Ovarian Cancer
Feb 22, 2021
With long-term survivorship increasingly achievable among patients with cancer, many in this population face the outcomes of treatment-related late effects, explain Richard Anderson, MD, PhD, Matteo L...
Dec 15, 2020
Published research has shown that women with ovarian cancer have among the highest rates of venous thromboembolisms (VTEs) of all patients with cancer. “An estimated 5% to 25% of patients with ovari...
Dec 14, 2020
Although cannabis remains illegal in many parts of the United States, 33 states have approved medical cannabis programs as of March 2020. “With the likely expansion of medical cannabis across the US...
Aug 14, 2020
Research indicates that women with early-stage endometrial cancer who have lymphovascular space invasion on their hysterectomy specimen have more aggressive tumors that are more likely to spread to th...
May 26, 2020
ATP citrate lyase (ACLY) is an important enzyme that catalyzes the conversion of citrate to acetyl-CoA in normal cells, facilitating the fatty acid synthesis. Lipids and fatty acids were found to be ...
May 26, 2020
The mitochondrial fission protein, Dynamin related protein 1 (Drp1), and its upstream protein calcium/calmodulin-dependent protein kinase I (CaMKI) play a critical role in chemoresistance in ovarian c...
May 26, 2020
Early-stage ovarian cancer might represent an ideal disease scenario for sentinel lymph node application. Nevertheless, the published experience seems to be limited. Our objective was to assess the fe...
May 26, 2020
Epithelial ovarian cancer (EOC) is one of the leading causes of death from gynecologic cancers and peritoneal dissemination is the major cause of death in patients with EOC. Although the loss of 4.1N ...
May 26, 2020
The objective of our research was to examine the levels of circulating LOXL1-AS1 in EOC patients and to analyze its diagnostic and prognostic value.The levels of LOXL1-AS1 in 185 EOC patients and 43 h...
May 12, 2020
Epithelial ovarian cancer is a highly lethal gynecological malignancy. Accurate and cost-effective predictive tools to estimate the prognosis of patients with epithelial ovarian cancer before treatmen...
May 12, 2020
Treatment of ovarian cancer (OC) remains the biggest challenge among gynecological malignancies. Immune checkpoint blockade therapy is promising in many cancers but shows low response rates in OC beca...
May 12, 2020
The anticancer, antimicrobial and antiplasmodial activities of six gold(iii) bis(dithiolene) complexes were studied. Complexes 1-6 showed relevant anticancer properties against A2780/A2780cisR ovarian...
May 12, 2020
CCNE1 amplification is a recurrent alteration associated with unfavourable outcome in tubo-ovarian high-grade serous carcinoma (HGSC). We aimed to investigate whether immunohistochemistry (IHC) can be...
May 12, 2020
Ovarian cancer remains the leading cause of gynecologic cancer-related death among women worldwide. The dismal survival rate is partially due to recurrence after standardized debulking surgery and fir...
Apr 28, 2020
Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian ...
Apr 28, 2020
Risk-reducing salpingo-oophorectomy (RRSO) has been associated with approximately 50% breast cancer risk reduction among women with a pathogenic variant in or (), a finding that has recently been qu...
Apr 28, 2020
The novel copper complex [Cu(phen)2(salubrinal)](ClO4)2 (C0SAL) has been synthesised and characterised. Copper(ii) is coordinated by salubrinal through the thionic group, as shown by the UV-Vis, IR, E...
Apr 28, 2020
The serum marker CA 125 is still the most widely used biomarker for ovarian cancer (OC) diagnosis in gynecological and oncological setting, but its predictive role in early-stage OC is still debated. ...
Apr 28, 2020
Ovarian cancer cells shed from primary tumors can spread easily to the peritoneum via the peritoneal fluid. To allow further metastasis, the cancer cells must interact with the mesothelial cell layer,...
Apr 22, 2020
A central and unique aspect of high-grade serous ovarian carcinoma (HGSC) is the extensive transcoelomic spreading of tumor cell via the peritoneal fluid or malignant ascites. We and others identified...