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Critical Care General

Advances in endotoxin analysis.

Jan 29, 2024

The outer membrane of gram-negative bacteria is primarily composed of lipopolysaccharide (LPS). In addition to protection, LPS defines the distinct serogroups used to identify bacteria specifically. F...

Exploration and validation of signature genes and immune associations in septic cardiomyopathy.

Jan 29, 2024

An early and accurate diagnosis of septic cardiomyopathy is vital for improving the overall prognosis of sepsis. In our research, we aimed to identify signature genes and their immune connections in s...

Risk factors and predicting nomogram for the clinical deterioration of non-severe community-acquired pneumonia.

Jan 29, 2024

Currently, there remains insufficient focus on non-severe community-acquired pneumonia (CAP) patients who are at risk of clinical deterioration, and there is also a dearth of research on the related r...

Diagnosis and management of complications following pelvic organ prolapse surgery using a synthetic mesh: French national guidelines for clinical practice.

Jan 29, 2024

Complications associated with pelvic organ prolapse (POP) surgery using a synthetic non-absorbable mesh are uncommon (<5%) but may be severe and may hugely diminish the quality of life of some wome...

Knowledge, Attitudes, Practices and Perceived Challenges for Healthcare Workers on Water-Less ICU Care at a Neonatal Intensive Care Unit in Singapore.

Jan 29, 2024

Implementation of water-less care, including removal of sinks from patient care areas, is an emerging approach to reduce water-borne infections in high-risk areas such as intensive care units (ICUs). ...

A retrospective analysis of concussion and post-concussional syndrome diagnoses in Western Australian emergency departments.

Jan 29, 2024

To determine the rate of concussion diagnoses per capita recorded in hospital emergency departments in Western Australia (WA) from 2002-2018 for ICD-10-AM concussion diagnoses S06.00-S06.05, and post-...

Firearm storage practices among military veterans in the United States: Findings from a nationally representative survey.

Jan 29, 2024

Unsafe storage of firearms is associated with heightened risk of suicide among veterans. However, contemporary population-based data on the prevalence and correlates of firearm storage practices among...

D-ribose metabolic disorder and diabetes mellitus.

Jan 29, 2024

D-ribose, an ubiquitous pentose compound found in all living cells, serves as a vital constituent of numerous essential biomolecules, including RNA, nucleotides, and riboflavin. It plays a crucial rol...

PARP-2 mediates cardiomyocyte aging and damage induced by doxorubicin through SIRT1 Inhibition.

Jan 29, 2024

Doxorubicin (DOX) is an anthracycline antibiotic used as an antitumor treatment. However, its clinical application is limited due to severe side effects such as cardiotoxicity. In recent years, numero...

Pulmonary co-infections by Pneumocystis jirovecii and Herpesviridae: a seven-year retrospective study.

Jan 22, 2024

Pneumocystis jirovecii (P. jirovecii) is an opportunistic fungus responsible for Pneumocystis pneumonia (PCP) in deeply immunocompromised patients and for pulmonary colonization in individuals with mi...

Late-onset methylmalonic acidemia and homocysteinemia (cblC disease): systematic review.

Jan 22, 2024

Combined methylmalonic acidemia and homocystinuria, cblC type is an inborn error of intracellular cobalamin metabolism and the most common one. The age of onset ranges from prenatal to adult. The dise...

Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle.

Jan 15, 2024

Angiogenesis is a complex process that involves the expansion of the pre-existing vascular plexus to enhance oxygen and nutrient delivery and is stimulated by various factors, including hypoxia. Since...

Pseudomonas fluorescens pneumonia.

Jan 15, 2024

Pseudomonas fluorescens (P. fluorescens) is not generally considered a bacterial pathogen in humans; however, multiple culture-based and culture-independent studies have identified it in the indigeno...

Who enrolls and why? Examining center-specific underlying patterns behind enrollment: a New York City-based traumatic brain injury model systems study.

Jan 15, 2024

To elucidate the sociodemographic and study factors involved in enrollment in the Traumatic Brain Injury Model System (TBIMS) database, this study examined the effect of a variety of variables on enro...

The role of cognitive reserve in traumatic brain injury: a systematic review of observational studies.

Jan 15, 2024

Evaluate the role of cognitive reserve (CR) on cognitive and physical sequelae in traumatic brain injury (TBI).A comprehensive search strategy was conducted in four databases in English and Spanish in...

Desflurane improves electrical activity of neurons and alleviates oxygen-glucose deprivation-induced neuronal injury by activating the Kcna1-dependent Kv1.1 channel.

Jan 08, 2024

Several volatile anesthetics have presented neuroprotective functions in ischemic injury. This study investigates the effect of desflurane (Des) on neurons following oxygen-glucose deprivation (OGD) c...

Value function assessment to different RL algorithms for heparin treatment policy of patients with sepsis in ICU.

Jan 08, 2024

Heparin is a critical aspect of managing sepsis after abdominal surgery, which can improve microcirculation, protect organ function, and reduce mortality. However, there is no clinical evidence to sup...

Targeted therapies of inflammatory diseases with intracellularly gelated macrophages in mice and rats.

Jan 08, 2024

Membrane-camouflaged nanomedicines often suffer from reduced efficacy caused by membrane protein disintegration and spatial disorder caused by separation and reassembly of membrane fragments during th...

Autoimmune encephalitis and paraneoplastic encephalitis: difficulties in diagnosis and management in the ICU.

Jan 08, 2024

Autoimmune encephalitis (AIE) represents a category of relatively newly described neurological disorders associated with an increasing prevalence, a significant impact on the healthcare system, and a ...

Outbreak of group B Streptococcus in a neonatal care unit confirmed by whole-genome sequencing.

Jan 08, 2024

Clusters of group B Streptococcus (GBS) infections in neonatal intensive care units (NICU) are poorly documented. We aimed to assess GBS cross-transmission during an outbreak of GBS sepsis.The study w...

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