Hematology/Oncology

microRNA-141-3p-containing small extracellular vesicles derived from epithelial ovarian cancer cells promote endothelial cell angiogenesis through activating the JAK/STAT3 and NF-κB signaling pathways.

Feb 10, 2020

Paracrine signaling between tumor and surrounding stromal cells is critical for the maintenance of...

Synergistic Antitumor Effects in Drug-Resistant Ovarian Cancer

Feb 10, 2020

Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional...

Knockdown of enhancer of rudimentary homolog inhibits proliferation and metastasis in ovarian cancer by regulating epithelial-mesenchymal transition.

Feb 10, 2020

Ovarian cancer (OC) is the deadliest gynecological malignancy. The pathogenesis of molecular in...

Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.

Feb 4, 2020

Ovarian cancer has the highest mortality rate among all gynecological cancers with its pathogenic...

Coping with Fear of Cancer Recurrence Among Ovarian Cancer Survivors

Feb 4, 2020

Fear of cancer recurrence (FCR) is a paramount concern among ovarian cancer survivors. Evidence...

Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p/ROCK2 axis.

Feb 4, 2020

Long non-coding RNA (lncRNA) TTN antisense RNA 1 (TTN-AS1) was reported to be crucial modulators...

Histological Tumor Type is Associated with One-Year Cause-Specific Survival in Women with Stage III-IV Epithelial Ovarian Cancer: A Surveillance, Epidemiology, and End Results (SEER) Database Population Study, 2004-2014.

Feb 4, 2020

BACKGROUND The prognosis of epithelial ovarian cancer (EOC) remains poor. Cause-specific survival...

Poor Perfusion of Microvasculature in Peritoneal Metastases of Ovarian Cancer

Feb 4, 2020

Most women with epithelial ovarian cancer (EOC) suffer from peritoneal carcinomatosis upon first...

The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation.

Jan 31, 2020

N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal mRNAs and increasing...

Proteomic analysis of degradation ubiquitin signaling by ubiquitin occupancy changes responding to 26S proteasome inhibition.

Jan 31, 2020

Ubiquitination is a post-translational modification where ubiquitin is covalently attached to...

Genomic Signatures of Immune Activation Predict Outcome in Advanced Stages of Ovarian Cancer and Basal-Like Breast Tumors.

Jan 31, 2020

There is an unmet need for new therapies in metastatic ovarian cancer and basal-like breast cancer...

Muscle loss during primary debulking surgery and chemotherapy predicts poor survival in advanced-stage ovarian cancer.

Jan 31, 2020

Sarcopenia is commonly observed in patients with advanced-stage epithelial ovarian cancer (EOC)....

Identification three LncRNA prognostic signature of ovarian cancer based on genome-wide copy number variation.

Jan 31, 2020

Ovarian cancer is one of the most common malignant tumors of the female reproductive system, which...

Overcoming Resistance to Platinum-Based Drugs in Ovarian Cancer by Salinomycin and Its Derivatives-An In Vitro Study.

Jan 30, 2020

Polyether ionophore salinomycin (SAL) and its semi-synthetic derivatives are recognized as very...

Strong Evidences of the Ovarian Carcinoma Risk in Women after IVF Treatment

Jan 30, 2020

In-vitro fertilization (IVF) has been very popular since the birth of the first...

Should MMMT still be treated with adjuvant taxane-based combination chemotherapy?

Jan 30, 2020

Malignant mixed Mullerian tumors of endometrial (MMMT-E) and ovarian (MMMT-O) origin are...

Trabectedin (Yondelis®) as a Therapeutic Option in Gynecological Cancers: A Focus on its Mechanisms of Action, Clinical Activity, and Genomic Predictors of Drug Response.

Jan 30, 2020

The use of predictive biomarkers provides potential individualized cancer therapeutic options to...

PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin.

Jan 30, 2020

Protein arginine methyltransferase 1 (PRMT1) is overexpressed in various human cancers and linked...

Hyperthermic intraperitoneal chemotherapy for ovarian cancer: The heat is on.

Jan 23, 2020

Patients with advanced epithelial ovarian cancer have a high incidence of peritoneal disease...

Treatment of recurrent epithelial ovarian cancer.

Jan 23, 2020

The majority of patients with advanced ovarian cancer progress after first-line therapy and...

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Hematology/Oncology