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Critical Care General

Diffuse interstitial pneumonia-like/macrophage activation syndrome-like changes in patients with COVID-19 correlate with length of illness.

May 17, 2021

Assess the pathologic changes in the lungs of COVID-19 decedents and correlate these changes with demographic data, clinical course, therapies, and duration of illness.Lungs of 12 consecutive COVID-19...

Continuous Infusion, Therapeutic Drug Monitoring and Outpatient Parenteral Antimicrobial Therapy with Ceftazidime-Avibactam: a Retrospective Cohort Study.

May 17, 2021

Based on recent PK/PD evidence, continuous infusion (CI) of β-lactam administration is increasingly recommended for serious infections. Since 2016, the combination of ceftazidime and avibactam (CAZ/A...

Adjunctive homeopathic treatment of hospitalized COVID-19 patients (COVIHOM): A retrospective case series.

May 17, 2021

and purpose. COVID-19 is a novel viral disease causing worldwide pandemia. The aim of this study was to describe the effect of adjunctive individualized homeopathic treatment delivered to hospitalized...

Restricted antimicrobial prescribing in an area of highly prevalent antimicrobial resistance.

May 17, 2021

To assess the predictive value for infection with multidrug-resistant organisms (MDROs) of reasons for empirical prescription of restricted antibiotics (rABX), in a setting with high resistance rates....

Effects of Stricter Management Guidelines on Return-to-Competition Timeframes Following Concussion in Professional Australian Rules Football: An Exploratory Analysis.

May 17, 2021

Management of concussion remains a serious issue for professional sports, particularly with the growing knowledge on the consequences of repetitive concussion. One primary concern is the subjective as...

Ruxolitinib exerts neuroprotection via repressing ferroptosis in a mouse model of traumatic brain injury.

May 17, 2021

Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Various forms of cells death are involved in the pathological process of TBI, without exception to ferroptosis, which i...

Outcomes of Fludarabine, Melphalan and Total Body Irradiation as a Reduced Intensity Conditioning Regimen in Matched Donor Allogeneic Peripheral Blood Stem Cell Transplantation: Outcomes of Flu-Mel-TBI.

May 17, 2021

Fludarabine 30 mg/m/day x 5 and melphalan 140 mg/m x 1 (Flu-Mel140) is a commonly used RIC regimen. We hypothesized that addition of 200cGy total body irradiation (TBI) to Flu-Mel140 may improve antit...

Continuous positive airway pressure improves work of breathing in pediatric chronic heart failure.

May 17, 2021

Sleep disordered breathing (SDB) is common in adults with chronic heart failure (CHF), but its prevalence in children remains unclear. Continuous positive airway pressure (CPAP) is the treatment of SD...

Ultrasonic blood flowmeter with a novel Xero algorithm for a mechanical circulatory support system.

May 17, 2021

Mechanical circulatory support systems (MCSSs) are crucial devices for transplants in patients with heart failure. The blood flowing through the MCSS can be recirculated or even stagnated in the event...

Simplified frontal EEG in adults under veno-arterial extracorporeal membrane oxygenation.

May 17, 2021

EEG-based prognostication studies in intensive care units often rely on a standard 21-electrode montage (EEG) requiring substantial human, technical, and financial resources. We here evaluate whether ...

Intestinal amyloidosis: Clinical manifestations and diagnostic challenge.

May 13, 2021

Amyloidosis is a heterogeneous group of diseases in which the extracellular deposition of abnormal fibrillar proteins disrupts tissue structure and function. Intestinal involvement is a very rare mani...

Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p.

May 13, 2021

In recent years, increasing discovery of the extremely important regulatory effects of circular RNAs on biological development, angiogenesis, tumor genesis, and development, as well as stem cell proli...

Mortality and Morbidity of Infants Born Extremely Preterm at Tertiary Medical Centers in China From 2010 to 2019.

May 13, 2021

Extreme prematurity is associated with a substantial burden on health care systems worldwide. However, little is known about the prognosis of infants born extremely preterm in developing countries, su...

The Golden Hour: Sustainability and Clinical Outcomes of Adequate Time to Antibiotic Administration in Children with Cancer and Febrile Neutropenia in Northwestern Mexico.

May 13, 2021

Time to antibiotic administration (TTA) is a commonly used standard of care in pediatric cancer settings in high-income countries. Effective interventions to improve outcomes in cancer patients with f...

The effect of early vasopressin use on patients with septic shock: A systematic review and meta-analysis.

May 13, 2021

The effect of early vasopressin initiation on clinical outcomes in patients with septic shock is uncertain. A systematic review and meta-analysis was performed to evaluate the impact of early start of...

Inhaled bacteriophage therapy in a porcine model of pneumonia caused by Pseudomonas aeruginosa during mechanical ventilation.

May 13, 2021

Pseudomonas aeruginosa is a main cause of ventilator-associated pneumonia (VAP) with drug-resistant bacteria. Bacteriophage therapy has experienced resurgence to compensate for the limited development...

Genetic and non-genetic factors associated with health and vitality traits in beef calves.

May 13, 2021

Awareness and interest in calf health and wellbeing is intensifying, prompting change in the management and breeding decisions of producers and associated policy-makers. The objectives of the present ...

Nasopharyngeal Pneumococcal Colonization Density is Associated with Severe Pneumonia in Young Children in the Lao PDR.

May 13, 2021

No studies have explored the association between pneumococcal nasopharyngeal density and severe pneumonia using the WHO 2013 definition. In Lao People's Democratic Republic (Lao PDR), we determine the...

Coronary plaque composition influences biomechanical stress and predicts plaque rupture in a morpho-mechanic OCT analysis.

May 13, 2021

Plaque rupture occurs if stress within coronary lesions exceeds the protection exerted by the fibrous cap overlying the necrotic lipid core. However, very little is known about the biomechanical stres...

Macrophage-preferable delivery of the leucine-rich repeat domain of NLRX1 ameliorates lethal sepsis by regulating NF-κB and inflammasome signaling activation.

May 13, 2021

Sepsis is an acute systemic inflammatory disease triggered by bacterial infection leading organ dysfunctions that macrophages are responsible for major triggering of systemic inflammation. Treatment o...

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