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Critical Care General

Hypoxic mesenchymal stem cell-derived extracellular vesicles ameliorate renal fibrosis after ischemia-reperfusion injure by restoring CPT1A mediated fatty acid oxidation.

May 09, 2022

Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellula...

Machine learning derivation of four computable 24-h pediatric sepsis phenotypes to facilitate enrollment in early personalized anti-inflammatory clinical trials.

May 09, 2022

Thrombotic microangiopathy-induced thrombocytopenia-associated multiple organ failure and hyperinflammatory macrophage activation syndrome are important causes of late pediatric sepsis mortality that ...

The Liverpool Heart And bRain Project (L-HARP): Protocol for an Observational Cohort Study of Cardiovascular Risk and Outcomes Following Stroke.

May 09, 2022

Further research is needed to refine risk prediction models for adverse cardiovascular outcomes following stroke in contemporary clinical practice, such as incident atrial fibrillation (AF), recurrent...

Association of immediate reinsertion of new catheters with subsequent mortality among patients with suspected catheter infection: a cohort study.

May 09, 2022

Central venous catheter (CVC) insertion complications are a prevalent and important problem in the intensive care unit (ICU), and source control by immediate catheter removal is considered urgent in p...

Upper Extremity Infections in the Transplant Population.

May 09, 2022

As the duration of lifetime survival after organ transplantation continues to increase, the consequences of long-term immunosuppression, such as opportunistic and rare infections, are a high-risk real...

Prenatal and postnatal insults differentially contribute to executive function and cognition: Utilizing touchscreen technology for perinatal brain injury research.

May 09, 2022

The use of touchscreen technology to evaluate cognitive deficits in animal models has grown tremendously over the past 20 years. The touchscreen apparatus encompasses many advantages, namely a high ...

The diagnostic and prognostic value of glial fibrillary acidic protein in traumatic brain injury: a systematic review and meta-analysis.

May 09, 2022

Over the years, blood biomarkers have been extensively applied for diagnostic and prognostic assessment of traumatic brain injury (TBI). Herein, we conducted a meta-analysis to evaluate the diagnostic...

Recipient-surgeon racial concordance in orthotopic heart transplantation outcomes.

May 09, 2022

Prior studies have demonstrated deleterious outcomes for physician-patient racial discordance. We explored recipient-surgeon racial concordance and short-term postoperative survival in adults undergoi...

Practical approach to clinical controversies in glycemic control for hospitalized surgical patients.

May 02, 2022

The importance of glycemic management in surgical patient populations stems from an association between hyperglycemia and increased rates of surgical site infections, sepsis, and mortality. Various gu...

Turnbull-Cutait Abdominoperineal Pull Through Operation: the Cleveland Clinic Experience in the 21 Century.

May 02, 2022

The Turnbull Cutait pull-through procedure (TCO) restores intestinal continuity in the setting of chronic pelvic sepsis, colorectal anastomotic leak, complex pelvic fistulas, and technical challenges ...

Depression Is Associated With Myocardial Infarction Within a 2-Year Period Among Adults in China.

May 02, 2022

We examined whether baseline depression is associated with myocardial infarction (MI) within a 2-year period among middle-age and older adults in China and whether the association varies by sociodemog...

Machine learning approaches to predict the 1-year-after-initial-AMI survival of elderly patients.

May 02, 2022

While multiple randomized controlled trials (RCTs) are available, their results may not be generalizable to older, unhealthier or less-adherent patients. Observational data can be used to predict outc...

Potential application of intranasal insulin delivery for treatment of intracerebral hemorrhage: A review of the literature.

May 02, 2022

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke associated with high morbidity and mortality that is considered a medical emergency, mainly managed with adequate blood pressure contr...

Neck strength and concussion prevalence in football and rugby athletes.

May 02, 2022

To determine the maximal isometric neck strength of male and female rugby and football (soccer) athletes, and to investigate the relationship between neck strength and sport played, sex, age, anthropo...

The Effect of Cardiac Resynchronization without a Defibrillator on Morbidity and Mortality: An Individual-Patient-Data Meta-Analysis of COMPANION and CARE-HF.

May 02, 2022

Cardiac resynchronization therapy (CRT) reduces morbidity and mortality for patients with heart failure, reduced left ventricular ejection fraction, QRS duration >130 ms and in sinus rhythm.To id...

Psychiatric Outcomes in ICU Patients With Family Visitation: A Population-Based Retrospective Cohort Study.

May 02, 2022

Lack of family visitation in the ICU can have long-term consequences on patients in the ICU after discharge. The effect of family visitation on the incidence of patient psychiatric disorders is unknow...

#VisualAbstract: Fewer hospital admissions and death were seen with SARS-CoV-2 Delta (B.1.617.2) compared to Omicron (B.1.1.529) variant infections

Apr 28, 2022

1. The risk of hospitalization and death was lower among cases infected with Omicron variant compared to Delta. 2. In unvaccinated cases, prior COVID-19 infection provided moderate protection. ...

Prescription Trends for Heliox in Children with Critical Asthma

Apr 28, 2022

Children with severe asthma exacerbations necessitating admission to a pediatric intensive care unit (PICU), also known as acute asthma (CA), are given several treatments, including heliox. For a stud...

Early MRI diagnosis of Sturge Weber Syndrome type 1 in infants.

Apr 25, 2022

Patients with Sturge-Weber syndrome type 1 (SWS1) have a port-wine birthmark (PWB) as cutaneous hallmark. Up to 35% of neonates with a high risk PWB develop SWS1. Clinical manifestations are severe an...

Colocolic intussusception secondary to colonic adenocarcinoma with impending caecal perforation in an elderly patient: A rare case report.

Apr 25, 2022

Intussusception is a surgical emergency in which a part of the intestine slides into the distal adjacent part. Adult colocolic intussusception secondary to a tumoral process is a rare but serious clin...

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