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OB/GYN General

Clinical factors associated with a placenta accreta spectrum.

Aug 12, 2021

Placenta accreta spectrum (PAS) is a life-threating obstetric complication, and prenatal prediction of PAS can decrease maternal morbidity and mortality. The aim of this prospective cohort study was t...

A new pipeline for clinico-pathological and molecular placental research utilizing FFPE tissues.

Aug 12, 2021

The placenta is at the core of many pregnancy pathologies, but we have limited knowledge about placental function because of two key research barriers: 1) lack of guidelines for sample collection and ...

Preeclampsia and cancer risk in women in later life: a systematic review and meta-analysis of cohort studies.

Aug 12, 2021

Results of this work may provide some guidance for subsequent ovarian cancer screening in women with preeclampsia and provide new directions for future studies.This study investigated the difference i...

Dysfunctional activity of classical DNA end-joining renders acquired resistance to carboplatin in human ovarian cancer cells.

Aug 12, 2021

Ovarian cancer is the deadliest gynecological malignancy worldwide. Although chemotherapy is required as the most standard treatment strategy for ovarian cancer, the survival rates are very low, large...

Sexual dysfunction in Thai gynecologic malignancies survivors: A single-institutional cross-sectional observational survey.

Aug 12, 2021

To examine the prevalence of female sexual dysfunction (FSD) in gynecologic cancer survivors.A cross-sectional observation survey recruited women aged 18-65 years old who were diagnosed with gynecol...

Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats.

Aug 12, 2021

The purpose of this study was to explore the effect of dulaglutide on DHEA induced PCOS rats and its mechanism, to provide new drugs and research directions for clinical treatment of PCOS.In this stud...

ATXN7L3B promotes hepatocellular carcinoma stemness and is downregulated by metformin.

Aug 12, 2021

Hepatocellular carcinoma (HCC) is the major cause of liver cancer-associated morality. Metformin, used for treating type 2 diabetes, has antitumor activity and reduces the risk of some diabetes-relate...

Studying the pathological and biochemical features in breast cancer progression by confocal Raman microspectral imaging of excised tissue samples.

Aug 12, 2021

Confocal Raman microspectral imaging (CRMI) has been used to detect the spectra-pathological features of ductal carcinoma in situ (DCIS) and lobular hyperplasia (LH) compared with the heathy (H) breas...

Prolactin enhances T regulatory cell promotion of breast cancer through the long form prolactin receptor.

Aug 12, 2021

Previous work has shown systemic knockdown of the long form prolactin receptor (LFPRLR) in vivo markedly reduced metastasis in mouse models of breast cancer, but whether this translated to prolonged s...

Short term catheter management options for urinary retention following pelvic surgery: a cost analysis.

Aug 09, 2021

Several studies have compared short term catheterization approaches and have demonstrated no difference in patient satisfaction, but none have evaluated their costs.To evaluate the costs of three path...

Which symptoms of pelvic floor dysfunction does physiotherapy improve after an OASI?

Aug 09, 2021

Obstetric Anal Sphincter Injury (OASI) is associated with significant morbidity in the form of pelvic floor dysfunction, both in the immediate period of healing and long term. The aim of this study wa...

Sarcopenia is associated with incontinence and recovery of independence in urination and defecation in post-acute rehabilitation patients.

Aug 09, 2021

The aim of this study was to examine the association between sarcopenia and recovery of independence in urination and defecation in patients undergoing convalescent rehabilitation.This single-center, ...

Intimate partner violence and the association of pregnancy intendedness - A cross-sectional study in southeastern Norway.

Aug 09, 2021

Unintended pregnancy in the context of intimate partner violence (IPV) is a public health issue. It is associated with increased health risks for women and their children. Our objective was to investi...

How women and providers perceive male partner resistance to contraceptives in Western Kenya: A qualitative study.

Aug 09, 2021

Almost a fifth of Kenyan women who desire to delay or avoid pregnancy are not using modern contraception. The objective of this study is to describe how Kenyan women, healthcare providers, and health ...

An In-Depth Review of Niraparib in Ovarian Cancer: Mechanism of Action, Clinical Efficacy and Future Directions.

Aug 09, 2021

Niraparib is an oral, potent, highly selective poly-ADP ribose polymerase 1 (PARP1) and PARP2 inhibitor. In most developed countries, it is approved as a maintenance treatment for epithelial ovarian,...

Loss of KLF9 facilitates stemness in ovarian cancer ascites-derived multicellular spheroids via Notch1/Slug signaling.

Aug 09, 2021

The ascites that develops in advanced ovarian cancer (OC), both at diagnosis and upon recurrence, is a rich source of multi-cellular spheroids/aggregates (MCSs/MCAs), which are the major seeds of tumo...

Chemotherapy with or without avelumab followed by avelumab maintenance versus chemotherapy alone in patients with previously untreated epithelial ovarian cancer (JAVELIN Ovarian 100): an open-label, randomised, phase 3 trial.

Aug 09, 2021

Although most patients with epithelial ovarian cancer respond to frontline platinum-based chemotherapy, around 70% will relapse within 3 years. The phase 3 JAVELIN Ovarian 100 trial compared avelumab ...

Association of body mass index with serum anti-Müllerian hormone and inhibin B levels among 8323 women attending a reproductive medical center: a cross-sectional study.

Aug 09, 2021

To assess the association of body mass index (BMI) with serum anti-Müllerian hormone (AMH) and inhibin B (InB) levels among women attending a reproductive medical center.We conducted a cross-sectiona...

Macrophage-mediated multi-mode drug release system for photothermal combined with anti-inflammatory therapy against postoperative recurrence of triple negative breast cancer.

Aug 09, 2021

Surgery combined with postoperative treatment is a widely accepted therapeutic strategy against breast cancer. Macrophage-based carriers have been proved to be an effective postoperative drug delivery...

Balanced dual acting compounds targeting aromatase and estrogen receptor α as an emerging therapeutic opportunity to counteract estrogen responsive breast cancer.

Aug 09, 2021

Breast Cancer (BC) is a leading cause of death in women, currently affecting 13% of female population worldwide. First-line clinical treatments against Estrogen Receptor positive (ER+) BC rely on supp...

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