Detection of BRCA1/2 Large Genomic Rearrangement including BRCA1 Promoter-Region Deletions using Next-Generation Sequencing.
Germline mutations in BRCA1 and BRCA2 (BRCA1/2) have been conventionally analyzed by Sanger...
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Hematology/Oncology
ABCG2 Overexpression Contributes to Pevonedistat Resistance.
MLN4924 (pevonedistat) is a first-in-class NEDD8-activating enzyme (NAE) inhibitor in clinical...
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Vitamin D Exposure and Ovarian Cancer Risk and Prognosis.
Given the poor prognosis of ovarian cancer and limited population-level strategies for early...
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TGF-β1 fucosylation enhances the autophagy and mitophagy via PI3K/Akt and Ras-Raf-MEK-ERK in ovarian carcinoma.
Transforming growth factor-β, a cell secretion factor of the TGF-β superfamily, is involved in the...
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The DNA cytosine deaminase APOBEC3B is a molecular determinant of platinum responsiveness in clear cell ovarian cancer.
Clear cell ovarian carcinoma (CCOC) is an aggressive disease that often demonstrates resistance to...
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The miR-34 Family and its Clinical Significance in Ovarian Cancer
The tumor suppressor miR-34 family is transcriptionally induced by p53. Clinical significance of...
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Sharing Real-World Experiences to Optimize Management of Olaparib Toxicities
Olaparib is the first poly(ADP-ribose) polymerase inhibitor approved as maintenance therapy of...
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Circular RNA PVT1 enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer.
This study aimed to investigate the influence of circular RNA PVT1 (circ-PVT1) on epithelial...
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Oral Metronomic Chemotherapy for Recurrent & Refractory Epithelial Ovarian Cancer
Advanced epithelial ovarian cancer (EOC) is associated with dismal outcome and progression-free...
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LncRNA TTN-AS1 acts as sponge for miR-15b-5p to regulate FBXW7 expression in ovarian cancer.
Emerging evidence showed that long noncoding RNA (lncRNA) plays crucial roles in regulating...
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Ubiquitin-specific protease 14 regulates ovarian cancer cisplatin-resistance by stabilizing BCL6 oncoprotein.
Ubiquitin-specific protease 14 (USP14) is one of the three proteasome-associated deubiquitinating...
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Endoplasmic Reticulum Stress Proteins in Ovarian Carcinoma
Epithelial ovarian cancer (EOC) is a leading cause of cancer-related mortality in the United...
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microRNA-141-3p-containing small extracellular vesicles derived from epithelial ovarian cancer cells promote endothelial cell angiogenesis through activating the JAK/STAT3 and NF-κB signaling pathways.
Paracrine signaling between tumor and surrounding stromal cells is critical for the maintenance of...
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Synergistic Antitumor Effects in Drug-Resistant Ovarian Cancer
Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional...
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Knockdown of enhancer of rudimentary homolog inhibits proliferation and metastasis in ovarian cancer by regulating epithelial-mesenchymal transition.
Ovarian cancer (OC) is the deadliest gynecological malignancy. The pathogenesis of molecular in...
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Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer.
Ovarian cancer has the highest mortality rate among all gynecological cancers with its pathogenic...
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Coping with Fear of Cancer Recurrence Among Ovarian Cancer Survivors
Fear of cancer recurrence (FCR) is a paramount concern among ovarian cancer survivors. Evidence...
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Long non-coding RNA TTN-AS1 promotes tumorigenesis of ovarian cancer through modulating the miR-139-5p/ROCK2 axis.
Long non-coding RNA (lncRNA) TTN antisense RNA 1 (TTN-AS1) was reported to be crucial modulators...
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Histological Tumor Type is Associated with One-Year Cause-Specific Survival in Women with Stage III-IV Epithelial Ovarian Cancer: A Surveillance, Epidemiology, and End Results (SEER) Database Population Study, 2004-2014.
BACKGROUND The prognosis of epithelial ovarian cancer (EOC) remains poor. Cause-specific survival...
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Poor Perfusion of Microvasculature in Peritoneal Metastases of Ovarian Cancer
Most women with epithelial ovarian cancer (EOC) suffer from peritoneal carcinomatosis upon first...
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