PubMed

Cell reports 24(2) 429-440 pii 10.1016/j.celrep.2018.06.042 Abstract Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a...

The New England journal of medicine 379(2) 138-149 doi 10.1056/NEJMoa1714021 Abstract BACKGROUND Recent Mycobacterium tuberculosis infection confers a predisposition to the development of tuberculosis disease, the leading killer...

Cell reports 24(2) 320-328 pii 10.1016/j.celrep.2018.06.047 Abstract The flavivirus genus comprises major human pathogens, such as Dengue (DENV) and Zika (ZIKV) viruses. RIG-I and MDA5 are key cytoplasmic pathogen recognition...

Neurobiology of stress 2018 05 199() 9-21 doi 10.1016/j.ynstr.2018.05.003 Abstract Microglia are the predominant immune cells of the central nervous system (CNS) that exert key physiological roles required for maintaining CNS...

Nature communications 2018 07 069(1) 2643 doi 10.1038/s41467-018-05067-x Abstract CRISPR-Cas9-based gene activation (CRISPRa) is an attractive tool for cellular reprogramming applications due to its high multiplexing capacity...

Journal of the International Society of Sports Nutrition 2018 07 0915(1) 31 doi 10.1186/s12970-018-0236-9 Abstract BACKGROUND Ketogenic diets (KD) have become a popular method of promoting weight loss. More recently, some have...

Nature communications 2018 07 069(1) 2641 doi 10.1038/s41467-018-05073-z Abstract RNA-based drugs depend on chemical modifications to increase potency and to decrease immunogenicity in vivo. Chemical modification will likely...

Cancer science 2018 07 07() doi 10.1111/cas.13726 Abstract Recent years have seen a number of regulatory approvals for immune oncology or immunotherapies based on their ability to enhance anti-tumor immune responses....

Acta neuropathologica communications 2018 07 046(1) 55 doi 10.1186/s40478-018-0555-8 Abstract A hexanucleotide (GGGGCC) repeat expansion in C9ORF72 is the most common genetic contributor to amyotrophic lateral sclerosis (ALS)...

Nature communications 2018 06 309(1) 2447 doi 10.1038/s41467-018-04907-0 Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for...

eLife 2018 07 037() doi 10.7554/eLife.36402 Abstract Parkinson’s disease is a progressive neuropathological disorder that belongs to the class of synucleopathies, in which the protein alpha-synuclein is found at abnormally...

The New England journal of medicine 2018 05 22() doi 10.1056/NEJMoa1803538 Abstract Background We hypothesized that fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) would be superior to medical...

The New England journal of medicine 2018 05 21() doi 10.1056/NEJMoa1804093 Abstract Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13...

The New England journal of medicine 2018 05 21() doi 10.1056/NEJMoa1804092 Abstract Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13...

Current biology : CB 2018 05 1728(11) 1714-1724.e4 pii 10.1016/j.cub.2018.04.015 Abstract Intermittent fasting (IF) can improve function and health during aging in laboratory model organisms, but the mechanisms at work await...

Surgical neurology international 2018 04 269() 91 doi 10.4103/sni.sni_45_18 Abstract Background Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC...

Journal for immunotherapy of cancer 2018 05 166(1) 39 doi 10.1186/s40425-018-0349-3 Abstract Immunotherapy is among the most rapidly evolving treatment strategies in oncology. The therapeutic potential of immune-checkpoint...

Journal of sports science & medicine 2018 05 1417(2) 259-268 Abstract The purpose of the study was to examine the effects of altering from habitual mixed Western-based (HD) to a very low-carbohydrate high-fat (VLCHF) diet...

Journal of sports science & medicine 2018 05 1417(2) 167-173 Abstract The effects of concurrent strength and endurance training have been well studied in untrained and moderately-trained individuals. However, studies...

Viruses 2010 02 052(2) 574-600 doi 10.3390/v2020574 Abstract The C-C chemokine receptor type 5 (CCR5) is a key player in HIV infection due to its major involvement in the infection process. Investigations into the role of the...