Somatic genome editing with the RCAS-TVA-CRISPR-Cas9 system for precision tumor modeling.
Nature communications 2018 04 139(1) 1466 doi 10.1038/s41467-018-03731-w Abstract To accurately...
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PubMed
A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes.
Nature communications 2018 04 129(1) 1438 doi 10.1038/s41467-018-03939-w Abstract Autophagy is a...
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n-3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease.
The New England journal of medicine 2018 04 13() doi 10.1056/NEJMoa1709691 Abstract Background Dry...
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ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle.
Cell 121(4) 553-565 pii 10.1016/j.cell.2005.03.028 Abstract ATP hydrolysis is required for...
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A TAD boundary is preserved upon deletion of the CTCF-rich Firre locus.
Nature communications 2018 04 139(1) 1444 doi 10.1038/s41467-018-03614-0 Abstract The binding of...
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Comprehensive Characterization of Cancer Driver Genes and Mutations.
Cell 173(2) 371-385.e18 pii 10.1016/j.cell.2018.02.060 Abstract Identifying molecular cancer...
Read MoreA Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples.
Cell 173(2) 386-399.e12 pii 10.1016/j.cell.2018.03.027 Abstract The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection...
Read MoreEffectiveness and Safety of Apixaban, Dabigatran, and Rivaroxaban Versus Warfarin in Frail Patients With Nonvalvular Atrial Fibrillation.
Journal of the American Heart Association 2018 04 137(8) pii 10.1161/JAHA.118.008643 Abstract BACKGROUND Frailty predicts poorer outcomes and decreased anticoagulation use in patients with nonvalvular atrial fibrillation. We...
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Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of...
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The Immune Landscape of Cancer.
Immunity 2018 04 0548(4) 812-830.e14 pii 10.1016/j.immuni.2018.03.023 Abstract We performed an...
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An efficient and scalable pipeline for epitope tagging in mammalian stem cells using Cas9 ribonucleoprotein.
eLife 2018 04 117() doi 10.7554/eLife.35069 Abstract CRISPR/Cas9 can be used for precise genetic...
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Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort.
The Lancet. Oncology 2018 05 09() pii 10.1016/S1470-2045(18)30242-0 Abstract BACKGROUND...
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The SCF Slimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication.
The Journal of cell biology 184(2) 225-39 doi 10.1083/jcb.200808049 Abstract Restricting centriole...
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Identifying novel strategies for treating human hair loss disorders: Cyclosporine A suppresses the Wnt inhibitor, SFRP1, in the dermal papilla of human scalp hair follicles.
PLoS biology 2018 05 0816(5) e2003705 doi 10.1371/journal.pbio.2003705 Abstract Hair growth...
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The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4.
Current biology : CB 2008 12 1119(1) 43-9 doi 10.1016/j.cub.2008.11.037 Abstract Centrioles are...
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Assessing and maximizing data quality in macromolecular crystallography.
Current opinion in structural biology 2015 07 2434() 60-8 doi 10.1016/j.sbi.2015.07.003 Abstract...
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Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors.
Stem cell reports 10(5) 1505-1521 pii 10.1016/j.stemcr.2018.04.009 Abstract Skeletal muscle...
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Patient-Derived iPSCs and iNs-Shedding New Light on the Cellular Etiology of Neurodegenerative Diseases.
Cells 2018 05 087(5) pii 10.3390/cells7050038 Abstract Induced pluripotent stem cells (iPSCs) and...
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Cryo-EM structure of the adenosine A receptor coupled to an engineered heterotrimeric G protein.
eLife 2018 05 047() doi 10.7554/eLife.35946 Abstract The adenosine A receptor (AR) is a...
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Cause of Cambrian Explosion – Terrestrial or Cosmic?
Progress in biophysics and molecular biology 2018 03 13() pii 10.1016/j.pbiomolbio.2018.03.004...
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