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Critical Care General

Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study.

Jul 27, 2020

Large-scale studies are required to better characterise traumatic brain injury (TBI) and to identify the most effective treatment approaches for TBI. However, evidence is scarce and mostly originates ...

Effect of Cognitive and Physical Rest on Persistent Post-Concussive Symptoms Following a Pediatric Head Injury.

Jul 27, 2020

To evaluate the effect of cognitive and physical rest on persistent post-concussive symptoms (PPCS) in a pediatric population.A prospective cohort study of 5-18-year-olds diagnosed with an acute concu...

Lasting consequences of concussion on the aging brain: findings from the Baltimore Longitudinal Study of Aging.

Jul 27, 2020

Studies suggest that concussions may be related to increased risk of neurodegenerative diseases, such as Chronic Traumatic Encephalopathy and Alzheimer's Disease. Most neuroimaging studies show effect...

Clinical Scenario and Long-term Outcome of Childhood Takayasu Arteritis Undergoing 121 Endovascular Interventions: The Largest Cohort over a 15-year Period.

Jul 27, 2020

Evidence-based studies on endovascular approaches for childhood Takayasu arteritis(c-TA) are limited. This study presents the largest real-world scenario up-to-date for c-TA patients undergoing interv...

Population Pharmacokinetics of Candesartan in Patients with Chronic Heart Failure.

Jul 27, 2020

Heart failure (HF) causes pathological changes in multiple organs, thus affecting the pharmacokinetics of drugs. The aim of this study was to investigate the pharmacokinetics of candesartan in HF pati...

Management and prevention of anemia (acute bleeding excluded) in adult critical care patients.

Jul 27, 2020

Anemia is very common in critical care patients, on admission (affecting about two-thirds of patients), but also during and after their stay, due to repeated blood loss, the effects of inflammation on...

Association of baseline kidney disease with outcomes of transcatheter mitral valve repair by MitraClip.

Jul 27, 2020

This study sought to determine the impact of baseline chronic kidney disease (CKD) on in-hospital outcomes of transcatheter mitral valve repair with MitraClip (MC).MC is now an established treatment i...

Brain Imaging Signs and Health-Related Quality of Life after Acute Ischemic Stroke: Analysis of ENCHANTED Alteplase Dose Arm.

Jul 27, 2020

The influence of specific brain lesions on health-related quality of life (HRQoL) after acute ischemic stroke (AIS) is uncertain. We aimed to identify imaging predictors of poor HRQoL in alteplase-tre...

Less invasive treatment for broad ligament hernia: A case report.

Jul 23, 2020

Among diseases that cause small bowel obstruction, internal hernia may result in severe outcomes. Therefore, emergency laparotomy has been often performed, but it may be invasive. We experienced a cas...

RNA-seq analysis of the key long noncoding RNAs and mRNAs related to cognitive impairment after cardiac arrest and cardiopulmonary resuscitation.

Jul 23, 2020

Cardiac arrest (CA) is the leading cause of death around the world. Survivors after CA and cardiopulmonary resuscitation (CPR) develop moderate to severe cognitive impairment up to 60% at 3 months. Ac...

The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice.

Jul 23, 2020

Exaggerated release of proinflammatory mediators during sepsis contributes to inadequate vasodilatation and depressed myocardial contractility, which lead to development of shock and circulatory colla...

Is Lumbar Puncture Avoidable in Low-Risk Neonates with Suspected Sepsis?

Jul 23, 2020

 Performing lumbar punctures (LP) in all clinically suspected neonatal sepsis, as per current recommendations, results in many "negative" LPs. LPs are not without their own risks. With the intention...

Cancer and Pregnancy: National Trends.

Jul 23, 2020

 Cancer and pregnancy are likely increasing; however, updated estimates are needed to optimally address the unique needs of this patient population. The study aims to estimate the prevalence of canc...

Radiological Findings of COVID-19 in Children: A Systematic Review and Meta-Analysis.

Jul 23, 2020

The majority of the children with SARS-CoV-2 infection present with respiratory symptoms, hence various chest imaging modalities have been used in the management. Knowledge about the radiological find...

Coumaric acid analogues inhibit growth and melanin biosynthesis in Cryptococcus neoformans and potentialize amphotericin B antifungal activity.

Jul 23, 2020

Fungal infections are on the rise, since the imunocompromised population is increasing due to AIDS/HIV, organ transplant and chemotherapy. Many environmental and pathogenic fungi are able to accomplis...

Effect of depression on health behavior among myocardial infarction survivors in the United States.

Jul 23, 2020

The purpose of this study was to evaluate the effect of depression on health behavior among myocardial infarction (MI) survivors.This retrospective, cross-sectional study used publicly available 2015 ...

Best-Worst Scaling Study to Identify Complications Patients Want to Be Informed About Prior to Abdominal Aortic Aneurysm Surgery.

Jul 23, 2020

Surgeons must discuss the most severe surgical complications with their patients while making a treatment decision. However, it is unclear which complications patients deem most severe. This study aim...

Prognostic significance of pre-procedural prognostic nutritional index in patients with carotid artery stenting.

Jul 23, 2020

Inflammation and malnutrition play a critical role in the outcomes of patients undergoing carotid artery stenting (CAS). Prognostic nutritional index (PNI) is commonly utilized to evaluate the peri-op...

Serum level of soluble CD14 subtype predicts long-term prognosis in sepsis patients with cardiac dysfunction.

Jul 23, 2020

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and some sepsis patients will develop cardiac dysfunction. Sepsis-induced cardiac dysfunc...

The protective effect of vitexinin septic encephalopathy by reducing leukocyte-endothelial adhesion and inflammatory response.

Jul 23, 2020

Despite advances in therapeutic strategies and critical care management, septic encephalopathy (SE) is still a leading cause of infection-associated death in intensive care units (ICUs). Vitexin, a fl...

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