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Critical Care General

SIRT2 inhibition exacerbates p53-mediated ferroptosis in mice following experimental traumatic brain injury.

Jun 10, 2021

Ferroptosis plays an important role in traumatic brain injury (TBI). The p53 protein is a major mediator of ferroptosis. However, the role of p53-mediated ferroptosis in TBI has not been studied. Sirt...

Metagenomic analysis of gut microbiota reveals its role in trimethylamine metabolism in heart failure.

Jun 10, 2021

We had previously reported an increase in trimethylamine N-oxide (TMAO) levels in patients with both compensated and decompensated heart failure (HF) and alteration in gut microbiota composition using...

Cerebral Structure and Function in Stroke-free Patients with Atrial Fibrillation.

Jun 10, 2021

Atrial fibrillation (AF) is associated with high risk of dementia and brain atrophy in stroke-free patients, but the mechanisms underlying this association remain unclear. We aimed to examine the brai...

COVID-19: Autopsy findings in six patients between 26 and 46 years of age.

Jun 07, 2021

Studies on the coronavirus disease 2019 (COVID-19) usually focus on middle aged and older adults. However, younger patients may present with severe COVID-19 and potentially fatal outcomes. For optimiz...

New mechanisms of ginseng saponin-mediated anti-inflammatory action via targeting canonical inflammasome signaling pathways.

Jun 07, 2021

Ginseng is an ethnopharmacological herbal plant in Asian countries, particularly in Korea, China, and Japan. Ginseng saponins, including ginsenosides, are major active components in ginseng and have b...

Vasopressor and inotrope treatment for septic shock: An umbrella review of reviews.

Jun 07, 2021

To review the characteristics, findings and quality of systematic reviews (SRs) on the effect of any vasopressor/inotrope on outcomes in adult patients with sepsis compared with either no treatment, a...

High-grade intradiverticulum bladder tumor: A case report.

Jun 07, 2021

Bladder diverticula are mucosal outpunching of the bladder without a muscle layer. It could be detected incidentally or by giving symptoms of its complications.A 59-year-old male patient presented wit...

COVID-19 patients' sera induce epithelial mesenchymal transition in cancer cells.

Jun 07, 2021

Covid-19 Pneumonia of SARS-CoV-2 pandemic infection, persists to have high disease burden especially in cancer patients. Increased inflammation and thromboembolic processes are blamed to influence can...

Use of post-mortem chest computed tomography in Covid-19 pneumonia.

Jun 07, 2021

COVID-19 is an extremely challenging disease, both from a clinical and forensic point of view, and performing autopsies of COVID-19 deceased requires adequately equipped sectorial rooms and exposes he...

MENINGO-ENCEPHALITIS IN A MIDDLE-AGED WOMAN HOSPITALIZED FOR COVID-19.

Jun 07, 2021

The aim: To pay attention of clinicians to possible lesions of the central nervous system (encephalitis) in patients with COVID-19.Case presentation: A 44-year-old woman was admitted to our clinic bec...

Cardiovascular risk prediction in type 2 diabetes before and after widespread screening: a derivation and validation study.

Jun 07, 2021

Until recently, most patients with diabetes worldwide have been diagnosed when symptomatic and have high cardiovascular risk, meaning most should be prescribed cardiovascular preventive medications. H...

Association of Initial Potassium Levels with the Type of Stroke in the Emergency Department.

Jun 03, 2021

Serum potassium levels are considered as a marker of cerebrovascular emergencies but there is less clarity on the association between initial serum potassium levels recorded on patient's arrival at th...

Emerging Concepts in Vascular Dementia: A Review.

Jun 03, 2021

Vascular dementia (VaD) is the second most common cause of dementia and a major health concern worldwide. A comprehensive review on VaD is warranted for better understanding and guidance for the pract...

Diagnosis and management of acute lower gastrointestinal bleeding: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.

Jun 03, 2021

1: ESGE recommends that the initial assessment of patients presenting with acute lower gastrointestinal bleeding should include: a history of co-morbidities and medications that promote bleeding; hemo...

Stress and the Gut-Brain Axis: Implications for Cancer, Inflammation and Sepsis.

Jun 03, 2021

The gut-brain axis has been discussed, directly or indirectly, for centuries, with the ideas of the gut affecting anything from moods to overall physiology being discussed across the centuries. With a...

BAM15, a Mitochondrial Uncoupling Agent, Attenuates Inflammation in the LPS Injection Mouse Model: An Adjunctive Anti-Inflammation on Macrophages and Hepatocytes.

Jun 03, 2021

Controlof immune responses through the immunometabolism interference is interesting for sepsis treatment. Then, expression of immunometabolism-associated genes and BAM15, a mitochondrial uncoupling ag...

Lesson learned from the 2017 measles outbreak in Italy: report from an emergency department.

Jun 03, 2021

Measles is a preventable disease still responsible for a number of outbreaks worldwide. Although most adults with measles recover uneventfully, measles-related complications may occur. However, as to ...

IL-4 protects mice against lethal influenza and Streptococcus pneumoniae co-infected pneumonia.

Jun 03, 2021

Streptococcus pneumoniae (S. pneumoniae) co-infection post influenza is a major cause of mortality characterized by uncontrolled bacteria burden and excessive immune response during influenza pandemic...

Respiratory bacterial co-infections in intensive care unit-hospitalized COVID-19 patients: Conventional culture vs BioFire FilmArray pneumonia Plus panel.

Jun 03, 2021

The prevalence and microbiology of concomitant respiratory bacterial infections in patients with SARS-CoV-2 infection are not yet fully understood. In this retrospective study, we assessed respiratory...

High-sensitivity troponin assays for early rule-out of acute myocardial infarction in people with acute chest pain: a systematic review and economic evaluation.

Jun 03, 2021

Early diagnosis of acute myocardial infarction is important, but only 20% of emergency admissions for chest pain will actually have an acute myocardial infarction. High-sensitivity cardiac troponin as...

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