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Critical Care General

Seasonal burden of severe influenza virus infection in the critically ill patients, using the Assistance Publique-HĂ´pitaux de Paris clinical data warehouse: a pilot study.

Aug 02, 2021

At the critical care level, the flu surveillance system is limited in France, with heterogeneous regional modalities of implementation.We aimed at assessing the relevance of the Assistance Publique-HĂ...

Outcomes of ICU patients with and without perceptions of excessive care: a comparison between cancer and non-cancer patients.

Aug 02, 2021

Whether Intensive Care Unit (ICU) clinicians display unconscious bias towards cancer patients is unknown. The aim of this study was to compare the outcomes of critically ill patients with and without ...

Oxidative stress following acute kidney injury causes disruption of lung cell cilia and their release into the bronchoaveolar lavage fluid and lung injury, which are exacerbated by Idh2 deletion.

Jul 29, 2021

Acute kidney injury (AKI) induces distant organ injury, which is a serious concern in patients with AKI. Recent studies have demonstrated that distant organ injury is associated with oxidative stress ...

Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury.

Jul 29, 2021

Based on the pathophysiology of acute kidney injury (AKI), it is plausible that certain early interventions by the nephrologist could influence its trajectory. In this study, we investigated the impac...

Effect of Peri-Operative Hyperoxygenation on Surgical Site Infection in Patients Undergoing Emergency Abdominal Surgery: A Randomized Controlled Trial.

Jul 29, 2021

The rationale for hyperoxygenation in controlling surgical site infection (SSI) has been described in many studies yet has not been defined clearly. Some studies in colorectal surgery have reported b...

Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.

Jul 29, 2021

Fritillariae thunbergii Bulbus (FT), knowns as "Jeolpaemo ()" in Korean traditional medicine, is a perennial plant belonging to the Liliaceae family and has been used to treat symptoms such as cough, ...

Population pharmacokinetics of continuous infusion piperacillin/tazobactam in very elderly hospitalized patients and considerations for target attainment against Enterobacterales and Pseudomonas aeruginosa.

Jul 29, 2021

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very elderly patients. The aims is to conduct a population pharmacokinetic analysis of CI piperacillin/tazoba...

A novel substrate based on electrospun polyurethane nanofibers and electrosprayed polyvinyl alcohol microparticles for recombinant human erythropoietin delivery.

Jul 29, 2021

After myocardial infarction caused by a heart attack, endothelial cells need to be preserved in order to regenerate new capillaries. Moreover, sufficient mechanical support is necessary for the infarc...

Characterization of familial hypercholesterolemia in Taiwanese ischemic stroke patients.

Jul 29, 2021

Familial hypercholesterolemia (FH) is a common genetic disorder characterized by a lifelong elevated low-density lipoprotein cholesterol (LDL-C) level. The relationship between FH and ischemic stroke ...

Unusual presentations of a severe type 2 leprosy reaction mimicking sepsis induced by helminth infection.

Jul 29, 2021

We describe an unusual case of type 2 leprosy reaction (T2R) with septic shock-like features induced by helminth infection in a 31-year-old Moluccan male patient with a history of completed treatment ...

Open-label, Multicenter Phase II Study of Combination Therapy of Imatinib Mesylate and Mycophenolate Mofetil in pediatric patients with Steroid-Refractory Sclerotic/fibrotic Type Chronic Graft-versus-host disease.

Jul 29, 2021

Steroid-refractory chronic graft-versus-host disease (cGVHD) is associated with high morbidity. To date, there is no standard therapy for patients who fail to respond to steroids.In this study, we eva...

IgM-enriched immunoglobulin in COVID-19: Case series of 15 severely ill SARS-CoV-2-infected patients.

Jul 29, 2021

The healthcare system in Iran, like most around the world, is managing thousands of patients hospitalised with COVID-19. In Iran, in-hospital mortality is in the region of 25%, rising to 50-60% in pat...

A comparison of Hyperspectral imaging with routine vascular noninvasive techniques to assess the healing prognosis in patients with diabetic foot ulcers.

Jul 29, 2021

To compare the potential healing prognosis of the different routine noninvasive techniques implemented in the International Working Group Diabetic Foot Guidelines with the novel use of hyperspectral i...

Mechanical Characterisation of the Human Dura Mater, Falx Cerebri and Superior Sagittal Sinus.

Jul 29, 2021

The cranial meninges have been shown to play a pivotal role in traumatic brain injury mechanopathology. However, while the mechanical response of the brain and its many subregions have been studied ex...

CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injury.

Jul 29, 2021

Traumatic brain injury (TBI) is a prevalent head injury worldwide which increases the risk of neurodegenerative diseases. Increased reactive oxygen species (ROS) and inflammatory chemokines after TBI ...

Mid- to late-life inflammation and risk of cardiac dysfunction, HFpEF, and HFrEF in late-life.

Jul 29, 2021

Epidemiologic data supporting the association of accumulated inflammation from mid-to late-life with late life risk of cardiac dysfunction and heart failure (HF) is limited.Among 4,011 participants in...

Comorbidity in Stroke-Survivors: Prevalence and Associations with Functional Outcomes and Health.

Jul 29, 2021

The purpose of this study was to evaluate the prevalence and impact of stroke-related comorbidity in a community-based sample of stroke survivors. We sought to find out which types of comorbidity that...

Updated Guidance on Managing C. difficile Infection

Jul 26, 2021

“While the burden of diarrhea and colitis due to C. difficile infection (CDI) has decreased slightly in the United States, it is still responsible for nearly 500,000 cases, and 70,000 recurrent case...

Endovascular aortic repair for abdominal aortic injury complicated with bowel injury due to blunt abdominal trauma: A case report.

Jul 26, 2021

Blunt abdominal aortic injury (BAAI) resulting from blunt abdominal trauma is rare; therefore, there are no standard guidelines for its treatment. Herein, we report the successful treatment of BAAI vi...

Direct in vivo reprogramming with non-viral sequential targeting nanoparticles promotes cardiac regeneration.

Jul 26, 2021

microRNA-mediated direct cardiac reprogramming, directly converts fibroblasts into induced cardiomyocyte-like cells (iCMs), which holds great promise in cardiac regeneration therapy. However, effectiv...

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