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Critical Care General

The risk of transmission of the novel coronavirus (SARS-CoV-2) with human heart valve transplantation: evaluation of cardio-vascular tissues from two consecutive heart donors with asymptomatic COVID-19.

Mar 11, 2021

We report on two living donors of explanted hearts while receiving heart transplantation that tested positive for SARS-CoV-2 on the day of donation, although clinically asymptomatic. They underwent he...

Ex Vivo Normothermic Hypoxic Rat Liver Perfusion Model: An Experimental Setting for Organ Recondition and Pharmacological Intervention.

Mar 11, 2021

The gold standard for organ preservation before transplantation is static cold storage, which is unable to fully protect suboptimal livers from ischemia/reperfusion injury. An emerging alternative is ...

A Cationic Metal-Organic Framework to Scavenge Cell-Free DNA for Severe Sepsis Management.

Mar 11, 2021

Circulating cell-free DNA (cfDNA) released by damaged cells causes inflammation and has been associated with the progression of sepsis. One proposed strategy to treat sepsis is to scavenge this inflam...

Role of medical thoracoscopy in the treatment of complicated parapneumonic effusions.

Mar 11, 2021

The role of medical thoracoscopy in the treatment of pleural infections is increasingly being recognized. This study was done to assess the role of medical thoracoscopy in the management of carefully ...

A time-sensitive analysis of the prognostic utility of vasopressor dose in septic shock.

Mar 11, 2021

It is unclear whether the association between vasopressor dose and mortality is affected by duration of administration. We examined whether prognostication in septic shock is feasible through the use ...

Evaluation of Short-term Outcomes of Tracheostomy Procedures in a NICU Population With High Ventilator Settings.

Mar 11, 2021

To investigate whether tracheostomy placement in infants requiring high ventilator pressure is safe and effective.Case series with chart review.Tertiary children's hospital.Fifty ventilator-dependent ...

[The praise of uncertainty: a systematic living review to evaluate the efficacy and safety of drug treatments for patients with covid-19.]

Mar 11, 2021

SARS-CoV-2 is a coronavirus that causes a disease which can leads to a severe form of fatal pneumonia. At december 2020 in Italy, more than 2 million people have contracted the virus and 78,755 people...

Differential impacts of postoperative complications on patients' survival in completely resected non-small-cell lung cancer.

Mar 11, 2021

The aim of this study was to investigate the effects of inflammatory respiratory complications on long-term survival in patients with resected non-small cell lung cancer. We defined inflammatory respi...

Efficacy and Safety of Long-Term Antithrombotic Strategies in Patients With Chronic Coronary Syndrome: A Network Meta-analysis of Randomized Controlled Trials.

Mar 11, 2021

Background Long-term antithrombotic strategies for patients with chronic coronary syndrome with high-risk factors represent an important treatment dilemma in clinical practice. Our aim was to conduct ...

Factors associated with neurodevelopment in preterm infants with systematic inflammation.

Mar 11, 2021

Several studies have suggested that adverse neurodevelopment could be induced by systemic inflammation in preterm infants. We aimed to investigate whether preterm infants with systemic inflammation wo...

'We always find things to learn from.' Lessons from the implementation of the global maternal sepsis study on research capacity: a qualitative study.

Mar 11, 2021

Research capacity strengthening could be an indirect outcome of implementing a research project. The objective of this study was to explore the ability of the global maternal sepsis study (GLOSS), imp...

DeepAISE - An interpretable and recurrent neural survival model for early prediction of sepsis.

Mar 11, 2021

Sepsis, a dysregulated immune system response to infection, is among the leading causes of morbidity, mortality, and cost overruns in the Intensive Care Unit (ICU). Early prediction of sepsis can impr...

Complications of cranioplasty in relationship to traumatic brain injury: a systematic review and meta-analysis.

Mar 11, 2021

Despite being a common procedure, cranioplasty (CP) is associated with a variety of serious, at times lethal, complications. This study explored the relationship between the initial injury leading to ...

Long noncoding RNA NKILA transferred by astrocyte-derived extracellular vesicles protects against neuronal injury by upregulating NLRX1 through binding to mir-195 in traumatic brain injury.

Mar 11, 2021

The study aims to investigate the effects of long noncoding RNA (lncRNA) transmitted nuclear factor-κB interacting lncRNA (NKILA)-containing astrocyte-derived small extracellular vesicles (EVs) on tr...

Serum neuron-specific enolase levels associated with connectivity alterations in anterior default mode network after mild traumatic brain injury.

Mar 11, 2021

Mild traumatic brain injury (mTBI) is the most prevalent neurological insult and leads to long-lasting cognitive impairment. Neuroimaging studies have discovered abnormalities in brain network connect...

Impact of the size of non-ablated left atrial posterior wall area on outcomes after extensive encircling pulmonary vein isolation.

Mar 11, 2021

The aim of this study was to evaluate the impact of the size of the isolated surface area and non-ablated left atrial posterior area after extensive encircling pulmonary vein isolation (EEPVI) for non...

Current clinical applications of speckle tracking echocardiography for assessment of left atrial function.

Mar 11, 2021

Two-dimensional speckle tracking echocardiography (2D-STE) enables assessment of left atrial (LA) function with better reproducibility and less load dependence than those with conventional methods. Da...

Making the Case for Withholding Preoperative Prophylactic Antibiotics in Patients With Non-Severe Burns

Mar 09, 2021

Data indicate that overuse of antibiotics is a main driver of antibiotic resistance, with every exposure to antibiotics creating a selection event with each patient’s microbiome, in turn, giving ris...

Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation.

Mar 08, 2021

NOD-like receptor protein 3 (NLRP3) inflammasome is tightly related to the pathogenesis of cerebral ischemia/reperfusion (I/R) injury, and oridonin (Ori) has shown the potential to alleviate ischemia/...

Resveratrol suppresses the reprogramming of macrophages into an endotoxin-tolerant state through the activation of AMP-activated protein kinase.

Mar 08, 2021

Resveratrol has been reported to have beneficial effects on sepsis by regulating the inflammatory response. However, it remains unclear if resveratrol plays a role in the development of endotoxin tole...

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