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Critical Care General

Apigenin, flavonoid component isolated from Gentiana veitchiorum flower suppresses the oxidative stress through LDLR-LCAT signaling pathway.

Jun 08, 2020

Flower of Gentiana veitchiorum has traditionally been used as an herbal medicine in Tibet for treatment of variola, respiratory infection, and pneumonia. However, the effective components contained in...

Alltest rapid lateral flow immunoassays is reliable in diagnosing SARS-CoV-2 infection from 14 days after symptom onset: A prospective single-center study.

Jun 08, 2020

SARS-CoV-2 infection diagnosis is challenging in patients from 2 to 3 weeks after the onset of symptoms, due to the low positivity rate of the PCR. Serologic tests could be complementary to PCR in the...

Long-term and Temporal Outcomes of Transcatheter Versus Surgical Aortic-valve Replacement in Severe Aortic Stenosis: A Meta-analysis.

Jun 08, 2020

To determine the 5-year and temporal performance of TAVR versus SAVR.TAVR has become a valuable treatment for severe aortic stenosis but the long-term safety and efficacy remain unclear.Databases were...

Continuing versus suspending angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: Impact on adverse outcomes in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)--The BRACE CORONA Trial.

Jun 08, 2020

Angiotensin-converting enzyme-2 (ACE2) expression may increase due to upregulation in patients using angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). Because r...

Infections of Deep Hand and Wrist Compartments.

Jun 08, 2020

The human hand is the most exposed part of the body to highest risk for injuries, loss of the skin integrity, and to the inoculation of bacteria, most commonly Staphylococcus aureus, Streptococcus β-...

Delta neutrophil index as a predictive and prognostic factor for Candidemia patients: a matched case-control study.

Jun 08, 2020

Delayed antifungal therapy for candidemia leads to increased mortality. Differentiating bacterial infection from candidemia in systemic inflammatory response syndrome (SIRS) patients is complex and di...

Biomarkers of sepsis: time for a reappraisal.

Jun 08, 2020

Sepsis biomarkers can have important diagnostic, therapeutic, and prognostic functions. In a previous review, we identified 3370 references reporting on 178 different biomarkers related to sepsis. In ...

Traumatic brain injury and hippocampal neurogenesis: Functional implications.

Jun 08, 2020

In the adult brain, self-renewing radial-glia like (RGL) progenitor cells have been shown to reside in the subventricular zone and the subgranular zone of the hippocampus. A large body of evidence sho...

A case series of post-transplant cyclophosphamide in unrelated donor hematopoietic transplantation for aplastic anemia.

Jun 08, 2020

Patients with severe aplastic anemia who fail immunosuppressive therapy have a dismal prognosis. Hematopoietic stem cell transplantation (HSCT) from an unrelated donor (URD) is one of the most effecti...

Hydrogen and therapeutic gases for neonatal hypoxic-ischemic encephalopathy: potential neuroprotective adjuncts in translational research.

Jun 08, 2020

Numerous studies have examined the potential use of therapeutic gases for the treatment of various neurological disorders. Hydrogen gas, a promising neuroprotective agent, has been a focus of study du...

Sudden Cardiac Arrest with Shockable Rhythm in Patients with Heart Failure.

Jun 08, 2020

Patients with shockable sudden cardiac arrest (SCA, ventricular fibrillation/tachycardia), have significantly better resuscitation outcomes than those with non-shockable rhythms (pulseless electrical ...

What would Sérgio Ferreira say to your physician in this war against COVID-19: How about kallikrein/kinin system?

Jun 08, 2020

Coronavirus disease 2019 (COVID-19) is an infectious disease with fast spreading all over the world caused by the SARS-CoV-2 virus which can culminate in a severe acute respiratory syndrome by the inj...

Assessment of acute treatment of hypertension in ischemic stroke patients.

Jun 08, 2020

Stroke, the most common neurologic disorder and the major cause of disability and death after heart disease causing 11.8% of the total deaths worldwide, is defined as a rapidly developing clinical sig...

Pneumonia risk and its associated factors in Parkinson's disease: A National Database Study.

Jun 08, 2020

Despite pneumonia being an emerging burden on Parkinson's disease patients, there is essentially nothing known on whether they are at an increased risk of pneumonia occurrence and their associated fac...

ICUs Become A ‘Delirium Factory’ For COVID Patients

Jun 05, 2020

Doctors are fighting not only to save lives from COVID-19, but also to protect patients’ brains. Although COVID-19 is best known for damaging the lungs, it also increases the risk of life-threat...

Randomized trial of argatroban plus recombinant tissue-type plasminogen activator for acute ischemic stroke (ARAIS): Rationale and design.

Jun 04, 2020

Previous studies have implied the efficacy and safety of argatroban plus recombinant tissue-type plasminogen activator (r-tPA) in patients with acute ischemic stroke. Further trials are needed to esta...

Effects of a single dose of vitamin D in septic children: a randomized, double-blinded, controlled trial.

Jun 04, 2020

To assess the effects of a single dose of vitamin D on 25-hydroxyvitamin D (25OHD) levels and clinical outcomes in children with vitamin D deficiency (VDD) and sepsis.In this randomized, controlled tr...

The development an artificial intelligence algorithm for early sepsis diagnosis in the intensive care unit.

Jun 04, 2020

Severe sepsis and septic shock are still the leading causes of death in Intensive Care Units (ICUs), and timely diagnosis is crucial for treatment outcomes. The progression of electronic medical recor...

Diagnostic impact of bedside chest X-ray features of 2019 novel coronavirus in the routine admission at the emergency department: case series from Lombardy region.

Jun 04, 2020

To evaluate the diagnostic accuracy and the imaging features of routine admission chest X-ray in patients suspected for novel Coronavirus 2019 (SARS-CoV-2) infection.We retrospectively evaluated clini...

Epidemiological and clinical features of 200 hospitalized patients with corona virus disease 2019 outside Wuhan, China: A descriptive study.

Jun 04, 2020

The recent outbreak of coronavirus disease 2019 (COVID-19) has spread worldwide, with especially severe epidemics occurring in cities across China.To report the epidemiological and clinical futures of...

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