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OB/GYN General

Treatment-driven tumour heterogeneity and drug resistance: Lessons from solid tumours.

Feb 14, 2022

Molecular heterogeneity characterizes tumours' evolution and adaptation and, because of its dynamics and continuous changes under external pressure, it is one of the major causes of drug resistance, c...

Understanding Patient Evaluation of Abnormal Uterine Bleeding (AUB): A Standardized Patient Case on AUB for OB/GYN Clerkship Students.

Feb 14, 2022

The differential diagnosis for abnormal uterine bleeding (AUB) among reproductive-age women is broad and includes common and life-threatening conditions. Recognition and accurate diagnosis of AUB are ...

Effect of Age on Complications Rate and Surgical Outcomes in Women Undergoing Laparoscopic Sacrohysteropexy and Sacrocolpopexy.

Feb 07, 2022

To compare perioperative and long-term outcomes of laparoscopic sacrohysteropexy/sacrocolpopexy in different groups of age.This was a retrospective cohort study. Patients were evaluated preoperatively...

Impact of urinary incontinence on anxiety status during pregnancy: A prospective case-control study.

Feb 07, 2022

To evaluate the impact of the presence and severity of urinary incontinence (UI) on pregnancy-related anxiety.This prospective case-control study included 160 pregnant women. Pregnant women with UI (n...

Effectiveness of cognitive behavioral therapy for perinatal maternal depression, anxiety and stress: A systematic review and meta-analysis of randomized controlled trials.

Feb 07, 2022

Cognitive behavioral therapy (CBT) has been widely studied in prenatal or postnatal depression, with much less research on anxiety and stress. This meta-analysis aims to comprehensively evaluate CBT e...

A functionalized graphene oxide with improved cytocompatibility for stimuli-responsive co-delivery of curcumin and doxorubicin in cancer treatment.

Feb 07, 2022

Nowadays, the usage of nanoparticles in various fields such as drug delivery, attracts the attention of many researchers in the treatment of cancers. Graphene oxide (GO) is one of the novel drug deliv...

Maintenance Therapy for Preventing Endometrioma Recurrence after Endometriosis Resection Surgery-A Systematic Review and Network Meta-analysis.

Feb 07, 2022

To evaluate the efficacy of different hormone therapies in preventing postoperative endometrioma recurrence.The MEDLINE, COCHRANE and Embase electronic databases were searched from inception to 30 Apr...

Nomogram for predicting the long-term outcomes of uterine artery embolization for adenomyosis.

Feb 07, 2022

The present study aimed to develop a nomogram to predict long-term outcomes of uterine artery embolisation (UAE) for treating adenomyosis.We reviewed data of 221 patients with adenomyosis who underwen...

Increase in ADAR1p110 activates the canonical Wnt signaling pathway associated with aggressive phenotype in triple negative breast cancer cells.

Feb 07, 2022

Triple-negative breast cancer (TNBC) represents a challenge in the search for new therapeutic targets. TNBCs are aggressive and generate resistance to chemotherapy. Tumors of TNBC patients with poor p...

Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships.

Feb 07, 2022

A new series of fifty-four 2-phenol-4-aryl-6-hydroxyphenylpyridines containing fluorophenyl, trifluoromethylphenyl, and trifluoromethoxy phenyl groups were synthesized and tested for topoisomerase IIÎ...

Medium term anatomical and functional outcomes following modified laparoscopic sacrocolpopexy.

Jan 31, 2022

We evaluated the anatomical and functional outcomes following modified laparoscopic sacrocolpopexy (LSC) utilizing deep dissection of the vaginal walls and distal mesh fixation at the anterior and pos...

The Development of F Fluorthanatrace: A PET Radiotracer for Imaging Poly (ADP-Ribose) Polymerase-1.

Jan 31, 2022

Fluorine 18 (F) fluorthanatrace (F-FTT) is a PET radiotracer for imaging poly (adenosine diphosphate-ribose) polymerase-1 (PARP-1), an important target for a class of drugs known as PARP inhibitors, o...

The clinical effectiveness and safety of traditional Chinese medicine Jinfeng pill in adjuvant treatment of infertility with polycystic ovary syndrome: A protocol for systematic review and meta-analysis.

Jan 31, 2022

Polycystic ovary syndrome (PCOS) is the main cause of infertility in women, the essence of which is an endocrine disorder syndrome with abnormal sugar metabolism and reproductive dysfunction, and the ...

Disruption of the pentraxin 3/CD44 interaction as an efficient therapy for triple-negative breast cancers.

Jan 31, 2022

Due to the heterogeneity and high frequency of genome mutations in cancer cells, targeting vital protumour factors found in stromal cells in the tumour microenvironment may represent an ideal strategy...

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta.

Jan 31, 2022

Triple-negative breast cancer (TNBC) is fast-growing and highly metastatic with the poorest prognosis among the breast cancer subtypes. Inactivation of glycogen synthase kinase 3 beta (GSK3β) plays a...

Professionalism in Family Planning Care Workshop.

Jan 31, 2022

When clinicians feel negative emotions toward patients, providinge patient-centered care can be difficult. This can occur in family planning scenarios, such as when a provider is uncomfortable with a ...

Gynaecologic Surgery Prophylactic Negative Pressure Wound Therapy After Laparotomy

Jan 25, 2022

For a study, researchers wanted to determine the efficacy of preventive negative pressure wound treatment in patients having laparotomy for gynecologic surgery. Researchers carried out a randomized co...

Obstetricians' Attitudes and Knowledge of Guidelines and Screening Tools to Reduce Opioid Use Following Childbirth

Jan 25, 2022

For a study, researchers wanted to investigate obstetricians' attitudes on adopting professional or regulatory guidelines, opioid risk-screening instruments, and recommendations for nonanalgesic thera...

Vital Sign Reference Ranges for Postpartum Women

Jan 25, 2022

Researchers wanted to estimate typical postpartum mother vital sign ranges for a study. They conducted a multicenter prospective longitudinal cohort research. They looked for women who were less than ...

Long-term Clinical Outcomes of Major Adverse Vascular Events Following Pregnancy Hypertensive Disorders

Jan 25, 2022

For a study, researchers wanted to investigate the relationship between hypertensive diseases of pregnancy and unfavorable postpartum outcomes, such as chronic kidney disease and serious adverse cardi...

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