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OB/GYN General

Obstetrician–Gynecologists' Practices in Postpartum Sterilization

Nov 02, 2021

To investigate obstetrician–gynecologists' practises in the United States regarding postpartum sterilisation where the Medicaid permission form was not legitimate was the study’s goal. Using the A...

Two-Layer Compared With One-Layer Vaginal Cuff Closure

Nov 02, 2021

The purpose of this study is to see if two-layer laparoscopic vaginal cuff closure during laparoscopic hysterectomy is linked with a reduced risk of postoperative problems than a normal one-layer cuff...

Cognitive-behavioral therapy and urge urinary incontinence in women. A systematic review.

Nov 01, 2021

UUI co-exists with numerous health conditions, having a substantial negative impact on health-related quality of life and mental health. Cognitive-behavioral therapy (CBT) could help patients manage t...

Neurovascular structure-adjacent frozen-section examination robotic-assisted radical prostatectomy: outcomes from 500 consecutive cases in the UK.

Nov 01, 2021

The purpose is to report the United Kingdom's largest single-centre experience of robotically assisted laparoscopic radical prostatectomies (RALP), using the neurovascular structure-adjacent frozen-se...

1-Nitropyrene exposure impairs embryo implantation through disrupting endometrial receptivity genes expression and producing excessive ROS.

Nov 01, 2021

Haze problem is an important factor threatening human health. PM2.5 is the main culprit haze. 1-Nitropyrene (1-NP) is the main nitrated polycyclic aromatic hydrocarbon, the toxic component of PM2.5 pa...

Efficacy and safety of standard of care with/without bevacizumab for platinum-resistant ovarian/fallopian tube/peritoneal cancer previously treated with bevacizumab: the Japanese Gynecologic Oncology Group study JGOG3023.

Nov 01, 2021

We investigated the efficacy and safety of further bevacizumab therapy in platinum-resistant ovarian cancer patients whose disease had progressed after bevacizumab plus chemotherapy. In this multi-cen...

DOG1 expression is common in human tumors: A tissue microarray study on more than 15,000 tissue samples.

Nov 01, 2021

DOG1 (Discovered on GIST1) is a voltage-gated calcium-activated chloride and bicarbonate channel that is highly expressed in interstitial cells of Cajal and in gastrointestinal stromal tumors (GIST) d...

Copy number variants within AZF region of Y chromosome and their association with idiopathic male infertility in Serbian population.

Nov 01, 2021

Results of numerous studies gave contradictory conclusions when analysing associations between copy number variants (CNVs) within the azoospermia factor (AZF) locus of the Y chromosome and idiopathic ...

Design, synthesis and binding mode of interaction of novel small molecule o-hydroxy benzamides as HDAC3-selective inhibitors with promising antitumor effects in 4T1-Luc breast cancer xenograft model.

Nov 01, 2021

Histone deacetylase 3 (HDAC3) is one of the most promising targets to develop anticancer therapeutics. In continuation of our quest for selective HDAC3 inhibitors, a series of small molecules having o...

CCR5 is a prognostic biomarker and an immune regulator for triple negative breast cancer.

Nov 01, 2021

This study aims to explore the clinical implications and potential mechanistic functions of CCR5 in triple negative breast cancer. Briefly, we demonstrated that CCR5 is overexpressed in TNBC and is as...

Racial/Ethnic Disparity Found in Severe Maternal Morbidity

Oct 25, 2021

Racial and ethnic disparities in maternal health outcomes are pronounced and persistent in the United States, and—to some extent—remain unexplained, according to Alecia J. McGregor, PhD. “In par...

Population Pharmacokinetic Modeling and Probability of Pharmacodynamic Target Attainment for Ceftazidime-Avibactam in Pediatric Patients Aged 3 Months and Older.

Oct 25, 2021

Increasing prevalence of infections caused by antimicrobial-resistant Gram-negative bacteria represents a global health crisis, and while several novel therapies that target various aspects of antimic...

Evaluation of the long-term effect and complication rate of single-incision slings for female stress urinary incontinence.

Oct 25, 2021

To evaluate the long-term outcomes of single-incision midurethral slings (SIMS) in real-life practice.This retrospective, single-arm, patient cohort study was performed in a large Dutch teaching hospi...

Plane of nutrition and FSH-induced superovulation affect the expression of steroid hormone receptors and growth factors in caruncular tissue of non-pregnant sheep.

Oct 25, 2021

Implantation is a critical step in the establishment of pregnancy and an important part of embryo-maternal contact. Uterine receptivity can be affected by changes in body condition and the maternal en...

Evaluation of circulating Dickkopf-1 as a prognostic biomarker in ovarian cancer patients.

Oct 25, 2021

Dickkopf-1 (DKK1) is a secreted protein, known for suppressing the differentiation and activity of bone-building osteoblasts by acting as an inhibitor of Wnt-signalling. Soluble DKK1 (sDKK1) has been ...

Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis.

Oct 25, 2021

Endometriosis is a common non-malignant gynecological disease that significantly compromises fertility and quality of life of the majority of patients. The gold standard for diagnosis is visual inspec...

Sacituzumab govitecan in metastatic triple negative breast cancer (TNBC): Four design features in the ASCENT trial potentially favored the experimental arm.

Oct 25, 2021

The ASCENT trial reports impressive results with a median overall survival (OS) increased from 6.7 months to 12.1 months with sacituzumab govitecan over single-agent chemotherapy, in metastatic triple...

OLR1 is a prognostic factor and correlated with immune infiltration in breast cancer.

Oct 25, 2021

Oxidized low-density lipoprotein receptor 1 (OLR1), a key receptor for oxidized low-density lipoprotein (ox-LDL), plays a crucial role in cancer and inflammatory disease. However, the correlation betw...

Examining Anesthesia-Related Adverse Events in Obstetrics

Oct 21, 2021

 “Anesthesia-related adverse events (AEs) in obstetric populations in developed countries are infrequent but may be associated with significant maternal and neonatal morbidity and mortality,” exp...

Clinical Characteristics and Histologic Features of Hysterectomy Specimens

Oct 21, 2021

To define surgical pathology findings and discuss the clinical features of transmasculine people who had hysterectomy. Transmasculine patients having hysterectomy and bilateral salpingectomy or bilate...

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