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Critical Care General

When Zoonotic Organisms Cross Over-Trueperella pyogenes Endocarditis Presenting as a Septic Embolic Stroke.

May 28, 2020

Infective endocarditis (IE) remains a significant cause of morbidity and mortality worldwide, with numerous pathogens as culprits. We present a case of IE that evolved to a septic embolic stroke cause...

Complex Wound Closure Following Mysterious and Vicious Animal Attack.

May 28, 2020

Animal attacks are a worrisome and dangerous entity that occur at high volumes and are evaluated frequently by ER physicians, primary care physicians, trauma teams, acute care surgeons, and plastic su...

Diagnostic Value of miR-103 in Patients with Sepsis and Noninfectious SIRS and Its Regulatory Role in LPS-Induced Inflammatory Response by Targeting TLR4.

May 28, 2020

Sepsis is a life-threatening condition and a systemic inflammatory response syndrome (SIRS) driven by infection. This study aimed at investigating the expression of microRNA-103 (miR-103) in sepsis pa...

Relationship Satisfaction and Depression after Traumatic Brain Injury: An Actor-Partner Interdependence Model of Patients and Caregivers in Mexico and Colombia.

May 28, 2020

Traumatic brain injury (TBI) represents a major public health concern, particularly in low- and middle-income countries like in Latin America. Family members are often caregivers for individuals with ...

Human adipose-derived mesenchymal stem cells for acute and sub-acute TBI.

May 28, 2020

In the U.S., approximately 1.7 million people suffer traumatic brain injury each year, with many enduring long-term consequences and significant medical and rehabilitation costs. The primary injury ca...

The Attenuation of Traumatic Brain Injury via Inhibition of Oxidative Stress and Apoptosis by Tanshinone IIA.

May 28, 2020

Traumatic brain injury (TBI) is a major source of mortality and long-term disability worldwide. The mechanisms associated with TBI development are poorly understood, and little progress has been made ...

Safety and Feasibility of Performing Fenestrated Endovascular Abdominal Aneurysm Repair Using a Portable C-arm Without Fusion Technology: A Single-Center Experience.

May 28, 2020

Objective Most centers performing fenestrated endovascular aneurysm repair (F-EVAR) use hybrid rooms with fusion technology for mapping. We present our experience of successfully performing F-EVAR usi...

Innovative Left Ventricular Assist Device in High-fidelity Patient Simulator.

May 28, 2020

Left ventricular assist devices (LVADs) are implantable mechanical devices that pump blood from the apex of the left ventricle to the aorta in order to assist the forward flow of blood; they are most ...

Characteristics of Effective Teachers of Invasive Bedside Procedures: A Multi-Institutional Qualitative Study.

May 28, 2020

Faculty supervision of invasive bedside procedures (IBPs) in the intensive care unit (ICU) may enhance procedural education and ensure patient safety. However, there is limited research on teaching ef...

Intravenous fluid therapy in the perioperative and critical care setting: Executive summary of the International Fluid Academy (IFA).

May 28, 2020

Intravenous fluid administration should be considered as any other pharmacological prescription. There are three main indications: resuscitation, replacement, and maintenance. Moreover, the impact of ...

Platelets in Thrombo-Inflammation: Concepts, Mechanisms, and Therapeutic Strategies for Ischemic Stroke.

May 28, 2020

Platelets are anucleate cells known for their essential function in hemostasis and formation of thrombi under pathologic conditions. In recent years, strong evidence emerged demonstrating the critical...

[Clinical feature changes of a COVID-19 patient from mild to critical condition and cardiopulmonary pathological results].

May 28, 2020

To analyse the clinical history, laboratory tests and pathological data of a patient who suffered from novel coronavirus pneumonia(COVID-19) and provide reference for the clinical treatment of simila...

Effect of Serum Netrin-1 Levels on Diagnosis and Prognosis in Patients Admitted to the Emergency Service for Acute Coronary Syndrome.

May 28, 2020

Background Netrin-1 is a recently discovered diagnostic biomarker that indicates atherosclerosis, angiogenesis, and ischemia-reperfusion damage. There are no human studies about Netrin-1 in acute coro...

En Bloc Celiac Axis Resection for Pancreatic Cancer: Classification of Anatomical Variants Based on Tumor Extent.

May 19, 2020

En bloc celiac axis resection (CAR) for pancreatic cancer (PC) is increasingly considered after modern neoadjuvant chemotherapy (NAC). "Appleby" and "DP-CAR" are anatomically inaccurate terms as tumor...

Interleukin-36β activates autophagy of CD4+CD25+ regulatory T cells and inhibits its immunosuppressive activity in sepsis.

May 19, 2020

CD4+CD25+ regulatory T cells (Tregs) play an essential role in sepsis-induced immunosuppression. How, the effects of interleukin (IL)-36 cytokines on CD4+CD25+ Tregs and their underlying mechanism(s) ...

Systematic Review: Models of Changes in Gene Expression of MTOR, MURF-1, and MAFBX in Rats and Mice.

May 19, 2020

Various pathologies and lifestyle factors, such as nutritional factors and physical exercises, can alter the gene expression of proteins related to synthesis and degradation.We performed a systematic ...

Estimated plasma volume status (ePVS) could be an easy-to-use clinical tool to determine the risk of sepsis or death in patients with fever.

May 19, 2020

Capillary permeability can be increased in patients with sepsis. Indirect estimation of plasma volume status (ePVS) could identify more severely ill patients with fever.1502 patients evaluated for fev...

Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice.

May 19, 2020

Interleukin-1 receptor-associated kinases (IRAKs), particularly IRAK1 and IRAK4, are important in transducing signal from Toll-like receptor 4. We interrogated if a selective inhibition of IRAK1 could...

Plasma pharmacokinetics of ceftolozane/tazobactam in pediatric patients with cystic fibrosis.

May 19, 2020

The antipseudomonal cephalosporin/β-lactamase inhibitor combination ceftolozane/tazobactam could be a potential treatment option for cystic fibrosis (CF) pulmonary exacerbations. The pharmacokinetics...

Effects of SARS-CoV-2 infection on pregnant women and their infants: A retrospective study in Wuhan, China.

May 19, 2020

The pandemic of a novel coronavirus, termed SARS-CoV-2, has created an unprecedented global health burden. To investigate the effect of the SARS-CoV-2 infection on maternal, fetal, and neonatal morb...

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