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Critical Care General

Evaluation of the Initiation Timing of Hydrocortisone in Adult Patients With Septic Shock.

Sep 07, 2020

Clinical studies evaluating the use of hydrocortisone in patients with septic shock are heterogeneous in design with conflicting results. The appropriate time in which to initiate hydrocortisone after...

Effects of dietary fern (Adiantum capillus-veneris) leaves powder on serum and mucus antioxidant defence, immunological responses, antimicrobial activity and growth performance of common carp (Cyprinus carpio) juveniles.

Sep 07, 2020

A 56-day research was performed to examine the influence of graded levels (0 (control), 0.5, 1 and 2%) of Fern (Adiantum capillus-veneris) leaves powder (FLP) in diet on immune competence and growth o...

Rectal screening displays high negative predictive value for bloodstream infections with (ESBL-producing) gram negative bacteria in neonates with suspected sepsis in a low-resource setting neonatal care unit.

Sep 07, 2020

We analyzed the concordance of rectal swab isolates and blood culture for gram negative bacteria (GNB) isolates in neonates with suspicion of neonatal sepsis admitted to a neonatal care unit in Haiti....

Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway.

Sep 07, 2020

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has extensively and rapidly spread in the world, causing an outbreak of acute infectious pneumonia. However, no specific antiviral drugs or...

Clinical significance of high on-treatment platelet reactivity in patients with prolonged clopidogrel therapy.

Sep 07, 2020

Prolonged dual antiplatelet therapy (DAPT) with aspirin and clopidogrel beyond 1 year has shown to reduce ischemic events at the expense of increased bleeding; however, limited data are available on t...

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition.

Sep 07, 2020

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke, renal failure, myocardial infarction, thrombo...

Maternal and neonatal outcomes in COVID-19 infected pregnancies: a prospective cohort study.

Sep 07, 2020

Despite the large number of pregnant women with the coronavirus disease 2019 (COVID-19), there is not enough analytical study to compare maternal and fetal consequences of COVID-19 infected with non-i...

Evaluating the Timeliness and Specificity of CD69, CD64 and CD25 as Biomarkers of Sepsis in MICE.

Sep 07, 2020

Sepsis occurs when an infection induces a dysregulated immune response, and is most commonly bacterial in origin. This condition requires rapid treatment for successful patient outcomes. However, the ...

Interferon-gamma increases monocyte PD-L1 but does not diminish T-cell activation.

Sep 07, 2020

Immune dysfunction can occur during sepsis or following major trauma. Decreased monocyte HLA-DR expression and cytokine responses are associated with mortality. Recent studies have shown that adaptive...

Quantifying the expense of deferring surgical stabilization of rib fractures: operative management of rib fractures is associated with significantly lower charges.

Sep 07, 2020

Surgical stabilization of rib fractures (SSRF) remains a relatively controversial operation, which is often deferred due to concern about expense. The objective of this study was to determine the char...

GAS5 which is regulated by Lhx8 promotes the recovery of learning and memory in rats with cholinergic nerve injury.

Sep 07, 2020

Damage to the cholinergic system in central nervous system injuries such as traumatic brain injury (TBI) and neurodegenerative diseases leads to impaired learning and cognition. Neural stem cells (NSC...

Persistent Pain, Physical Dysfunction and Decreased Quality of Life after Combat Extremity Vascular Trauma.

Sep 07, 2020

Combat-related extremity vascular injuries (EVI) have long-lasting impact on Iraq/Afghanistan Veterans. The purpose of this study is to describe long-term functional outcomes in Veterans with EVI usin...

Adaptive immune disorders in hypertension and heart failure: focusing on T-cell subset activation and clinical implications.

Sep 07, 2020

: Hypertension is a growing health concern worldwide. Established hypertension is a causative factor of heart failure, which is characterized by increased vascular resistance and intractable uncontrol...

Considerations for long-term dialysis access in patients with left ventricular assist devices.

Sep 07, 2020

Renal dysfunction, requiring renal replacement therapy (RRT) is commonly encountered in patients with left ventricular assist devices (LVAD). Continuous flow LVAD (CFLVAD) is the most widely used devi...

Uric Acid Is a Biomarker of Oxidative Stress in the Failing Heart: Lessons Learned from Trials With Allopurinol and SGLT2 Inhibitors.

Sep 07, 2020

Hyperuricemia increases the risk of heart failure, and higher levels of serum uric acid are seen in patients who have worse ventricular function, functional capacity and prognosis. Heart failure is al...

Inpatient Palliative Care Use in Patients With Pulmonary Arterial Hypertension: Temporal Trends, Predictors, and Outcomes.

Sep 07, 2020

Pulmonary arterial hypertension (PAH) is a progressive disease associated with significant morbidity and mortality. Despite the negative impact of PAH on quality of life and survival, data on use of s...

Angiotensin II Infusion for Shock: A Multicenter Study of Post-Marketing Use.

Sep 07, 2020

Vasodilatory shock refractory to catecholamine vasopressors and arginine vasopressin is highly morbid and responsible for significant mortality. Synthetic angiotensin II is a potent vasoconstrictor wh...

microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation.

Sep 07, 2020

Ischemic stroke is one of the leading causes of death globally, and inflammation is considered as a vital contributor to the pathophysiology of ischemic stroke. Recently, microRNA-421-3p-derived macro...

Effects of tamoxifen and aromatase inhibitors on the risk of acute coronary syndrome in elderly breast cancer patients: An analysis of nationwide data.

Sep 07, 2020

Aromatase inhibitors (AIs) are the preferred endocrine treatment for postmenopausal hormonal receptor-positive breast cancer. However, there is controversy on the long-term cardiovascular and cerebrov...

Spinal neurovascular complications with anterior thoracolumbar spine surgery: a systematic review and review of thoracolumbar vascular anatomy.

Sep 03, 2020

Spinal cord infarction due to interruption of the spinal vascular supply during anterior thoracolumbar surgery is a rare but devastating complication. Here, the authors sought to summarize the data on...

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