PubMed

The Journal of clinical investigation 2019 02 12() doi 10.1172/JCI96313 Abstract Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer...

PeerJ 2019 02 057() e6273 doi 10.7717/peerj.6273 Abstract Background Low-carbohydrate, high-fat (LCHF) diets are useful for treating a range of health conditions, but there is little research evaluating the degree of...

Genome biology 2019 02 1120(1) 30 doi 10.1186/s13059-019-1644-0 Abstract BACKGROUND Alternative splicing is a key regulatory mechanism in eukaryotic cells and increases the effective number of functionally distinct gene...

eLife 2019 02 128() doi 10.7554/eLife.40811 Abstract Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show...

Resuscitation 2014 06 0285(9) 1204-11 doi 10.1016/j.resuscitation.2014.04.029 Abstract Hypothermic cardiac arrest has high mortality and few known prognostic factors. We studied retrospectively 34 victims of accidental...

Immunity 2019 01 23() pii 10.1016/j.immuni.2019.01.001 Abstract Non-lymphoid tissues (NLTs) harbor a pool of adaptive immune cells with largely unexplored phenotype and development. We used single-cell RNA-seq to characterize...

Journal of clinical medicine 2019 02 078(2) pii 10.3390/jcm8020207 Abstract The immune system acting via cancer immune-surveillance is considered a potential target for improving outcomes among some malignancies. The ability to...

Gastroenterology 2019 02 06() pii 10.1053/j.gastro.2019.01.261 Abstract BACKGROUND & AIMS In a phase 3 trial (RESORCE), regorafenib increased overall survival compared with placebo in patients with hepatocellular carcinoma...

Nature communications 2019 02 0810(1) 688 doi 10.1038/s41467-019-08405-9 Abstract Corticosteroids are host-directed drugs with proven beneficial effect on survival of tuberculosis (TB) patients, but their precise mechanisms of...

Nature communications 2019 02 0810(1) 650 doi 10.1038/s41467-018-08247-x Abstract During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized...

The journals of gerontology. Series A, Biological sciences and medical sciences 72(12) 1595-1606 doi 10.1093/gerona/glx089 Abstract Older men (n = 12) and women (n = 18) 65-80 years of age completed 12 weeks of exercise and took...

Cell reports 26(6) 1598-1613.e8 pii 10.1016/j.celrep.2019.01.036 Abstract Flaviviruses cause systemic or neurotropic-encephalitic pathology in humans. The flavivirus nonstructural protein 1 (NS1) is a secreted glycoprotein...

Cell reports 26(6) 1544-1556.e8 pii 10.1016/j.celrep.2019.01.043 Abstract The tripeptide glutathione suppresses the iron-dependent, non-apoptotic cell death process of ferroptosis. How glutathione abundance is regulated in the...

Frontiers in genetics 2019 01 229() 712 doi 10.3389/fgene.2018.00712 Abstract Amyotrophic lateral sclerosis (ALS) is the most common adult-onset motor neuron disease and is characterized by the degeneration of upper and lower...

Cell reports 26(6) 1585-1597.e4 pii 10.1016/j.celrep.2019.01.052 Abstract Spondweni virus (SPOV) is the flavivirus that is most closely related to Zika virus (ZIKV). Although SPOV causes sporadic human infections in Africa,...

Advances in nutrition (Bethesda, Md.) 10(suppl_1) S31-S48 doi 10.1093/advances/nmy037 Abstract The consumption of sugar-free foods is growing because of their low-calorie content and the health concerns about products with high...

Genome biology 2018 10 0819(1) 160 doi 10.1186/s13059-018-1531-0 Abstract BACKGROUND Recent genome-wide association studies (GWAS) have identified more than 100 loci associated with increased risk of prostate cancer, most of...

Proceedings of the National Academy of Sciences of the United States of America 2018 10 08() pii 10.1073/pnas.1802166115 Abstract Programmed death-ligand 1 (PD-L1) expression on tumor cells (TCs) by immunohistochemistry is...

JCI insight 2018 10 043(19) doi 10.1172/jci.insight.122467 Abstract Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) targeting neoantigens can mediate tumor regression in selected patients with metastatic...

The New England journal of medicine 2018 09 25() doi 10.1056/NEJMoa1809064 Abstract BACKGROUND Enhancing tumor-specific T-cell immunity by inhibiting programmed death ligand 1 (PD-L1)-programmed death 1 (PD-1) signaling has...