Advances in endotoxin analysis.
The outer membrane of gram-negative bacteria is primarily composed of lipopolysaccharide (LPS). In addition to protection, LPS defines the distinct serogroups used to identify bacteria speci...
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Exploration and validation of signature genes and immune associations in septic cardiomyopathy.
An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connec...
Risk factors and predicting nomogram for the clinical deterioration of non-severe community-acquired pneumonia.
Currently, there remains insufficient focus on non-severe community-acquired pneumonia (CAP) patients who are at risk of clinical deterioration, and there is also a dearth of research on the...
Diagnosis and management of complications following pelvic organ prolapse surgery using a synthetic mesh: French national guidelines for clinical practice.
Complications associated with pelvic organ prolapse (POP) surgery using a synthetic non-absorbable mesh are uncommon (<5%) but may be severe and may hugely diminish the quality of life of...
Knowledge, Attitudes, Practices and Perceived Challenges for Healthcare Workers on Water-Less ICU Care at a Neonatal Intensive Care Unit in Singapore.
Implementation of water-less care, including removal of sinks from patient care areas, is an emerging approach to reduce water-borne infections in high-risk areas such as intensive care unit...
A retrospective analysis of concussion and post-concussional syndrome diagnoses in Western Australian emergency departments.
To determine the rate of concussion diagnoses per capita recorded in hospital emergency departments in Western Australia (WA) from 2002-2018 for ICD-10-AM concussion diagnoses S06.00-S06.05,...
Firearm storage practices among military veterans in the United States: Findings from a nationally representative survey.
Unsafe storage of firearms is associated with heightened risk of suicide among veterans. However, contemporary population-based data on the prevalence and correlates of firearm storage pract...
D-ribose metabolic disorder and diabetes mellitus.
D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays a c...
PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.
Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However, its clinical application is limited due to severe side effects such as cardiotoxicity. In recent yea...
Oral anticoagulant safety in family practice: prognostic accuracy of Bleeding Risk Scores (from the CACAO study).
To assess bleeding risk of patients treated by oral anticoagulants, several scores have been constructed to assist physicians in the evaluation of the benefit risk. Most of these scores lack...
Prospective analysis of pre and postoperative laboratory parameters associated with thrombosis in patients with ovarian cancer.
Patients with ovarian cancer have a high risk of developing thrombosis. We aimed to investigate pre and post operative biomarkers associated with thrombosis including deep vein thrombosis an...
Prevalence of Guideline Discordant Aspirin use and Associated Adverse Events in Patients on Warfarin for Mechanical Valve Replacement.
For patients on warfarin for mechanical heart valve replacement, the 2020 American College of Cardiology and American Heart Association Guidelines recommend only adding aspirin in patients w...
Anticoagulant prescribing patterns in patients with primary central nervous system malignancies and secondary metastases.
To evaluate the safety of direct oral anticoagulants (DOACs) versus low-molecular weight heparin (LMWH) in patients with central nervous system (CNS) malignancies and secondary metastases. A...
Quantifying the Benefit-Risk Trade-Off for Individual Patients in a Clinical Trial: Principles and Anti-Thrombotic Case Study.
A treatment's overall favourable benefit-risk profile does not imply that every individual patient will benefit from the treatment. We describe a statistical methodology for quantifying the ...
Bayesian Mendelian randomization with an interval causal null hypothesis: ternary decision rules and loss function calibration.
We enhance the Bayesian Mendelian Randomization (MR) framework of Berzuini et al. (Biostatistics 21(1):86-101, 2018) by allowing for interval null causal hypotheses, where values of the cau...
Association between dietary diversity and chronic kidney disease in community-dwelling older adults.
The present study examined whether dietary diversity is associated with chronic kidney disease (CKD) in community-dwelling older Japanese adults.Participants comprised 8,195 older adults (me...
Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results.
The aim of this sub-study was to evaluate the relationship between echocardiography (echo) and cardiac magnetic resonance imaging (cMRI) variables and to utilize echo to assess the effect of...
Is catheter ablation associated with preservation of cognitive function? An analysis from the SAGE-AF observational cohort study.
To examine the associations between catheter ablation treatment (CA) vs. medical management and cognitive impairment among older adults with atrial fibrillation (AF).Ambulatory patients who ...
Preventive cardiology for the aging population: how can we better design clinical trials of statins?
Older adults form a fast-increasing proportion of the world population. However, gains in increasing quantity of life have not been accompanied by similar gains in quality of life. Older peo...
Association between a polygenic lipodystrophy genetic risk score and diabetes risk in the high prevalence Maltese population.
Type 2 diabetes (T2DM) is genetically heterogenous, driven by beta cell dysfunction and insulin resistance. Insulin resistance drives the development of cardiometabolic complications and is ...
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