PubMed

Nucleic acids research 2018 06 07() doi 10.1093/nar/gky505 Abstract Genome editing technology based on engineered nucleases has been increasingly applied for targeted modification of genes in a variety of cell types and...

Clinical pediatrics 30(7) 441-5 Abstract Test anxiety is severely disabling to students whose fear of examinations causes cognitive dysfunction that paralyzes their thinking the way stage fright impairs actors ability to act. In...

Scientific reports 2018 05 258(1) 8171 doi 10.1038/s41598-018-25837-3 Abstract Macrophages (MΦs) are involved in folliculogenesis and ovulation. However, it is unknown which type of MΦ, M1 or M2, plays a more essential role in...

Nature 2018 05 21558(7708) 95-99 doi 10.1038/s41586-018-0143-x Abstract The Peltier effect, discovered in 1834, converts a charge current into a heat current in a conductor, and its performance is described by the Peltier...

Cell 2018 05 11() pii 10.1016/j.cell.2018.04.028 Abstract Degrons are minimal elements that mediate the interaction of proteins with degradation machineries to promote proteolysis. Despite their central role in proteostasis, the...

Nature 2018 05 16557(7707) 724-728 doi 10.1038/s41586-018-0119-x Abstract Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS). Microglia modulate pro-inflammatory and...

Nature 2018 05 16557(7706) 575-579 doi 10.1038/s41586-018-0130-2 Abstract Various forms of immunotherapy, such as checkpoint blockade immunotherapy, are proving to be effective at restoring T cell-mediated immune responses that...

Sports medicine (Auckland, N.Z.) 2018 05 18() doi 10.1007/s40279-018-0938-9 Abstract Ironman triathlons are ultra-endurance events of extreme duration. The performance level of those competing varies dramatically, with elite...

Nature reviews. Cancer 2018 05 21() doi 10.1038/s41568-018-0015-6 Abstract In this Review, I present evidence supporting a multifactorial causation of childhood acute lymphoblastic leukaemia (ALL), a major subtype of paediatric...

Nature 2018 05 16557(7706) 585-589 doi 10.1038/s41586-018-0128-9 Abstract The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth that responds to a diverse set of environmental cues,...

Nature communications 2018 06 069(1) 2197 doi 10.1038/s41467-018-04564-3 Abstract Eukaryotic cells employ the ribosome-associated quality control complex (RQC) to maintain homeostasis despite defects that cause ribosomes to...

PloS one 2018 06 1813(6) e0198166 doi 10.1371/journal.pone.0198166 Abstract Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP)...

International journal of molecular sciences 2018 06 0619(6) pii 10.3390/ijms19061689 Abstract Parkinson’s disease (PD) is a progressively debilitating neurodegenerative disease characterized by α-synucleinopathy,...

Nature communications 2018 06 089(1) 2231 doi 10.1038/s41467-018-04651-5 Abstract CRISPR advances genome engineering by directing endonuclease sequence specificity with a guide RNA molecule (gRNA). For precisely targeting a gene...

Frontiers in oncology 2018 05 248() 161 doi 10.3389/fonc.2018.00161 Abstract Advances in chemotherapy and targeted therapies have improved survival in cancer patients with an increase of the incidence of newly diagnosed brain...

Journal of hepatology 2018 06 07() pii 10.1016/j.jhep.2018.05.036 Abstract BACKGROUND Nonalcoholic fatty liver disease (NAFLD) with resulting nonalcoholic steatohepatitis (NASH) are increasingly a cause of cirrhosis and...

Molecular cell 2018 06 0770(5) 854-867.e9 pii 10.1016/j.molcel.2018.05.001 Abstract RNA binding proteins (RBPs) orchestrate the production, processing, and function of mRNAs. Here, we present the affinity landscapes of 78 human...

The Journal of physiology 2016 06 30594(18) 5329-42 doi 10.1113/JP272453 Abstract KEY POINTS A recent 30 year prospective study showed that lifelong sauna use reduces cardiovascular-related and all-cause mortality; however, the...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

Genes & development 2018 06 2732(13-14) 929-943 doi 10.1101/gad.313932.118 Abstract While a mutation in is the most common genetic contributor to amyotrophic lateral sclerosis (ALS), much remains to be learned concerning...