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OB/GYN General

Developmental loss, but not pharmacological suppression, of renal carbonic anhydrase 2 results in pyelonephritis susceptibility.

May 12, 2020

Carbonic anhydrase II (CA-II) knockout mice (Car2)have depleted numbers of renal intercalated cells which are increasingly recognized to be innate immune effectors. We compared pyelonephritis suscepti...

A Multifaceted Antimicrobial Stewardship Program for the Treatment of Uncomplicated Cystitis in Nursing Home Residents.

May 12, 2020

Urinary tract infections are the most common infections in nursing home residents. However, most antibiotic use is for unlikely cystitis (ie, nonspecific symptoms and positive culture results secondar...

Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.

May 12, 2020

Herpesviruses acquire their membrane envelopes in the cytoplasm of infected cells via a molecular mechanism that remains unclear. Herpes simplex virus (HSV)-1 proteins pUL7 and pUL51 form a complex re...

Hepatitis C Virus Infection and Treatment as Independent Prognostic Factors in Diffuse Large B-Cell Lymphoma Egyptian Patients.

May 12, 2020

Egypt is one of highest hepatitis C virus (HCV) endemic areas. Chronic HCV infection has extra-hepatic manifestations, including non-Hodgkin lymphoma (NHL). Diffuse large B-cell lymphoma (DLBCL) is co...

Hepatitis C Screening Rates and Care Cascade in a Large US Insured Population, 2010-2016: Gaps to Elimination.

May 12, 2020

Understanding the health care system's ability to move patients through the hepatitis C virus (HCV) care cascade from screening to treatment is essential for HCV elimination. This retrospective study ...

Population-based study of autoimmune hepatitis and primary biliary cholangitis in Germany: rising prevalences based on ICD codes, yet deficits in medical treatment.

May 12, 2020

 Population-based data on the prevalence of and real-life treatment for the autoimmune liver diseases (AILD), primary biliary cholangitis (PBC) and autoimmune hepatitis (AIH), are scarce, and such k...

Successful fourth line treatment of a relapse patient with chronic hepatitis C virus infection genotype 3a using sofosbuvir, glecaprevir/pibrentasvir, and ribavirin: a case report.

May 12, 2020

 Relapses after therapy with direct-acting antiviral agents (DAA) in chronic hepatitis C virus (HCV) infections are rare due to high efficacy of interferon-free therapy regimens. The presence of res...

[Evaluation of Sysmex UF-1000i® flow cytometer as a screening method for asymptomatic bacteriuria and detection of Group B Streptococcus in pregnancy].

May 12, 2020

Nowadays, the use of flow-cytometry for the screening of urine samples is extended, but appropriate cut-off points for each population group are yet to be established. The objective of this study was ...

Comparative Study of the Clinical Application of 2 Bleeding Grading Systems for Pregnant Women With Immune Thrombocytopenia.

May 12, 2020

To compare the clinical practicability of two bleeding grading systems (BGS) in pregnancy with Immune Thrombocytopenia (ITP). The clinical data of 154 cases were retrospectively analyzed with the 20...

Preventive effects of folic acid on Zika virus-associated poor pregnancy outcomes in immunocompromised mice.

May 12, 2020

Zika virus (ZIKV) infection may lead to congenital microcephaly and pregnancy loss in pregnant women. In the context of pregnancy, folic acid (FA) supplementation may reduce the risk of abnormal pregn...

Second trimester cervical length measurements with transvaginal ultrasound: a prospective observational agreement and reliability study.

May 12, 2020

Universal screening for preterm delivery by adding transvaginal ultrasound measurement of cervical length to routine second trimester ultrasound has been proposed. The aim is to estimate inter- and in...

Effect of the COVID-19 pandemic on female sexual behavior.

May 12, 2020

To evaluate the effect of the COVID-19 pandemic on female sexual behavior in women in Turkey.An observational study using data from a previous study conducted prior to the pandemic. We compared freque...

Prognostic significance of elevated pretreatment serum levels of CEA and CA-125 in epithelial ovarian cancer.

May 12, 2020

Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatmen...

Heterogeneity of immune microenvironment in ovarian cancer and its clinical significance: a retrospective study.

May 12, 2020

Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates in OC beca...

Gold(iii) bis(dithiolene) complexes: from molecular conductors to prospective anticancer, antimicrobial and antiplasmodial agents.

May 12, 2020

The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes 1-6 showed relevant anticancer properties against A2780/A2780cisR ovarian...

Combined CCNE1 high-level amplification and overexpression is associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma.

May 12, 2020

CCNE1 amplification is a recurrent alteration associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma (HGSC). We aimed to investigate whether immunohistochemistry (IHC) can be...

Strategic combination therapies for ovarian cancer.

May 12, 2020

Ovarian cancer remains the leading cause of gynecologic cancer-related death among women worldwide. The dismal survival rate is partially due to recurrence after standardized debulking surgery and fir...

Use of a shaving technique for surgical management of partial ureteral obstruction due to endometriosis.

May 12, 2020

To illustrate the surgical management of advanced endometriosis causing extrinsic ureteral compression.Video description of the case, demonstration of the surgical technique, reevaluation at 14-year f...

Can environmental pollutant bisphenol A increase metabolic risk in polycystic ovary syndrome?

May 12, 2020

Bisphenol A (BPA), a widespread industrial substance is recognized as endocrine disrupting chemical and therefore could be associated with polycystic ovary syndrome (PCOS) related metabolic disturbanc...

Pathophysiological implications of hypoxia in human diseases.

May 12, 2020

Oxygen is essentially required by most eukaryotic organisms as a scavenger to remove harmful electron and hydrogen ions or as a critical substrate to ensure the proper execution of enzymatic reactions...

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