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Critical Care General

IL-17 stimulates neutrophils to release S100A8/A9 to promote lung epithelial cell apoptosis in Mycoplasma pneumoniae-induced pneumonia in children.

Sep 27, 2021

Mycoplasma pneumoniae-induced pneumonia (MPP) is a common cause of community-acquired respiratory tract infections, increasing risk of morbidity and mortality, in children. However, diagnosing early-s...

An observational study of T2-weighted white matter hyperintensities on magnetic resonance imaging of the internal auditory meatus and brain: ignore or not?

Sep 27, 2021

Magnetic resonance imaging of the internal auditory meatus frequently detects incidental white matter hyperintensities. This study investigated the association between these and the risk of stroke and...

Streptolysin O concentration and activity is central to in vivo phenotype and disease outcome in Group A Streptococcus infection.

Sep 27, 2021

Group A Streptoccocus (GAS) is among the most diverse of all human pathogens, responsible for a range of clinical manifestations, from mild superficial infections such as pharyngitis to serious invasi...

Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases.

Sep 27, 2021

Sepsis is a dysregulated immune response to infection and potentially leads to life-threatening organ dysfunction, which is often seen in serious Covid-19 patients. Disulfiram (DSF), an old drug that ...

A Variable Height Microfluidic Device for Multiplexed Immunoassay Analysis of Traumatic Brain Injury Biomarkers.

Sep 27, 2021

Traumatic brain injury (TBI) is a leading cause of global morbidity and mortality, partially due to the lack of sensitive diagnostic methods and efficacious therapies. Panels of protein biomarkers hav...

Success of Thrombectomy in Management of Ischemic Stroke in Two Patients with SynCardia Total Artificial Heart in Bridge-to-Transplantation.

Sep 27, 2021

Circulatory assistance from a SynCardia Total Artificial Heart (SynCardia-TAH) is a reliable bridge-to-transplant solution for patients with end-stage biventricular heart failure. Ischemic strokes aff...

Dilated Cardiomyopathy Associated with Paraquat Herbicide Poisoning.

Sep 27, 2021

Dilated cardiomyopathy is a subset of cardiomyopathies defined by reduced ejection fraction of less than 45% and a dilated left ventricle. While dilated cardiomyopathy is common, its etiology is not a...

Variation In Pediatric Palliative

Sep 20, 2021

The primary outcome was palliative care consultation, as identified by the palliative care International Classification of Disease code. Patient characteristics and outcomes were compared between thos...

Framework For Pediatric Intensivists

Sep 20, 2021

This article clearly depicts the framework of pediatric intensivists that For families facing end-of-life decisions for their critically ill children, compassionate extubation at home is a valuable se...

Hyperoxia During Cardiopulmonary Bypass

Sep 20, 2021

It has been observed in this study that Patients undergoing cardiac surgery using cardiopulmonary bypass have variable degrees of blood oxygen tension during surgery. Hyperoxia has been associated wit...

Efficacy And Safety Of Parenteral

Sep 20, 2021

The aim of this study is to understand several adult trials that have investigated the potential benefit of high-dose vitamin C therapy in critically ill patients. In pediatric patients, little is kno...

Quality Assessment Of The Literature

Sep 20, 2021

The aim is To synthesize the literature describing quality improvement in PICUs and to appraise the quality of extant research. We searched the PubMed, Cumulative Index to Nursing and Allied Health L...

Rimonabant ameliorates hepatic ischemia/reperfusion injury in rats: Involvement of autophagy via modulating ERK- and PI3K/AKT-mTOR pathways.

Sep 20, 2021

Hepatic ischemia/reperfusion (HIR), which can result in severe liver injury and dysfunction, is usually associated with autophagy and endocannabinoid system derangements. Whether or not the modulation...

Patterns of vascular response immediately after passive mobilization in patients with sepsis: an observational transversal study.

Sep 20, 2021

Sepsis is a serious organ dysfunction leading to endothelial damage in critical patients. Physiologically, there is an augment of vascular diameter in response to increased vascular blood flow and she...

Very preterm infants admitted to a tertiary neonatal unit in central Vietnam showed poor postnatal growth.

Sep 20, 2021

We aimed to evaluate the postnatal growth of very preterm infants.This was a cross-sectional observational study of neonates born before 32 weeks of gestation and admitted to the neonatal unit at Da N...

Guideline-directed low-density lipoprotein management in high-risk ischemic stroke or transient ischemic attack admissions in China from 2015 to 2019.

Sep 20, 2021

Lowering low-density lipoprotein cholesterol (LDL-C) is crucial for secondary stroke prevention in stroke patients with preexisting cardiovascular diseases (CVD) or cerebrovascular diseases (CeVD). Ho...

Forgotten DJ stent presenting with emphysematous pyelonephritis: A life threatening complication.

Sep 20, 2021

Emphysematous pyelonephritis (EPN) is an uncommon suppurative infection of renal parenchyma and perirenal tissue characterized by production of gas within renal parenchyma, collecting system or perine...

Ceftolozane/tazobactam for refractory P. aeruginosa endocarditis: A case report and pharmacokinetic analysis.

Sep 20, 2021

We describe a case of a 48 years old male with left sided endocarditis and septic emboli secondary to a Pseudomonas aeruginosa strain that developed resistance to other β-lactam antibiotics during th...

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions.

Sep 20, 2021

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent of fibrotic tissue generation and distribution of stromal cells across different lesions in the brain and s...

Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.

Sep 20, 2021

Effective treatment for the prevention of posttraumatic epilepsy is still not available. Here, we sought to determine whether blocking receptor for advanced glycation end products (RAGE) or toll-like ...

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