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OB/GYN General

Evaluating the Relationship Between Fetal Acidosis and Obesity at Scheduled Cesarean Delivery

Dec 01, 2022

For a study, researchers sought to determine if obese individuals who have planned cesarean deliveries under neuraxial anesthesia were more likely to experience umbilical artery pH less than 7.1 and b...

After a Diagnosis of Breast Cancer, Evaluation of Obstetric and Neonatal Outcomes

Dec 01, 2022

For a study, researchers sought to assess the obstetric and neonatal outcomes of the first live birth delivered 1 or more years after receiving a breast cancer diagnosis. In a population-based anal...

Symptomatic Uterine Leiomyomas: Use of Long-term Relugolix Combination Therapy

Dec 01, 2022

Once-daily relugolix combination therapy was well tolerated and reduced menstrual blood loss volume and pain in women with heavy menstrual bleeding associated with uterine leiomyomas in the LIBERTY 1 ...

FMO2, a Fibroblast-derived Prognostic Predictor for Epithelial Ovarian Cancer

Nov 30, 2022

Fibroblasts were extracted from samples of EOC to use as a primary source. For this purpose, researchers obtained expression profiles from microdissection and single-cell RNA sequencing (scRNA-seq) da...

Circulating Metastases DNA Tracking for Ovarian Cancer Recurrence

Nov 30, 2022

The most deadly gynecologic cancer is epithelial ovarian cancer (EOC). Before surgery and during follow-up after therapy, researchers investigated whether circulating tumor DNA (ctDNA) could be a usef...

Endometrial Cancer CTNNB1 and MMP Mutations with Anti-angiogenesis Therapy

Nov 30, 2022

Biomarkers and treatment options for advanced and recurring illnesses are scarce. Although the mechanism of action of bevacizumab, an anti-angiogenesis medication, is uncertain, endometrial malignanci...

An Endometrial Cancer New Biomarker Based on CRABP2

Nov 29, 2022

For a study, the aim was to find out what role increased CRABP2 expression plays in the development and progression of endometrial cancer (EC). Using a decision tree classifier, patients were divided ...

Identification of Ovarian Cancer Therapeutic and Diagnostic Indicators Through Genomic Profiling

Nov 29, 2022

When compared to high grade serous ovarian cancer (HGSOC), low grade serous ovarian cancer (LGSOC) has distinct etiology, molecular, genetic, and clinical features. Limited testing, inconsistent histo...

DNA Methylation Profiling in the Blood for Ovarian Cancer Screening

Nov 29, 2022

Due to insufficient early detection methods, ovarian cancer remains a leading cause of death among gynecological malignancies. Therefore, DNA methylation profiling in blood samples was investigated fo...

HER2 Testing Platforms and Targeted Therapy Implications in Uterine Serous Carcinoma

Nov 28, 2022

Uterine serous carcinoma (USC) has HER2 as a major therapeutic and prognostic target. However, there is a lack of consensus on the best HER2 testing infrastructure, and testing recommendations have ev...

Splenectomy Outcomes During Cytoreductive Surgery for Epithelial Ovarian Cancer

Nov 28, 2022

Complications following cytoreductive surgery for Stage III or IV epithelial ovarian cancer with or without splenectomy are described, and opportunities for better post-splenectomy treatment are highl...

Pelvic Exenteration Outcomes: An Experience with the Brunschwig Procedure in the Current Era

Nov 28, 2022

For a study, it is essential to analyze the postoperative and oncologic results of pelvic exenteration for non-ovarian gynecologic cancers. From January 1, 2010, through December 31, 2019, researchers...

Advanced Ovarian Cancer Peritoneal Metastases Affect Surgery and Survival in Patients

Nov 25, 2022

Cytoreductive surgery (CRS) feasibility and the need for extensive surgery in patients with advanced ovarian cancer are difficult to assess. Therefore, it will be helpful to identify patients for CRS ...

How does PCC Improve the Wellbeing of Patients Receiving Treatment for Ovarian Cancer?

Nov 25, 2022

Ovarian cancer patients who report a higher level of patient-centered communication (PCC) have a higher health-related quality of life (HRQoL). TThe quantitative metrics of PCC and HRQoL does not well...

Mixed-methods Study on eSAC Use and Acceptability in Stage IV Ovarian Cancer

Nov 25, 2022

This study aimed to evaluate the feasibility and acceptability of a web-based patient reported outcome (PRO) program for persons with advanced ovarian cancer using electronic self-assessment and care ...

HIPEC after Neoadjuvant Chemotherapy Exhibited Tolerable Toxicity and QOL

Nov 24, 2022

Goal: to assess toxicity, quality of life, and progression-free survival (PFS) in patients with advanced ovarian cancer who underwent neoadjuvant chemotherapy (NAC) followed by CRS and HIPEC with carb...

Gemcitabine Plus Adavosertib or Placebo for Platinum-resistant Ovarian Cancer

Nov 24, 2022

A double-blind, randomized, placebo-controlled, phase 2 trial compared gemcitabine in combination with the WEE1 inhibitor adavosertib or placebo in patients with platinum-resistant or refractory high-...

Prexasertib (LY2606368) Phase 2 Trial for Platinum-resistant Ovarian Cancer

Nov 24, 2022

The most common type of ovarian cancer, high-grade serous ovarian cancer, has a dismal prognosis, and new treatments are desperately needed for individuals with platinum-resistant or -refractory disea...

Clinical Calculator Redefining the Prognosis for High-risk Early-Stage Ovarian Cancers

Nov 23, 2022

Among patients with early-stage high-risk epithelial ovarian cancer, researchers sought to evaluate the use of a clinical calculator in redefining prognosis and the need for treatment. Information on ...

Adjuvant Radiation Therapy Function in Older Patients with Node-positive Vulvar Cancer

Nov 23, 2022

This study's primary objective was to determine whether the survival benefit of adjuvant radiation for individuals with node-positive vulvar cancer is sustained in older patients. Patients aged 65 yea...

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