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Critical Care General

Effects of enzyme-based removal of collagen and elastin constituents on the biaxial mechanical responses of porcine atrioventricular heart valve anterior leaflets.

Sep 06, 2021

The leaflets of the atrioventricular heart valves (AHVs) regulate the one-directional flow of blood through a subtle coordination of the extracellular matrix components of the tissue, including collag...

Interpretable prediction of 3-year all-cause mortality in patients with heart failure caused by coronary heart disease based on machine learning and SHAP.

Sep 06, 2021

This study sought to evaluate the performance of machine learning (ML) models and establish an explainable ML model with good prediction of 3-year all-cause mortality in patients with heart failure (H...

The cost of the Acute Respiratory Distress Syndrome: A systematic review.

Sep 06, 2021

The acute respiratory distress syndrome (ARDS) is an inflammatory condition of the lungs and is a common condition in adult intensive care units (ICU). The resources required and costs of care for pat...

Mental Health Neglect Among Physicians

Sep 05, 2021

Previous research has suggested high rates of suicide and depression among physicians when compared with the general public. Debilitating mental illness can critically impact physicians’ ability to ...

Conference Highlights: ERS 2021 Virtual

Sep 01, 2021

New research was presented at ERS 2021, the virtual European Respiratory Society International Congress, from September 5-8. The features below highlight some of the studies presented via the online c...

Licochalcone B attenuates neuronal injury through anti-oxidant effect and enhancement of Nrf2 pathway in MCAO rat model of stroke.

Aug 30, 2021

Investigating anti-oxidant therapies that lead to the diminution of oxidative injury is priority in clinical. We herein aimed to explore whether and how Licochalcone B (Lico B) act as an anti-oxidant ...

HepaticIschemia/Reperfusion Injuryinvolves functional tryptase/PAR-2 signaling in liver sinusoidal endothelial cell population.

Aug 30, 2021

Mast cells (MCs) are tissue-resident effector cells that could be the earliest responder to release a unique, stimulus-specific set of mediators in hepatic ischemia-reperfusion (IR) injury However, ho...

Lipopolysaccharide lipid A: A promising molecule for new immunity-based therapies and antibiotics.

Aug 30, 2021

Lipopolysaccharides (LPS) are the main components of the external leaflet of the Gram-negative outer membrane and consist of three different moieties: lipid A, core oligosaccharide, and O-polysacchari...

Simultaneous determination of 11 alkaloids in rat plasma by LC-ESI-MS/MS and a pharmacokinetic study after oral administration of total alkaloids extracted from Naucleaofficinalis.

Aug 30, 2021

Nauclea officinalis, a widely used Li medicine, has been used for the treatment of cold, fever, bronchitis, pneumonia, acute tonsillitis, and other ailments. Modern pharmacological studies have demons...

Major Adverse Renal and Cardiovascular Events following Intra-Arterial Contrast Media Administration in Hospitalized Patients with Comorbid Conditions.

Aug 30, 2021

Several clinical studies and meta-analyses have demonstrated lower incidence of adverse renal and cardiovascular outcomes associated with the use of iso-osmolar contrast media (IOCM) than low-osmolar ...

Short- and long-term outcome of patients with spontaneous echo contrast or thrombus in the left atrial appendage in the era of the direct acting anticoagulants.

Aug 30, 2021

Thrombi and spontaneous echo contrast (SEC) in the left atrial appendage (LAA) are associated with thromboembolic events and poor prognosis. There are very few data on long-term outcome, especially wi...

Effect of Continuous Electrocardiogram Monitoring on Detection of Undiagnosed Atrial Fibrillation After Hospitalization for Cardiac Surgery: A Randomized Clinical Trial.

Aug 30, 2021

Postoperative atrial fibrillation (POAF) occurring after cardiac surgery is associated with adverse outcomes. Whether POAF persists beyond discharge is not well defined.To determine whether continuous...

In Vitro and In Vivo Activity of AS101 against Carbapenem-Resistant .

Aug 30, 2021

The increasing trend of carbapenem-resistant (CRAB) worldwide has become a concern, limiting therapeutic alternatives and increasing morbidity and mortality rates. The immunomodulation agent ammonium...

Development of an Immunochromatographic Strip Using Conjugated Gold Nanoparticles for the Rapid Detection of Causing Neonatal Sepsis.

Aug 30, 2021

Neonatal sepsis is a leading cause of death among newborns and infants, especially in the developing world. The problem is compounded by the delays in pinpointing the causative agent of the infection....

Prognostic and pathogenic role of CXC Motif Ligand 16 in sepsis.

Aug 30, 2021

Chemokine CXC motif ligand 16 (CXCL16) is an important mediator that has been shown to participate in various human diseases. The role of CXCL16 in the immunopathology of sepsis remains unidentified. ...

Intranasal delivery of exosomes from human adipose derived stem cells at forty-eight hours post injury reduces motor and cognitive impairments following traumatic brain injury.

Aug 30, 2021

The neuroprotective role of human adipose-derived stems cells (hASCs) has raised great interest in regenerative medicine due to their ability to modulate their surrounding environment. Our group has d...

Long-term effects of concussion on relevancy-based modulation of somatosensory-evoked potentials.

Aug 30, 2021

The purpose of this investigation was to better understand the effects of concussions on the ability to selectively up or down-regulate incoming somatosensory information based on relevance.Median ner...

Expression of orexin-A (hypocretin-A) in the hypothalamus after traumatic brain injury: A postmortem evaluation.

Aug 30, 2021

Traumatic brain injury (TBI) is one of the leading causes of mortality and morbidity. The key component of TBI pathophysiology is traumatic axonal injury (TAI), commonly referred to as diffuse axonal ...

Calcineurin in the heart: New horizons for an old friend.

Aug 30, 2021

Calcineurin, also known as PP2B or PPP3, is a member of the PPP family of protein phosphatases that also includes PP1 and PP2A. Together these three phosphatases carryout the majority of dephosphoryla...

Antimicrobial stewardship, therapeutic drug monitoring and infection management in the ICU: results from the international A- TEAMICU survey.

Aug 30, 2021

Severe infections and multidrug-resistant pathogens are common in critically ill patients. Antimicrobial stewardship (AMS) and therapeutic drug monitoring (TDM) are contemporary tools to optimize the ...

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