Feb 25, 2020

The data on the phenotypes associated with some rare germline mutations in Chinese breast cancer patients are limited. The difference in somatic mutation profiles in breast cancer patients with germli...

Feb 25, 2020

The germline cancer predisposition genes associated with increased risk of each clinical subtype of breast cancer, defined by estrogen receptor (ER), progesterone receptor (PR), and HER2, are not well...

Feb 25, 2020

Peptide modification is a popular strategy for developing an active targeting lipid nanoparticle (LNP). In modifying the surface of an LNP with a peptide, the sequence and structure of the peptide str...

Feb 25, 2020

Germline mutations in BRCA1 and BRCA2 (BRCA1/2) have been conventionally analyzed by Sanger sequencing and multiplex ligation-dependent probe amplification (MLPA). Nowadays, next-generation sequencing...

Feb 25, 2020

Metabolic syndrome (MetS) affects cognitive function in late-life, particularly in women. But longitudinal research is scarce on associations of MetS with cognitive function during midlife.Objective w...

Feb 25, 2020

To evaluate breast cancer (BC) molecular subtypes association with reproductive characteristics and an index of cumulative exposure to endogenous estrogens (EEI) in Mexican women.We performed a study ...

Feb 25, 2020

The increased incidence of depression in women going through peri-menopause suggests that fluctuations in estrogen levels may increase the risk of developing depression. Nonetheless, this psychiatric ...

Feb 25, 2020

The female gender is protected against immunological complications of endotoxemia. Here we investigated whether gonadal hormone depletion by ovariectomy (OVX) uncovers inflammatory and cardiovascular ...

Feb 25, 2020

There is limited data on the impact of bariatric surgery on polycystic ovarian syndrome (PCOS) especially in the Indian population.To study the impact of bariatric surgery in women with PCOS in terms ...

Feb 25, 2020

Endometriosis is a common inflammatory disease in women of reproductive age and is one of the major causes of infertility. Endometriosis causes a sustained reduction of ovarian reserve through both ph...

Feb 25, 2020

Morcellation of benign uterine tumors allows for removal of the tumors via minimally invasive laparoscopic procedures. However, in rare cases, morcellation has been associated with upstaging of unexpe...

Feb 25, 2020

Biomedicine has opened up new possibilities for parenthood. Once resigned to remaining childless or pursuing adoption, infertile couples can now pursue options such as gamete donation, in-vitro fertil...

Feb 25, 2020

Effects of lifestyle modification on reproductive function in polycystic ovary syndrome (PCOS) remains poorly elucidated. We compared the effects of a pulse-based diet (lentils, beans, split-peas, and...

Feb 25, 2020

Intracellular polyamines such as spermine and spermidine are essential to cell growth in normal and especially in cancer cells. However, whether extracellular polyamines affect cancer cell survival is...

Feb 25, 2020

In this study we have developed biodegradable polymeric nanoparticles (NPs) containing the cytostatic drugs mertansine (MRT) or cabazitaxel (CBZ).The NPs are based on chitosan (CS) conjugate polymers ...

Feb 25, 2020

Cephalostatin 1, a potent anti-cancer agent, is a natural bis-steroidal alkaloid that causes cell death in the subnanomolar to picomolar ranges via an atypical apoptosis pathway. Although cephalostati...

Feb 25, 2020

Many triple-negative breast cancers (TNBCs) show impaired breast cancer susceptibility gene I (BRCA1) function, called BRCAness. BRCAness tumors may show similar sensitivities to anticancer drugs as t...

Feb 25, 2020

Randomized trials have shown that initiating breast cancer screening between ages 50 and 69 years and continuing it for 10 years decreases breast cancer mortality. However, no trials have studied whet...

Feb 25, 2020

Medical school graduates should be able to enter information from patient encounters and to write orders and prescriptions in the electronic health record. Studies have shown that while students often...

Feb 25, 2020

Transgender men (TGM) are those who identify their sex as male but were assigned female at birth who face marginalization in obstetrics and gynecology (OB/GYN) practices. The following commentary high...