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Critical Care General

Elevated procalcitonin levels in patients with acetaminophen intoxication: two case reports: A CARE-compliant article.

Feb 13, 2020

Procalcitonin (PCT) is used as a biomarker for identifying the occurrence of sepsis. Previous studies have reported high levels of PCT with acetaminophen intoxication without evidence of infection. He...

The Impact of Hyperoxia in Critically Ill Patient

Feb 13, 2020

Oxygen has long been considered a vital and potentially life-saving component of emergency care. Given this, there is widespread and liberal use of supplemental oxygen in hospitals across the United S...

Platelet CLEC-2 regulates neuroinflammation and restores blood brain barrier integrity in a mouse model of traumatic brain injury.

Feb 13, 2020

Neuroinflammation accompanied by microglial activation triggers multiple cell death after traumatic brain injury (TBI). The secondary injury caused by inflammation may persist for a long time. Recentl...

Use of high-sensitivity digital ELISA improves the diagnostic performance of circulating brain-specific proteins for detection of traumatic brain injury during triage.

Feb 13, 2020

: Historically, limited sensitivity associated with traditional immunoassay methods has prevented the use of brain-specific proteins as blood biomarkers of traumatic brain injury (TBI) during triage, ...

Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1.

Feb 13, 2020

Sterile alpha and toll/interleukin receptor (TIR) motif-containing protein 1 (SARM1) plays a pivotal role in triggering the neurodegenerative processes that underlie peripheral neuropathies, traumatic...

Effect of Diagnosed Sleep Disorders on Baseline Concussion Symptom, Cognitive, and Balance Assessments in Collegiate Athletes.

Feb 13, 2020

Symptoms, cognition, balance, and other domains are commonly assessed at baseline testing as part of comprehensive preseason evaluations among collegiate student-athletes. Although approximately 27% o...

Extracellular Vesicles from Human Cardiovascular Progenitors Trigger a Reparative Immune Response in Infarcted Hearts.

Feb 13, 2020

The cardio-protective effects of human induced pluripotent stem cell-derived cardiovascular progenitor cells (CPC) are largely mediated by the paracrine release of extracellular vesicles (EV). We aime...

Aortic blood pressure and arterial stiffness in patients with controlled resistant and non-resistant hypertension.

Feb 13, 2020

The purpose of the current study was to determine whether aortic blood pressure (BP) and arterial stiffness are greater in patients with controlled resistant hypertension (RHTN) than controlled non-re...

A continued method performance monitoring approach for the determination of pediatric renin samples - application within a European clinical trial.

Feb 13, 2020

Background Plasma renin levels were determined in the academia-driven, EU-funded "Labeling of Enalapril from Neonates up to Adolescents" (LENA) project to evaluate its role in pediatric heart failure....

Research progress on myocardial regeneration: what is new?

Feb 13, 2020

The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of lar...

Chinese herbal preparations for chronic heart failure: Study protocol for an umbrella review of systematic reviews and meta-analyses.

Feb 13, 2020

Chinese herbal preparations (CHPs) have been reported to be effective in the management of chronic heart failure (CHF); they are beneficial in improving cardiac function, reducing hospital stays and r...

Role of Injection Laryngoplasty in Preventing Post-Stroke Aspiration Pneumonia

Feb 13, 2020

Injection laryngoplasty is a common procedure for patients with vocal fold dysfunction, but the literature on its benefits has been mainly focused on those related to structural lesions or laryngeal n...

Causal relationship between neuronal activity and cerebral hemodynamics in patients with ischemic stroke.

Feb 13, 2020

Neurovascular coupling enables rapid adaptation of cerebral blood flow (CBF) to support neuronal activity. Modern techniques enable the simultaneous recording of neuronal activities and hemodynamic pa...

Successful conservative management of a spontaneous intraperitoneal rupture of bladder diverticulum in a critical patient: A case report. A CARE-compliant article.

Feb 13, 2020

A spontaneous rupture of the bladder diverticulum in an adult patient is extremely rare. The recommended treatment is surgery. However, some cases can be successfully treated with urinary catheterizat...

Ethnic Risk Factors of Haemorrhagic Transformation for Acute Ischaemic Stroke

Feb 13, 2020

To determine the risk factors related to hemorrhagic transformation in Chinese patients with acute ischemic stroke treated with intravenous thrombolysis.Studies published in different languages were r...

Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial.

Feb 13, 2020

Observational studies have suggested that accelerated surgery is associated with improved outcomes in patients with a hip fracture. The HIP ATTACK trial assessed whether accelerated surgery could redu...

Use and Trends in Unprotected Left Main Coronary Artery Percutaneous Intervention

Feb 10, 2020

To review the clinical evidence on the use of percutaneous coronary intervention (PCI) revascularization options in left main (LM) disease in comparison with coronary artery bypass graft (CABG). Coron...

Diversity of Organism-Wide and Organ-Specific Endothelial Cells.

Feb 10, 2020

Endothelial cells are of great importance in many types of diseases including the coronary artery diseases in heart and stroke in brain. In this review, we explore the heterogeneity among endothelial ...

Increased platelet activation in sleep apnea subjects with intermittent hypoxemia.

Feb 10, 2020

Obstructive sleep apnea (OSA) is independently associated with increased risk for stroke and other cardiovascular diseases. Since activated platelets play an important role in cardiovascular disease, ...

Early neutrophil-to-lymphocyte ratio is a prognostic marker in acute minor stroke or transient ischemic attack.

Feb 10, 2020

Intravenous injection of alteplase is recommended for patients with minor disabling and not non-disabling ischemic stroke symptoms within 4.5 h of ischemic stroke symptom onset. However, it is hard f...

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