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OB/GYN General

Levetiracetam exposure during prenatal and postnatal period induces cognitive decline in rat offsprings, not completely prevented by .

Jul 22, 2021

Levetiracetam (LEV) is an antiepileptic recommended during pregnancy. is a medicinal herb used in Ayurveda for improvement of cognition. Data on effects of LEV and Bacopa on cognition is inadequate. ...

Gadolinium-labeled affibody-XTEN recombinant vector for detection of HER2+ lesions of ovarian cancer lung metastasis using quantitative MRI.

Jul 22, 2021

Ovarian cancer has the highest mortality rate among all gynecologic malignancies. HER2 ovarian cancer is a subtype that is aggressive and associated with metastasis to distant sites such as the lungs....

Potential of thrombospondin-1 in treatment of polycystic ovary syndrome rat model: a preliminary study.

Jul 22, 2021

Polycystic ovary syndrome (PCOS) is a common gynecological endocrine disease in reproductive women, and the endocrine levels are also affected by diseases. The aim of this study was to determine the e...

CYP2D6 Genotype Predicts Tamoxifen Discontinuation and Drug Response: A Secondary Analyses of the KARISMA Trial.

Jul 22, 2021

Guidelines are conflicting and have caused confusion regarding whether tamoxifen should be prescribed based on women's CYP2D6 genotypes. This study aims to investigate if CYP2D6 metabolizer status is ...

OncotypeDX© Recurrence Score in BRCA mutation carriers: a systematic review and meta-analysis.

Jul 22, 2021

There are limited data comparing the OncotypeDX© Recurrence Score (RS) among BRCA mutation carriers and patients with sporadic breast cancer.To compare RS results among BRCA mutation carriers and pat...

A radiation ulcer that required partial lung resection and recurred in a small residual area of ectopic calcification.

Jul 22, 2021

Surgery for chest radiation ulcers must involve appropriate wide margins, but it is not usually possible to remove all radiation-damaged tissue. Therefore, it is difficult to determine how extensive s...

Implementation and Assessment of a Novel Telehealth Education Curriculum for Undergraduate Medical Students.

Jul 22, 2021

Despite its healthcare advantages and expanded use during the COVID-19 pandemic, telehealth is not included in many medical school curricula.In this prospective mixed methods study (n=52), we created ...

Knowledge and attitude about intrauterine contraceptive devices among patients attending the National Guard Hospital in Jeddah, Saudi Arabia: a cross-sectional study.

Jul 22, 2021

To investigate women's knowledge and attitudes regarding the use of the intrauterine device (IUD) for contraceptive purposes and to explore eventual misconceptions about its benefits, and disadvantage...

Novel urine biomarkers to distinguish UTI from culture-negative pyuria.

Jul 19, 2021

Emergency departments (EDs) often rely on urinalysis (UA) to rapidly identify urinary tract infections (UTIs) in children. However, the suboptimal test characteristics of UA can lead to false-positive...

URINARY CATHETER ALLEVIATION NAVIGATOR PROTOCOL (UCANP): OVERVIEW OF PROTOCOL AND REVIEW OF INITIAL EXPERIENCE.

Jul 19, 2021

Given the associated morbidity, mortality, and financial consequences of catheter associated urinary tract infections (CAUTIs), efforts should be made to mitigate the risk. We sought to describe, and ...

Hemolytic activity and biofilm-formation among clinical isolates of group B streptococcus causing acute urinary tract infection and asymptomatic bacteriuria.

Jul 19, 2021

Streptococcus agalactiae, also known as group B Streptococcus, is an aetiological agent of urinary tract infection (UTI) in adults, including cystitis, pyelonephritis and asymptomatic bacteriuria (ABU...

Human biomonitoring of essential, nonessential, rare earth, and noble elements in placental tissues.

Jul 19, 2021

Exposure to certain metals has been recognized as a risk factor for numerous complications in vulnerable population groups, particularly pregnant women. This investigation evaluated the levels of esse...

The metabolic landscape of decidua in recurrent pregnancy loss using a global metabolomics approach.

Jul 19, 2021

Maternal metabolism undergoes dynamic changes during pregnancy. A deviation from this physiological metabolic status might be involved in the pathogenesis of pregnancy complications, such as recurrent...

ARID1A mutation/ARID1A loss is associated with a high immunogenic profile in clear cell ovarian cancer.

Jul 19, 2021

ARID1A mutation is frequently found in clear cell ovarian cancer (CCC) and endometrioid ovarian cancer (EC). Anti-PD-1 monotherapy has been found to have limited efficacy in epithelial ovarian cancer;...

Prognostic significance of high circulating sHLA-G in ovarian carcinoma.

Jul 19, 2021

Human leukocyte antigen (HLA)-G is a non-classical major histocompatibility complex class Ib molecule. Its expression has been described in various cancer types, including ovarian cancer. HLA-G molecu...

Involvement of ATMIN-DYNLL1-MRN axis in the progression and aggressiveness of serous ovarian cancer.

Jul 19, 2021

The loss of DYNLL1 contributes to chemoresistance in ovarian cancer. DYNLL1 binds to MRE11, a component of MRN complex (MRE11-RAD50-NBS1), and limits its function in homologous recombination (HR) repa...

Association of decreased sperm motility and increased seminal plasma IGF-I, IGF-II, IGFBP-2, and PSA levels in infertile men.

Jul 19, 2021

Previous studies have suggested the involvement of serum insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the regulation of the female reproductive system. Little is known of th...

Real world data on adjuvant treatment of older HER2-positive breast cancer patients - A single institution experience through 8 years.

Jul 19, 2021

The large randomized trials on trastuzumab for primary breast cancer (BC) included few old patients. With exception of endocrine treatment, trials on adjuvant therapy for the old group specifically ar...

Cost-Effectiveness of Population Level and Individual Level Interventions to Combat Non-communicable Disease in Eastern Sub-Saharan Africa and South East Asia: A WHO-CHOICE Analysis.

Jul 19, 2021

To determine the health system costs and health-related benefits of interventions for the prevention and control of non-communicable diseases (NCDs), including mental health disorders, for the purpose...

Assessment of the Benefits and Cost-Effectiveness of Population-Based Breast Cancer Screening in Urban China: A Model-Based Analysis.

Jul 19, 2021

To decrease the burden of breast cancer (BC), the Chinese government recently introduced biennial mammography screening for women aged 45-70 years. In this study, we assess the effectiveness and cost-...

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