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Critical Care General

Cardiac Sarcoidosis.

Jun 29, 2020

Approximately 5% of patients with sarcoidosis will have cardiac involvement presenting with one or more of ventricular arrhythmias, conduction abnormalities, and heart failure. It is estimated that a...

Cardiac Surgery 2019 Reviewed.

Jun 29, 2020

For the year 2019, almost 25,000 published references can be found in PubMed when entering the search term "cardiac surgery." We used the Preferred Reporting Items for Systematic Reviews and Meta-Anal...

Time trends and patient selection in the use of continuous ECG for detecting atrial fibrillation after stroke: a nationwide cohort study.

Jun 29, 2020

Clinical use of continuous electrocardiogram (cECG) for detecting atrial fibrillation (AF) after stroke is unclear. In a Danish nationwide cohort we described post-stroke time trends in outpatient cEC...

MicroRNAs in the regulation of cellular redox status and its implications in myocardial ischemia-reperfusion injury.

Jun 29, 2020

MicroRNAs (miRNAs) are small RNAs that do not encode for proteins and play key roles in the regulation of gene expression. miRNAs are involved in a comprehensive range of biological processes such as ...

[Prevalence and features of geriatric syndromes treatment in old patients (clinical and epidemiological study).]

Jun 29, 2020

We studied the prevalence of chronic non-communicable diseases (CND) in elderly and senile patients in conjunction with the syndrome of senile asthenia, the prevalence of sarcopenia depending on gende...

Understanding the Association of Dysanapsis With COPD Among Older Adults

Jun 27, 2020

Smoking tobacco is the best-known risk factor for COPD risk factor, but recent data from a multitude of population-based observational studies show that only a minority of lifelong smokers develop COP...

The treament of hyperglycemia in acute ischemic stroke with incretin-based drugs.

Jun 25, 2020

Stroke is a major cause of mortality and morbidity worldwide. Considerable experimental and clinical evidence suggests that both diabetes mellitus (DM) and post-stroke hyperglycemia are associated wit...

Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: two case reports.

Jun 25, 2020

To determine whether hyperbaric oxygen (HBO2) therapy be effective to improve hypoxemia for severe COVID-19 pneumonia patients.Two male patients ages 57 and 64 years old were treated. Each met at leas...

Alveolar macrophage dysfunction and cytokine storm in the pathogenesis of two severe COVID-19 patients.

Jun 25, 2020

The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a serious of clinical symptoms and severe illness, including acute respiratory distress syndrome (ARDS) and fatal ...

Compassionate Use of Tocilizumab for Treatment of SARS-CoV-2 Pneumonia.

Jun 25, 2020

Preliminary data from SARS-CoV-2 pneumonia patients indicate that a cytokine storm may increase morbidity and mortality. Tocilizumab (anti-IL-6R) is FDA-approved for treatment of cytokine storm associ...

Efficacy of Clopidogrel for Prevention of Stroke Based on Allele Status in the POINT Trial.

Jun 25, 2020

Clopidogrel is an antiplatelet drug that is metabolized to its active form by the CYP2C19 enzyme. The CHANCE trial (Clopidogrel in High-Risk Patients With Acute Nondisabling Cerebrovascular Events) fo...

Sensitivity and Specificity of Bedside Qualitative Troponin I Test Kit as Compared with the Standardized Quantitative Lab Test for Troponin I.

Jun 25, 2020

Background and objective Myocardial infarction (MI) is the leading cause of mortality and morbidity worldwide. Early diagnosis of MI remains the mainstay of prompt treatment. Thus, the shorter the doo...

Severe COVID-19: A Review of Recent Progress With a Look Toward the Future.

Jun 25, 2020

The novel coronavirus disease 2019 (COVID-19) is an acute infectious disease caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Currently, the World Health Organiza...

Role of different Th17 and Treg downstream signalling pathways in the pathogenesis of Staphylococcus aureus infection induced septic arthritis in mice.

Jun 25, 2020

Septic arthritis is a condition of bone disorder caused predominantly by Staphylococcus aureus. Following the bacterial entry activated immune cells specially macrophages and dendritic cells release p...

Bioinformatics-Based Study to Investigate Potential Differentially Expressed Genes and miRNAs in Pediatric Sepsis.

Jun 25, 2020

BACKGROUND Sepsis is an extremely common health issue with a considerable mortality rate in children. Our understanding about the pathogenic mechanisms of sepsis is limited. The aim of this study was ...

Capsaicin-sensitive fibers mediate periorbital allodynia and activation of inflammatory cells after traumatic brain injury in rats: Involvement of TRPV1 channels in post-traumatic headache.

Jun 25, 2020

Post-traumatic headache (PTH) is a condition that frequently affects individuals after traumatic brain injury (TBI). Inflammation is one of the major causes of this disability. However, little is know...

Western diet aggravates neuronal insult in post-traumatic brain injury: Proposed pathways for interplay.

Jun 25, 2020

Traumatic brain injury (TBI) is a global health burden and a major cause of disability and mortality. An early cascade of physical and structural damaging events starts immediately post-TBI. This prim...

Lower Socioeconomic Status and Co-morbid Conditions are Associated with Reduced CPAP Adherence use Among Older Adult Medicare Beneficiaries with Obstructive Sleep Apnea.

Jun 25, 2020

To examine rates of adherence to continuous positive airway pressure (CPAP) therapy among a representative sample of older adult Medicare beneficiaries with obstructive sleep apnea (OSA), and to ident...

CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy.

Jun 25, 2020

Mutations in the CFTR gene cause cystic fibrosis (CF) with myocardial dysfunction. However, it remains unknown whether CF-related heart disease is a secondary effect of pulmonary disease, or an intrin...

Risk of readmission after heart failure hospitalization in older adults with congenital heart disease.

Jun 25, 2020

Hospital readmissions are common in adults with congenital heart disease (CHD) with heart failure (HF). We sought to examine the temporal risk of readmissions, the prompting diagnoses and their determ...

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