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Critical Care General

Ginsenoside Rb1 exerts anti-inflammatory effects in vitro and in vivo by modulating toll-like receptor 4 dimerization and NF-kB/MAPKs signaling pathways.

Mar 09, 2020

Ginsenoside Rb1, the main active constituent of Panax ginseng, displays significant anti-inflammatory activity, although the mechanism has not been clearly unraveled. In this study, Rb1's mechanism of...

Association between prior metformin therapy and sepsis in diabetes patients: a nationwide sample cohort study.

Mar 09, 2020

There have been no large-scale studies on whether metformin therapy might have a potential benefit for lowering mortality. Thus, this study aimed to investigate the association between prior metformin...

Ability of high-resolution computed tomography to distinguish Mycoplasma pneumoniae pneumonia from other bacterial pneumonia: Significance of lateral bronchial lesions, less air bronchogram, and no peripheral predominance.

Mar 09, 2020

No study has investigated the capability of high-resolution computed tomography (HRCT) to detect a lateral bronchus abnormality, degree of air bronchogram, and distribution of affected lesions in the ...

Microbiological profile of ventilator-associated pneumonia among intensive care unit patients in tertiary Egyptian hospitals.

Mar 09, 2020

Ventilator-associated pneumonia (VAP) is one of the common serious infectious diseases encountered in the intensive care unit (ICU), which highly affects the healthcare cost and patient prognosis. VAP...

Derivation and validation of a novel severity scoring system for pneumonia at ICU admission.

Mar 09, 2020

Severity stratification scores developed in Intensive Care Units (ICUs) are used in interventional studies to identify the most critically ill. Studies that evaluate accuracy of these scores in ICU pa...

Clinical characteristics of 24 asymptomatic infections with COVID-19 screened among close contacts in Nanjing, China.

Mar 09, 2020

Previous studies have showed clinical characteristics of patients with the 2019 novel coronavirus disease (COVID-19) and the evidence of person-to-person transmission. Limited data are available for a...

Duloxetine and cardiovascular adverse events: A systematic review and meta-analysis.

Mar 09, 2020

Duloxetine has been increasingly administered, but the associated cardiovascular adverse event risk is not clearly understood. Therefore, we identified the association between duloxetine and cardiovas...

l-theanine alleviates liver and kidney dysfunction in septic rats induced by cecal ligation and puncture.

Mar 09, 2020

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response against infection that triggers systemic inflammatory response syndrome. l-theanine (LT), a glutamate d...

Osteonecrosis of the femoral head due to brucellosis: a case report.

Mar 09, 2020

Brucellosis is a zoonotic infection transmitted from infected animals to humans, osteonecrosis of the femoral head (ONFH) is a devastating disease that affects patients' life with pain, dysfunction of...

Invasive intestinal mucormycosis in a 40-year old immunocompetent patient - a rarely reported clinical phenomenon: a case report.

Mar 09, 2020

Mucormycosis is rare, life-threatening fungal infection. Frequently observed in those patients having underlying immunosuppression such as, diabetes, organ transplantation, Human immunodeficiency viru...

Appropriateness of empirical antibiotics: risk factors of adult patients with sepsis in the ICU.

Mar 09, 2020

Background The appropriateness of antibiotics is the basis for improving the survival of patients with sepsis. Objective This study aimed to determine the appropriateness of empirical antibiotics, rea...

The Association of Race/Ethnicity and Total Knee Arthroplasty Outcomes in a Universally Insured Population.

Mar 09, 2020

Prior studies have documented racial/ethnic disparities in the United States for total knee arthroplasty (TKA) outcomes. One factor cited as a potential mediator is unequal access to care. We sought t...

Elevated acute plasma miR-124-3p level relates to evolution of larger cortical lesion area after traumatic brain injury.

Mar 09, 2020

Mechanisms initiated by traumatic brain injury (TBI), leading to the development of progressive secondary injury are poorly understood. MicroRNAs (miRNAs) have a proposed role in orchestrating the pos...

Occult head injuries in infants evaluated for physical abuse.

Mar 09, 2020

Abusive head injuries in infants may be occult but clinically or forensically important. Data conflict regarding yield of neuroimaging in detecting occult head injuries in infants evaluated for physic...

Post-Concussion Syndrome and Sleep Apnea: A Retrospective Study.

Mar 09, 2020

Concussion symptoms typically resolve within 7-10 days, but 10%-25% of patients do not fully recover. They can develop post-concussion syndrome (PCS), which includes sleep abnormalities such as obstru...

Cone-Beam CT for Imaging of the Head / Brain: Development and Assessment of Scanner Prototype and Reconstruction Algorithms.

Mar 09, 2020

Our aim was to develop a high-quality, mobile cone-beam CT (CBCT) scanner for point-of-care detection and monitoring of low-contrast, soft-tissue abnormalities in the head / brain, such as acute intra...

Severe hypokalemia and rebound hyperkalemia during barbiturate coma in patients with severe traumatic brain injury.

Mar 09, 2020

To evaluate the incidence of severe potassium disturbances during barbiturate coma therapy in patients with severe traumatic brain injury (TBI), and the characteristics of these patients.The study com...

Biomarkers in atrial fibrillation and heart failure with non-reduced ejection fraction: Diagnostic application and new cut-off points.

Mar 09, 2020

Atrial fibrillation (AF) and heart failure (HF) with non-reduced left ventricle ejection fraction (LVEF) present a diagnostic overlap. In this paper, we analyze differences in biomarkers between patie...

Short-term mortality risk score for de novo acute heart failure (ESSIC-FEHF).

Mar 09, 2020

Different variables are playing a role in prognosis of acute heart failure.Our purpose was to create and validate a risk score to predict mortality in patients with a first episode of acute heart fail...

CRISPLD1: a novel conserved target in the transition to human heart failure.

Mar 09, 2020

Heart failure is a major health problem worldwide with a significant morbidity and mortality rate. Although studied extensively in animal models, data from patients at the compensated disease stage ar...

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