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OB/GYN General

Genistein loaded in self-assembled bovine serum albumin nanovehicles and their effects on mouse mammary adenocarcinoma cells.

May 03, 2021

Antitumor activity of plant-derived flavonoids has been researched during recent decades. Among them, genistein (Gen) stands out for showing cytotoxic activity against breast cancer cells. However, it...

Carbon fiber-reinforced PEEK instrumentation in the spinal oncology population: a retrospective series demonstrating technique, feasibility, and clinical outcomes.

May 03, 2021

The authors aimed to demonstrate the feasibility and advantages of carbon fiber-reinforced PEEK (CFRP) composite implants in patients with both primary and secondary osseous spinal tumors.Twenty-eight...

A survey of Japanese interns to prepare for mandatory clinical training in obstetrics and gynecology.

May 03, 2021

Obstetrics and gynecology (Ob/Gyn) training became compulsory for Japanese physician interns from April 2020 to improve medical competence in treating women's diseases. This study aims to understand t...

In the Name of Prevention: Maternal Perspectives on School-Based HPV Vaccination in Rural Southern Chile.

May 03, 2021

Since the introduction of the HPV vaccine in Chile in 2014, there have been few studies exploring community perspectives on the vaccine, specifically of parents of adolescents. This study sought to id...

The Duration of Antibiotics Prophylaxis at the Time of Catheter Removal after Radical Prostatectomy: Clinically-Integrated, Cluster, Randomized Trial.

Apr 29, 2021

Prophylactic antibiotics are routinely given at the time of catheter removal post radical prostatectomy (RP). The low rate of infectious complications entails that large sample sizes are required for ...

Placentas associated with female neonates from pregnancies complicated by urinary-tract infections have higher cAMP content and cytokines expression than males.

Apr 29, 2021

The cAMP pathway is involved in important biological processes including immune regulation and hormone signaling. At the feto-maternal unit, cAMP participates in placental function/physiology and the ...

Screening for idiopathic normal pressure hydrocephalus in the elderly after falls.

Apr 29, 2021

Many patients with idiopathic normal pressure hydrocephalus (iNPH) have reportedly fallen prior to diagnosis. However, there are no previous reports on the iNPH prevalence among the elderly with histo...

Reproductive Health Care for Incarcerated Pregnant, Postpartum, and Nonpregnant Individuals.

Apr 29, 2021

Obstetrician-gynecologists and other women's health care practitioners can support efforts to improve health care for incarcerated pregnant, postpartum, and nonpregnant individuals. The majority of in...

PAX8 and MECOM are interaction partners driving ovarian cancer.

Apr 29, 2021

The transcription factor PAX8 is critical for the development of the thyroid and urogenital system. Comprehensive genomic screens furthermore indicate an additional oncogenic role for PAX8 in renal an...

IGF-1R anti-idiotypic antibody antagonist exhibited anti-ovarian cancer bioactivity and reduced cisplatin resistance.

Apr 29, 2021

Ovarian cancer is the most deadly gynecological malignant tumor in the world today. Previous studies have shown that insulin-like growth factor-1 receptor (IGF-1R) is closely related to the occurrence...

Development of a high payload, cancer-targeting liposomes of methyl aminolevulinate for intraoperative photodynamic diagnosis/therapy of peritoneal carcinomatosis.

Apr 29, 2021

Methyl aminolevulinate (MAL) is a photosensitizer topically used for photodynamic diagnosis (PDD) and photodynamic therapy (PDT) of skin pre-cancers and cancers. In this study, our goal is to expand t...

A High-Androgen Microenvironment Inhibits Granulosa Cell Proliferation and Alters Cell Identity.

Apr 29, 2021

A naturally occurring bovine model with excess follicular fluid androstenedione (High A4), reduced fertility, and polycystic ovary syndrome (PCOS)-like characteristics has been identified. We hypothes...

Prediction of severe neutropenia and diarrhoea in breast cancer patients treated with abemaciclib.

Apr 29, 2021

Neutropenia and diarrhoea are common and potentially serious adverse events associated with abemaciclib in advanced breast cancer (ABC), and the risk factors have been minimally explored. The study ai...

Preparation, characterization, and in vitro tumor-suppressive effect of anti-miR-21-equipped RNA nanoparticles.

Apr 29, 2021

MicroRNAs play an irreplaceable role in gene expression regulation. Upregulation of several miRNAs increases the risk of invasion and metastasis of breast cancer cells. An oncogenic miRNA, miR-21, is ...

Effect of an educational intervention on women's healthcare provider knowledge gaps about breast density, breast cancer risk, and screening.

Apr 29, 2021

We sought to assess the effect of an educational intervention, based on DenseBreast-info.org website content, on women's healthcare provider knowledge of breast density, its risk and screening implica...

Failure to Rescue Drives Racial Disparity in Maternal Mortality

Apr 28, 2021

WEDNESDAY, April 28, 2021 (HealthDay News) -- Failure to rescue from severe maternal morbidity contributes to more than half of the threefold difference in maternal mortality between Black women and W...

Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli.

Apr 26, 2021

Kidney intercalated cells are involved in acid-base homeostasis via vacuolar ATPase expression. Here we report six human intercalated cell subtypes, including hybrid principal-intercalated cells ident...

Tamsulosin Versus Placebo to Prevent Postoperative Urinary Retention Following Female Pelvic Reconstructive Surgery: a Multicenter Randomized Controlled Trial.

Apr 26, 2021

Postoperative urinary retention is common following female pelvic reconstructive surgery. Alpha receptor antagonists can improve dysfunctional voiding by relaxing the bladder outlet, and may be effect...

Preconceptional and the first trimester exposure to PM and offspring neurodevelopment at 24 months of age: Examining mediation by maternal thyroid hormones in a birth cohort study.

Apr 26, 2021

Prenatal fine particulate matter (PM) exposure has been associated with impaired offspring neurodevelopment; however, the association of PM exposure during preconception with offspring's neurodevelopm...

A Population Pharmacokinetic Meta-analysis of Veliparib, a PARP Inhibitor, Across Phase I/II/III Trials in Cancer Patients.

Apr 26, 2021

Veliparib (ABT-888) is a poly (ADP-ribose) polymerase (PARP) inhibitor in development for treatment of high-grade ovarian cancer or BRCA-mutated breast cancer in combination with carboplatin and pacli...

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