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OB/GYN General

Targeting epidermal growth factor receptor in paclitaxel-resistant human breast and lung cancer cells with upregulated glucose-6-phosphate dehydrogenase.

May 23, 2022

Chemoresistance is a major obstacle to the successful treatment of triple-negative breast cancer (TNBC) and non-small-cell lung cancer (NSCLC). Therapeutic strategies to overcome chemoresistance are n...

Patient navigator team perceptions on the implementation of a citywide breast cancer patient navigation protocol: a qualitative study.

May 23, 2022

In 2018 Translating Research Into Practice (TRIP), an evidence-based patient navigation intervention aimed at addressing breast cancer care disparities, was implemented across six Boston hospitals. Th...

Hands-on Simulation Workshop for Obstetric Ultrasound-Guided Invasive Procedures.

May 23, 2022

Due to the introduction of cell-free DNA genetic testing options, the number of clinical ultrasound procedures has greatly diminished in recent years. With fewer real-life ultrasound-guided procedures...

Sexual Function Following Treatment for Stress Urinary Incontinence With Bulk Injection Therapy and Mid-Urethral Sling Surgery.

May 16, 2022

Peri-urethral bulking injections (PBI) gain popularity for the treatment of stress urinary incontinence (SUI), but - in contrast to mid-urethral sling (MUS) surgery - little is known about its impact ...

Association between use of ERAS protocols and complications after radical cystectomy.

May 16, 2022

Implementation of enhanced recovery protocols in cystectomy patients has significantly changed the perioperative course of this major operation. This paper summarizes evidence based interventions to e...

Developing guideline-based key performance indicators for recurrent miscarriage care: lessons from a multi-stage consensus process with a diverse stakeholder group.

May 16, 2022

Standardised care pathways tailored to women/couples who experience recurrent miscarriage are needed; however, clinical practice is inconsistent and poorly organised. In this paper, we outline our pro...

The enhancer RNA ADCY10P1 is associated with the progression of ovarian cancer.

May 16, 2022

Emerging evidence identifies enhancer RNAs (eRNAs) as a class of regulatory ncRNAs that can contribute to the transcription of target genes. In this study, we used an integrated data analysis method t...

Embryo morphological quality in relation to the metabolic and cognitive development of singletons conceived by in vitro fertilization/intracytoplasmic sperm injection: A matched cohort study.

May 16, 2022

Embryos with higher morphological quality may have a greater potential to achieve clinical pregnancy leading to live birth regardless of the type of cleavage-stage embryos or blastocysts. Few studies ...

Pre-analytical processing protocol of breast biopsies affects multigene panel results.

May 16, 2022

The creation of multigene panels for prognostic and predictive purposes allows a more accurate indication of adjuvant chemotherapy for patients with breast cancer. In a previous study, we reproduced a...

Having Heart: Affective and Cognitive Empathy Scores vs. Residency Specialty Match at an Osteopathic Medical School.

May 16, 2022

Past studies examining the cognitive empathy of medical school graduates grouped the various residency selections vs. parsing them out. This study examines both affective and cognitive empathy scores ...

Male Contraception is Coming: Who Do Men Want to Prescribe their Birth Control?

May 16, 2022

To assess men's preferences for type of healthcare provider from whom they would obtain hormonal male contraceptive (HMC) methods.We asked participants from three clinical trials of investigational ho...

Sacral Neuromodulation Using a Novel Device with a Six-contact-point Electrode for the Treatment of Patients with Refractory Overactive Bladder: A Multicenter, Randomized, Single-blind, Parallel-control Clinical Trial.

May 09, 2022

A novel sacral neuromodulation system (SacralStim) which has an electrode with six contact points was recently designed.To evaluate the effectiveness and safety of the SacralStim system for treating p...

Patterns of contraceptive use among young Australian women with chronic disease: findings from a prospective cohort study.

May 09, 2022

Given chronic disease is increasing among young women and unintended pregnancies among these women are associated with poor maternal and fetal outcomes, these women would benefit from effective precon...

LncRNA LINC00665 Promotes Ovarian Cancer Cell Proliferation and Inhibits Apoptosis via Targeting miR-181a-5p/FHDC.

May 09, 2022

Previous reports indicate that long intergenic non-coding RNA LINC00665 naturally occurred vital effects in various cancers. Herein, the role of LINC00665 in ovarian cancer progress was explored. We f...

FBXO2 targets glycosylated SUN2 for ubiquitination and degradation to promote ovarian cancer development.

May 09, 2022

SAD1/UNC84 domain protein-2 (SUN2) plays a tumor suppressor role in various types of cancer by inhibiting cancer cell proliferation, migration and promoting apoptosis. However, the post-translational ...

The effect of mildly stimulated cycle versus artificial cycle on pregnancy outcomes in overweight/obese women with PCOS prior to frozen embryo transfer: a retrospective cohort study.

May 09, 2022

Previous studies have shown that frozen embryo transfer (FET) resulted in increased live birth rates (LBR) and reduced the risk of ovarian hyperstimulation syndrome (OHSS) than did fresh embryo transf...

Operational complexity versus design efficiency: challenges of implementing a phase IIa multiple parallel cohort targeted treatment platform trial in advanced breast cancer.

May 09, 2022

Platform trial designs are used increasingly in cancer clinical research and are considered an efficient model for evaluating multiple compounds within a single disease or disease subtype. However, th...

Elevated transcription and glycosylation of B3GNT5 promotes breast cancer aggressiveness.

May 09, 2022

Basal-like breast cancer (BLBC) is the most aggressive subtype of breast cancer because of its aggressive biological characteristics and no effective targeted agents. However, the mechanism underlying...

Association between patient characteristics and HPV vaccination recommendation for postpartum patients: A national survey of Obstetrician/Gynecologists.

May 09, 2022

Human papillomavirus (HPV) vaccination rates in the U.S. are relatively low. Provider recommendation rates for HPV vaccination often vary by patient age and relationship status. Obstetrician/gynecolog...

Headaches in Pregnancy and Postpartum

May 06, 2022

For a study, researchers sought to give up-to-date evidence-based advice for the examination and management of primary and secondary headaches during pregnancy and after childbirth. Patients who were ...

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