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OB/GYN General

BRD4 inhibition suppresses PD-L1 expression in triple-negative breast cancer.

Apr 28, 2020

Programmed death-ligand 1 (PD-L1) expression on the surface of tumour cells can cause tumour immune evasion. Benefits of combining anti-PD-L1 therapy with nab-paclitaxel in patients with advanced trip...

Breast Tumor Microenvironment: Emerging target of therapeutic phytochemicals.

Apr 28, 2020

Triple negative breast cancer (TNBC) is the most aggressive and challenging form of breast cancers. Tumor microenvironment (TME) of TNBC is associated with induction of metastasis, immune system suppr...

State or trait? Measuring resilience by generalisability theory in breast cancer.

Apr 28, 2020

Whether resilience should be conceptualised as a state or trait is debated. The precise distinction between state versus trait aspects of resilience can help identify dynamic targets for resilience-ba...

Can second-look ultrasound downgrade MRI-detected lesions? A retrospective study.

Apr 28, 2020

To determine whether MRI-detected suspicious (BIRADS 4 & 5) breast lesions can be downgraded using second-look ultrasound (SLU) and thus reduce unnecessarily performed breast biopsies.A retrospective ...

Real-World Data of Pyrotinib-Based Therapy in Metastatic HER2-Positive Breast Cancer: Promising Efficacy in Lapatinib-Treated Patients and in Brain Metastasis.

Apr 28, 2020

Pyrotinib is a newly-developed irreversible pan-ErbB receptor tyrosine kinase inhibitor. This study reported the first real-world data of pyrotinib-based therapy in metastatic human epidermal growth f...

OB/GYN Providers' Knowledge of Racial and Ethnic Reproductive Health Disparities.

Apr 28, 2020

This study explores OB/GYN providers' knowledge about published health and healthcare disparities in women's reproductive health.We collected demographic and health disparities knowledge information f...

Thiazolidinediones reduce the risk of hepatocellular carcinoma and hepatic events in diabetic patients with chronic hepatitis B.

Apr 28, 2020

Thiazolidinediones (TZDs) improve glycaemic control, and ameliorate liver steatosis, inflammation, and fibrosis in patients with fatty liver disease. We aimed to study the impact of TZD and glycaemic ...

Incidence of extrahepatic cancers among individuals with chronic hepatitis B or C virus infection: Anationwide cohort study.

Apr 28, 2020

This study examined the association between chronic HBV or HCV infection and the risk of extrahepatic cancers.A total of 537,103 adultsaged ≥20 years without history of cancer were identified from t...

Neutralization of IL-10 Produced by B Cells Promotes Protective Immunity during Persistent HCV Infection in Humanized Mice.

Apr 28, 2020

Chronic hepatitis C virus (HCV) infection can lead to cirrhosis and is associated with increased mortality. Interleukin (IL)-10-producing B cells (B10 cells) are regulatory cells that suppress cellula...

Real-time, functional intra-operative localization of rat cavernous nerve network using near-infrared cyanine voltage-sensitive dye imaging.

Apr 22, 2020

Despite current progress achieved in the surgical technique of radical prostatectomy, post-operative complications such as erectile dysfunction and urinary incontinence persist at high incidence rates...

Laparoscopic Long Mesh Surgery with Augmented Round Ligaments: A Novel Uterine Preservation Procedure For Apical Pelvic Organ Prolapse.

Apr 22, 2020

We aim to assess the surgical outcomes of our novel hysteropexy procedure, laparoscopic long mesh surgery (LLMS) with augmented round ligaments. Twenty-five consecutive women with stage II or greater ...

A STUDY OF DERMAL MELANOPHAGES IN CHILDHOOD NEVI.

Apr 22, 2020

In inflammatory dermatoses, dermal melanophages (MLP) are ascribed to "pigment incontinence", with melanin "dropping down" from the epidermis. Although this is analogous to the "dropping down" of mela...

Hyperglucosuria Induced by Dapagliflozin Augments Bacterial Colonization in the Murine Urinary Tract.

Apr 22, 2020

Diabetes is a leading risk factor for development of urinary tract infection (UTI). UTI caused by uropathogenic Escherichia coli (UPEC), and other uropathogens is a common infectious condition affecti...

Same-Day Discharge and Quality of Life for Primary Laparoscopic Rectopexy for Rectal Prolapse in Children: A 10-Year Experience.

Apr 22, 2020

Rectal prolapse (RP) in pediatric patients may require surgical intervention. Varying surgical approaches and heterogenous patient populations have resulted in difficulty defining surgical outcomes a...

Hepatitis B virus seroepidemiology data for Africa: Modelling intervention strategies based on a systematic review and meta-analysis.

Apr 22, 2020

International Sustainable Development Goals (SDGs) for elimination of hepatitis B virus (HBV) infection set ambitious targets for 2030. In African populations, infant immunisation has been fundamental...

Prognostic significance of neutrophil-to-lymphocyte ratio in HPV status era for oropharyngeal cancer.

Apr 22, 2020

To evaluate the role of baseline neutrophil-to-lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemo-radiotherapy (CRT) in the er...

Prevalence, incidence and associated factors for HBV infection among male and female prisoners in Central Brazil: a multicenter study.

Apr 22, 2020

Prison population are at high risk for hepatitis B virus (HBV) infection. The aim of this study was to assess the prevalence, incidence, HBV associated factors and the circulating genotypes/subtypes.A...

Compliance with international guidelines in adults with encephalitis.

Apr 22, 2020

Encephalitis is associated with significant neurological disability and mortality. Many guidelines are published for encephalitis management but compliance with them is unknown.To evaluate the appropr...

Improving immunogenicity and safety of flagellin as vaccine carrier by high-density display on virus-like particle surface.

Apr 22, 2020

Flagellin is a protein-based adjuvant that activates toll-like receptor (TLR) 5. Flagellin has been actively explored as vaccine adjuvants and carriers. Preclinical and clinical studies find flagellin...

Reproduction and Pregnancy in Inflammatory Bowel Disease - Management and Treatment Based on Current Guidelines.

Apr 22, 2020

Inflammatory bowel diseases (IBD) affect mainly young population. Therefore, fertility and pregnancy are important clinical issues to be considered. Generally, fertility in IBD patients is not decreas...

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