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OB/GYN General

Using affected embryos to establish linkage phase in preimplantation genetic testing for thalassemia.

May 02, 2022

This study aimed to evaluate the ability of next-generation sequencing (NGS) to conduct preimplantation genetic testing (PGT) for thalassemia using affected embryos.This study included data from 36 co...

Bevacizumab-based Salvage Chemotherapy Improves Survival Outcomes for Patients With Brain Metastasis from Ovarian Cancer.

May 02, 2022

Brain metastases from ovarian cancer remain rare and the appropriate treatment is unknown. We investigated survival outcomes following salvage chemotherapy before and after bevacizumab approval to eva...

Differential roles of the Wip1-p38-p53 DNA damage response pathway in early/advanced-stage ovarian clear cell carcinomas.

May 02, 2022

Ovarian clear cell carcinoma (OCCC) is one of the most lethal types of ovarian cancer. Early-stage OCCC can be cured by surgery; however, advanced-stage disease shows poor prognosis due to chemoresist...

Decrease of Tumor-infiltrating Regulatory T Cells Using Pentoxifylline: An Ex Vivo Analysis in Triple-negative Breast Cancer Mouse Model.

May 02, 2022

Triple-negative breast cancer (TNBC) is the most aggressive type of BC with the highest percentage of tumor-infiltrating lymphocytes (TILs). Hence, TIL therapy is considered a promising approach to ta...

Interactions between meropenem and renal drug transporters.

May 02, 2022

Meropenem is a carbapenem antibiotic and commonly used with other antibiotics for the treatment of bacterial infections. It is primarily eliminated renally by glomerular filtration and renal tubular s...

Development of a Novel, Low-Cost, Low-Fidelity Simulation Model for Pudendal Nerve Block Application.

May 02, 2022

Pudendal nerve block is an important alternative to neuraxial anesthesia, yet studies demonstrate that 3% to 50% of pudendal nerve blocks are ineffective. Lack of clinician training is the most common...

A survey of specialty choice among obstetrics and gynecology residents in Japan, Korea, and Taiwan.

May 02, 2022

The percentage of medicine graduates opting for residency in obstetrics and gynecology (OB/GYN) has been decreasing in developed countries, including in Taiwan, Japan, and Korea. This multicountry stu...

Fertility-Sparing Surgery After Neo-adjuvant Chemotherapy in Women With Cervical Cancer Larger Than 4 cm

Apr 29, 2022

The aim of the study was to evaluate the oncologic and fertility results of women with cervix-confined cancer of more than 4 cm who received neoadjuvant chemotherapy followed by fertility-sparing surg...

Outcomes of Open Radical Hysterectomy Following Implementation of An ERAS Program

Apr 29, 2022

Open surgery has become the standard technique for radical hysterectomy (International Federation of Gynecology and Obstetrics (FIGO) 2018 IA1 with lymphovascular space invasion-IIA1). The goal of the...

Altered levels of neurobiological biomarkers at the interface of depression and gestational diabetes mellitus in Asian Indian women.

Apr 25, 2022

Gestational diabetes mellitus (GDM) might predispose the mothers to depression. Studies have reported the role of biomarkers either in GDM or depression, but very few have examined them in GDM with de...

Prevalence of Americans reporting a family history of cancer indicative of increased cancer risk: Estimates from the 2015 National Health Interview Survey.

Apr 25, 2022

The collection and evaluation of family health history in a clinical setting presents an opportunity to discuss cancer risk, tailor cancer screening recommendations, and identify people with an increa...

Estrogen valerate pretreatment with the antagonist protocol does not increase oocyte retrieval in patients with low ovarian response: a randomized controlled trial.

Apr 25, 2022

Does luteal phase estrogen valerate pretreatment improve oocyte yield and clinical outcomes in patients with low ovarian response during ovarian stimulation with the antagonist protocol?Pretreatment w...

Presence of adenomyosis at MRI reduces live birth rates in ART cycles for endometriosis.

Apr 25, 2022

What is the impact of adenomyosis on the live birth rate (LBR) in women affected by endometriosis women undergoing ART?For women undergoing ART, the presence of adenomyosis at MRI, especially T2 high-...

Long noncoding RNA KB-1980E6.3 promotes breast cancer progression through the PI3K/AKT signalling pathway.

Apr 25, 2022

This research aims to investigate the effect of lncRNA KB-1980E6.3 on the biological behaviour of breast cancer cells under normoxic conditions and the underlying molecular mechanism. The expression o...

The Modulatory Effect of Adipose-Derived Stem Cells on Endometrial Polyp Fibroblasts.

Apr 25, 2022

Endometrial polyps (EPs) are benign overgrowths of the endometrium, with the potential to cause severe complications, ranging from discomfort to inflammation and infertility. Dysfunction of endometria...

Compounds Enhancing Human Sperm Motility Identified Using a HTS Platform

Apr 18, 2022

There were several attempts to uncover tiny compounds that modulate sperm activity, but none have used high-throughput technologies. Semen samples from healthy donors were used, and samples were poole...

Metabolic State of Human Blastocysts Measured By Fluorescence Lifetime Imaging Microscopy (FLIM)

Apr 18, 2022

Embryo metabolism was connected to viability, implying that it could be helpful to in ART to aid in the selection of high-quality embryos. However, due to a lack of non-invasive technologies for measu...

Endometrial Gene Expression Related to Cilia & Aging

Apr 18, 2022

Endometrial transcriptome data from the Gene Expression Omnibus (GEO) sample repository was analyzed retrospectively in silico for 27 women of various aging. An independent gene expression dataset of ...

EndoTime: Luteal Endometrial Non-Categorical Timing Estimations

Apr 18, 2022

Endometrial timing methods based on gene expression that were commercially accessible required large gene sets and used a categorical approach that categorized samples as pre-receptive, receptive, or ...

Emulating a Target Trial to Compare the Efficacy of Clomiphene Citrate & Letrozole For Ovulation Induction

Apr 18, 2022

For a study, researchers sought to create a simulation of a hypothetical trial comparing the efficacy of letrozole against clomiphene citrate for ovulation induction in all women, then stratified by P...

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