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OB/GYN General

Changes in Nailfold Video capillaroscopy Are Linked to the Presence and Severity of Systemic Sclerosis–Related Interstitial Lung Disease

Dec 29, 2021

For this study, researchers wanted to see if there was a link between changes in nail fold video capillaroscopy (NVC) and the existence and severity of interstitial lung disease (ILD) in people with s...

Obesity Affects Ankle and Foot Joint Swelling in Patients With Early Rheumatoid Arthritis

Dec 29, 2021

The assessment of disease activity in obese rheumatoid arthritis (RA) patients provides unique complications, notably in the clinical examination of swollen joints. For this study researchers wanted t...

Previsit Rooming in Rheumatology Clinics: Assessing Unwanted Variations

Dec 29, 2021

Rheumatologists encounter time constraints comparable to primary care providers but have not benefited from optimum team-based rooming from the moment the patient enters the waiting room until the rhe...

Workforce Planning for Rheumatologists

Dec 29, 2021

Based on a nationwide workforce survey in rheumatology, for this study researchers wanted to investigate parameters linked with rheumatologists' clinical work hours and patient volumes. Adult rheumato...

Rheumatoid Arthritis-Related Mobile Apps

Dec 29, 2021

Mobile health applications (apps) have the potential to assist people with chronic diseases to learn about, monitor, and manage their conditions, but they are mostly unexplored, with the state and dir...

Chondroitin sulfate proteoglycan 4, a targetable oncoantigen that promotes ovarian cancer growth, invasion, cisplatin resistance and spheroid formation.

Dec 27, 2021

Epithelial ovarian cancer (EOC) is a highly heterogeneous disease encompassing several distinct molecular subtypes and clinical entities. Despite the initial success of surgical debulking and adjuvant...

Risks factors for anastomotic leakage in advanced ovarian cancer: A systematic review and meta-analysis.

Dec 27, 2021

This systematic review and meta-analysis aimed to summarise the available evidence on the pre- and intra-operative risk factors for anastomotic leakage (AL) after bowel resection and anastomosis for o...

Effect of postmastectomy radiotherapy on pTN breast cancer patients with different molecular subtypes.

Dec 27, 2021

To clarify the effect of postmastectomy radiotherapy (PMRT) on pTN breast cancer patients with different molecular subtypes.We retrospectively analyzed the data of 5442 patients with pTN breast cancer...

The Association of Estrogen Receptor Activity, Interferon Signaling, and MHC Class I Expression in Breast Cancer.

Dec 27, 2021

The expression of major histocompatibility complex class I (MHC I) has previously been reported to be negatively associated with estrogen receptor (ER) expression. Furthermore, MHC I expression, level...

Impact of Bladder Wall Thickness on the Outcomes of Antimuscarinic Treatment in Women with Overactive Bladder.

Dec 20, 2021

This study aimed to evaluate the effect of bladder wall thickness (BWT) (using transabdominal ultrasound) on the outcomes of antimuscarinic treatment in women with overactive bladder.A total of 102 fe...

Socioeconomic and Cognitive Roots of Trait Anxiety in Young Adults.

Dec 20, 2021

In 54 participants (41% women) from the Czech arm of the European Longitudinal Study of Pregnancy and Childhood, a national birth cohort with prospectively collected data from their birth until young ...

The Role of Delivery Route on Colostrum Melatonin and Serum Il-6 Levels: a Prospective Controlled Study.

Dec 20, 2021

the aim of this study was to determine whether maternal serum IL-6 and postnatal melatonin levels change with the mode of delivery.a prospective controlled study was performed on pregnant women (17-43...

The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study.

Dec 20, 2021

The aim of the study was to determine the risk of distant metastases in patients with gynecologic cancers after surgery, including cervical, uterine and ovarian cancers. This is a retrospective study ...

The role of dendritic cells in endometriosis: A systematic review.

Dec 20, 2021

Endometriosis (EDT), a common estrogen-dependent inflammatory disorder, is characterized by endometrial-like tissue outside the uterus. While its pathogenesis is poorly understood, it is supposed that...

Subgroup analyses demonstrate consistent OS benefit of ribociclib in patients with locally advanced/metastatic HR-positive/HER2-negative breast cancer

Dec 15, 2021

In three MONALEESA phase 3 trials, addition of ribociclib to adjuvant endocrine therapy improved overall survival (OS) in post-menopausal patients with locally advanced/metastatic HR-positive/HER2-neg...

Elacestrant may improve outcomes for patients whose metastatic breast cancer progressed on prior endocrine therapy

Dec 15, 2021

According to the first results of the EMERALD trial, elacestrant, the first oral selective estrogen receptor degrader, shows clinical benefit over standard endocrine therapy in patients with ER-positi...

Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab robustly benefits EFS in patients with early triple-negative breast cancer

Dec 15, 2021

Primary analysis of the KEYNOTE-522 trial shows a statistically significant and clinically meaningful improvement in the event-free survival (EFS) of neoadjuvant pembrolizumab plus chemotherapy follow...

Single-cell spatial analysis may help predict response to neoadjuvant immunotherapy in triple-negative breast cancer

Dec 15, 2021

A next-generation technology allows the study of protein expression at the single-cell level and the location of the cells within the tumor microenvironment (TME). In the NeoTRIPaPDL1 trial, it provid...

Addition of adjuvant palbociclib to standard endocrine therapy does not improve outcomes in patients with early HR-positive breast cancer

Dec 15, 2021

Although adjuvant therapy with CDK4/6 inhibitors has shown to benefit patients with advanced/metastatic HR-positive/HER2-negative breast cancer, the final analysis of the PALLAS trial shows no benefit...

Using genomics to match treatments improves outcomes for certain patients with metastatic breast cancer

Dec 15, 2021

The use of multigene sequencing as a therapeutic decision tool improved the outcomes for patients with metastatic breast cancer when the genomic alterations identified were ranked in the I/II tiers of...

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