PubMed

The potential of gene delivery for the treatment of traumatic brain injury.

Jul 29, 2024

Therapeutics for traumatic brains injuries constitute a global unmet medical need. Despite the advances in neurocritical care, which have dramatically improved the survival rate for the ~ 70 million patients annually, few...

A Protease from Moringa oleifera Lam. Exhibits In-vitro Blood Clot Solubilization and Fibrin Hydrolysis.

Jul 29, 2024

Thrombosis is the formation of abnormal blood clots in the blood vessels that obstruct blood flow and lead to thrombosis. Current treatments for thrombosis are associated with serious side effects. Therefore there is a need for...

Spontaneous suprachoroidal haemorrhage: clinical features, visual outcomes and prognosis factors.

Jul 29, 2024

To describe clinical features, risk factors and outcomes of patients with diagnosis of rare spontaneous suprachoroidal haemorrhage (SSCH) over a 20-year period from a tertiary eye unit.Retrospective, observational case-series of...

Preclinical evaluation of tissue-selective gene therapies for congenital generalised lipodystrophy.

Jul 29, 2024

Lipodystrophy is a rare disorder which can be life-threatening. Here individuals fail to develop or maintain appropriate adipose tissue stores. This typically causes severe metabolic complications, including hepatic steatosis...

Target analysis and identification of curcumin against vascular calcification.

Jul 29, 2024

To investigate the mechanism of curcumin (CUR) on vascular calcification (VC), we screen for common targets of CUR and atherosclerosis and verify the targets genes in vivo and in vitro experiments. The common targets of CUR and...

The Effect of New Trend Electronic Cigarettes on Dental Caries in Relation to Glucosyltransferase B and Secretory Immunoglobulin A (A Case-control Study).

Jul 29, 2024

Electronic cigarettes (vapes) are actively used, and their use is growing globally, especially among young people. Its spread is rapid due to the presence of unproven rumors that it is used to treat smoking addiction as it aids...

Dairy consumption and vitamin D concentration in adolescents with challenge-confirmed cow’s milk allergy during infancy.

Jul 29, 2024

Milk is an important source of dietary calcium and, if fortified, vitamin D. Cow’s milk allergy (CMA) is treated with a milk elimination diet. Although most children become tolerant by age 3 years, some continue dairy...

Moderate-to-severe cognitive impairment is associated with both recent and chronic alcohol misuse in people with HIV: The New Orleans alcohol use in HIV (NOAH) study.

Jul 28, 2024

Human immunodeficiency virus (HIV) profoundly impacts the nervous system, leading to neurological deficits including HIV-associated neurocognitive disorder (HAND). HAND represents the most common neurological comorbidity among...

Association between striatal amyloid deposition and motor prognosis in Parkinson’s disease.

Jul 22, 2024

The co-occurrence of amyloid-β pathology in Parkinson’s disease (PD) is common; however, the role of amyloid-β deposition in motor prognosis remains elusive. This study aimed to investigate the association between striatal...

Comorbidity of bipolar disorder and borderline personality disorder: Phenomenology, course, and treatment considerations.

Jul 22, 2024

Bipolar disorder (BD) and borderline personality disorder (BPD) are both serious psychiatric conditions that elevate the risk for harmful outcomes. Although these conditions represent distinct diagnostic entities, existing...

Protocolized Foot Exercises Help in Improvement of Diabetic Foot Ulcers and Quality of Life When Added to Standard Therapy-A Randomized Clinical Trial.

Jul 22, 2024

Diabetic foot disease is the major cause of nontraumatic limb amputations worldwide causing a high socioeconomic and psychological toll and a huge burden to the healthcare system. Currently, standard treatment of diabetic foot...

Repeatability and agreement of total corneal astigmatism measured in keratoconic eyes using four current devices.

Jul 22, 2024

To evaluate repeatability and agreement in measurements of total corneal astigmatism (TCA) in keratoconic eyes, using four optical coherence tomography (OCT)-based devices: Anterion, Casia SS-1000, IOLMaster 700, and MS-39.Three...

Genotype Phenotype Correlation of Renal Tumors in the Cancer Genome Atlas Database.

Jul 22, 2024

Morphological features are critical in evaluation of renal tumors and directing molecular workup. The objective of this study was to review histomorphology of renal tumors with molecular alterations of known subtypes. Renal...

Impact of dinoprostone versus cook cervical ripening balloon on induction in pregnancies complicated by small-for-gestational-age fetuses at term.

Jul 22, 2024

To explore the complications and pregnancy outcomes of vaginal dinoprostone vs. Cook’s double balloon for the induction of labor among pregnancies complicated by small-for-gestational-age (SGA) at term.This retrospective...

Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer.

Jul 22, 2024

Cisplatin is integral to ovarian cancer treatment, yet resistance to this drug often results in adverse patient outcomes. The association of circular RNA (circRNA) with cisplatin resistance in ovarian cancer has been observed,...

Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia.

Jul 22, 2024

Proliferative breast atypical lesions, including atypical ductal hyperplasia (ADH) and lobular intraepithelial neoplasms (LIN), represent benign entities that confer an elevated risk of ductal carcinoma in situ (DCIS) and...

Minimal important difference of the Migraine Disability Assessment (MIDAS): Longitudinal data from the DMKG Headache Registry.

Jul 22, 2024

The Migraine Disability Assessment (MIDAS) is widely used. However, there are limited data on how much a reduction in the MIDAS score indicates a change that matters to the patient.Data from the DMKG (i.e. German Migraine and...

Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder.

Jul 22, 2024

Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder that has been found to be associated with dysregulation of gastrointestinal functions and gut microbial homeostasis (the so-called “gut-brain...

The use of serum paraoxonase-1 to assess inflammation in horses with colitis serum paraoxonase-1 in horses with colitis.

Jul 22, 2024

Paraoxonase-1 (PON-1) has been suggested as a marker of inflammation and oxidative stress in horses and could potentially be used for prognostication in horses with colitis.Assessment of PON-1 in horses with colitis and...

Cholesterol Embolic Renal Disease: Experience of a Large Healthcare System.

Jul 22, 2024

To determine the clinical-pathological features associated with cholesterol embolic renal disease, and review of literature. This retrospective case series includes patients with cholesterol embolic renal disease (10 of 3087...

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