characteristics and Breast Cancer Incidence in the Daughter.

Feb 18, 2020

The intrauterine and early life environments have been linked to the etiology of breast cancer in prior studies. We prospectively examined whether maternal and newborn anthropometric factors as report...

Impact of sex on response to neoadjuvant chemotherapy in patients with bladder cancer.

Feb 18, 2020

To assess the effect of patient's sex on response to neoadjuvant chemotherapy (NAC) in patients with clinically nonmetastatic muscle-invasive bladder cancer (MIBC).Complete pathologic response, define...

Postmenopausal hormone therapy and Alzheimer's disease, dementia, and Parkinson's disease: A systematic review and time-response meta-analysis.

Feb 18, 2020

Hormone therapy continues to be a favourable option in the management of menopausal symptomatology, but the associated risk-benefit ratios with respect to neurodegenerative diseases remain controversi...

Transitions in metabolic and immune systems from pre-menopause to post-menopause: implications for age-associated neurodegenerative diseases.

Feb 13, 2020

The brain undergoes two aging programs: chronological and endocrinological. This is particularly evident in the female brain, which undergoes programs of aging associated with reproductive competency....

The role of physical activity in the link between menopausal status and mental well-being.

Feb 13, 2020

To examine the relationship between menopausal status and mental well-being, and whether this relationship varies as a function of physical activity (PA).Based on a hormonal analysis and bleeding diar...

Association of hot flushes with ghrelin and adipokines in early versus late postmenopausal women.

Feb 13, 2020

Vasomotor flushing (hot flushes) is a common menopausal symptom experienced by most women going through the menopausal transition; flushing continues for a variable period in postmenopause. Primarily ...

Gabapentin for the treatment of hot flushes in menopause: a meta-analysis.

Feb 13, 2020

Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gab...

Optical Vaginal Biopsy Using Optical Coherence Tomography.

Jan 30, 2020

Optical coherence tomography is a noninvasive technology that visualizes tissue microstructure with high spatial resolution. We designed a novel vaginal system that demonstrates a clear distinction be...

Levonorgestrel-releasing intrauterine system and breast cancer risk: A systematic review and meta-analysis.

Jan 30, 2020

Epidemiological studies have shown that some hormonal contraceptive methods are associated with increased breast cancer risk, especially if used over long periods. Our objective was to conduct a syste...

Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review.

Jan 30, 2020

Recurrent vulvovaginal infections (RVVI) has not only become an epidemiological and clinical problem but also include large social and psychological consequences. Understanding the mechanisms of both ...

Female Heart Health: Is GPER the Missing Link?

Jan 30, 2020

The G Protein-Coupled Estrogen Receptor (GPER) is a novel membrane-bound receptor that mediates non-genomic actions of the primary female sex hormone 17β-estradiol. Studies over the past two decades ...

Relationship between osteogenesis and angiogenesis in ovariectomized osteoporotic rats after exercise training.

Jan 24, 2020

To reveal the role of exercise training in regulating osteogenesis and angiogenesis in rats after ovariectomy (OVX), then further examine the relationship between osteoporosis (OP) and local blood sup...

p75NTR promotes survival of breast cancer resistant cells by regulating Bcl-2/Bax and MAPK pathway.

Jan 24, 2020

In breast cancer, the neurotrophin receptor p75NTR is a critical factor that promotes resistance to the drug, however, its mechanism of action remains unclear. In our study, the 10 cases of positive e...

Night Shift Work-A Risk Factor for Breast Cancer.

Jan 24, 2020

Shift work is considered a risk factor for some health problems. This study aimed to determine whether night shift work is a significant factor for breast cancer risk. The case-control study was condu...

Arterial Stiffness Accelerates Within 1 Year of the Final Menstrual Period: The SWAN Heart Study.

Jan 24, 2020

Menopause may augment age-dependent increases in arterial stiffness, with black women having greater progression in midlife compared with white women. We sought to determine whether and when women exp...

The Effects of Carob ( L.) on Emotional Behavior Impairment and Metabolic Disorders Induced by Estrogen Deficiency in Rats.

Jan 24, 2020

Carob ( L.) contains a wide variety of polyphenols with high antioxidant properties. In this study, we investigated the effects of aqueous extract of carob pods (AECP) on emotional behavior impairment...

Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency.

Jan 23, 2020

BMP15 encodes an oocyte factor with a relevant role for folliculogenesis as homodimer or cumulin heterodimer (BMP15-GDF9). Heterozygous BMP15 variants in the precursor or mature peptide had been assoc...

The impact of hormones and reproductive factors on the risk of bladder cancer in women: results from the Nurses' Health Study and Nurses' Health Study II.

Jan 23, 2020

With three out of four new bladder cancer (BCa) cases occurring in men, an apparent gender disparity exists. We aimed to investigate the role of hormonal and reproductive factors in BCa risk using two...

Anti-Mullerian Hormone and Impending Menopause in Late Reproductive Age: The Study of Women's Health Across the Nation.

Jan 23, 2020

A test that helps predict the time to the final menstrual period (FMP) has been sought for many years.To assess the ability of Anti-Mullerian Hormone (AMH) measurements to predictions the time to FMP....

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