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Critical Care General

COVID-19 hits a trial: Arguments against hastily deviating from the plan.

Sep 24, 2020

The COVID-19 pandemic has substantially impacted the conduct of clinical trials. While initially preparing for a period of time, where it would likely be impossible to supervise trials in the usual wa...

Congestive heart failure treated with peritoneal dialysis or hemodialysis: typical patient profile and outcomes in real-world setting.

Sep 24, 2020

Peritoneal dialysis (PD) is increasingly used for the long-term management of hypervolemic refractory congestive heart failure (CHF) patients, in particular when complicated by renal insufficiency. Wh...

"A National Survey of Burnout and Depression Among Fellows Training in Pulmonary and Critical Care Medicine: A Special Report by the APCCMPD.

Sep 24, 2020

The prevalence of burnout and depressive symptoms is high among physician trainees.What is the burden of burnout and depressive symptoms among fellows training in pulmonary and critical care medicine ...

Transient ischemic attack without self-Awareness of symptoms witnessed by bystanders: analysis of the PROMISE-TIA registry.

Sep 24, 2020

Transient ischemic attack (TIA) can occur without self-awareness of symptoms. We aimed to investigate characteristics of patients with tissue-based diagnosis of TIA but having no self-awareness of the...

Stroke Units could be a valid alternative to Intensive Care Units for low-grade aneurysmal subarachnoid haemorrhage patients.

Sep 24, 2020

According to current guidelines, aneurysmal subarachnoid haemorrhage (aSAH) patients are mostly managed in intensive care units (ICU) regardless of baseline severity. We assessed the prognostic and ec...

Circadian influence on the microbiome improves heart failure outcomes.

Sep 24, 2020

Myocardial infarction (MI) leading to heart failure (HF) is a major cause of death worldwide. Previous studies revealed that the circadian system markedly impacts cardiac repair post-MI, and that ligh...

Acute abdomen in adult revealing unusual complicated epiploic appendagitis: A case report.

Sep 21, 2020

Epiploic appendagitis is a torsion of fatty appendages of ligamentum trees (1), it's a rare cause of abdominal pain that usually manifests by right or left iliac fossa pain, reminding of appendicitis,...

Nrf2-regulated redox signaling in brain endothelial cells adapted to physiological oxygen levels: Consequences for sulforaphane mediated protection against hypoxia-reoxygenation.

Sep 21, 2020

Ischemic stroke is associated with a surge in reactive oxygen species generation during reperfusion. The narrow therapeutic window for the delivery of intravenous thrombolysis and endovascular thrombe...

Differences in monocyte subsets are associated with short-term survival in patients with septic shock.

Sep 21, 2020

Sepsis is characterized by dynamic changes of the immune system resulting in deregulated inflammation and failure of homoeostasis and can escalate to septic shock. Circulating monocytes and other inna...

Impact of choledochotomy techniques during laparoscopic CBD exploration on short- and long-term clinical outcomes: time to change concepts A retrospective cohort study.

Sep 21, 2020

complications after laparoscopic common bile duct exploration (LCBDE) regarding choledochotomy techniques have not been adequately studied in the literature. Therefore, this study aimed to retrospecti...

Core-to-skin temperature gradient measured by thermography predicts day-8 mortality in septic shock: A prospective observational study.

Sep 21, 2020

Septic shock is associated with altered peripheral perfusion. Core-to-skin temperature gradient depends on skin perfusion and microcirculatory function. We hypothesized that a high core-to-skin temper...

Re-biopsy after first line treatment in advanced NSCLC can reveal changes in PD-L1 expression.

Sep 21, 2020

Re-biopsy in progressive advanced Non-Small-Cell Lung Cancer (NSCLC) after first line treatment may reveal information about evolving tumor biology during treatment. Our study aims to investigate the ...

Immune-related adverse events on body CT in patients with small-cell lung cancer treated with immune-checkpoint inhibitors.

Sep 21, 2020

Investigate the incidence and imaging characteristics of radiologically-evident immune-related adverse events (irAEs) on body CT in patients with small-cell lung cancer (SCLC) treated with immune-chec...

Hypocapnia, ischemic lesions, and outcomes after intracerebral hemorrhage.

Sep 21, 2020

An association between spontaneous hyperventilation, delayed cerebral ischemia, and poor clinical outcomes has been reported in subarachnoid hemorrhage. We evaluated the relationship between early pCO...

Adherence to study drug in a stroke prevention trial"?>.

Sep 21, 2020

Standards for reporting and analyzing adherence to medical therapy have recently improved due to international consensus efforts. If applied to clinical trial research in patients with stroke, these i...

Premature permanent discontinuation of apixaban or warfarin in patients with atrial fibrillation.

Sep 21, 2020

The ARISTOTLE (Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation) trial randomised patients with atrial fibrillation at risk of stroke to apixaban or warfarin. We...

Cardiovascular Complications Associated with COVID-19 and Potential Therapeutic~Strategies.

Sep 21, 2020

The outbreak of coronavirus disease 2019 (COVID-19), an infectious disease with severe acute respiratory syndrome, has now become a worldwide pandemic. Despite the respiratory complication, COVID-19 i...

[Management of late onset septic complications after IPOM implantation: case series from a hernia center].

Sep 21, 2020

The intraperitoneal onlay mesh (IPOM) is for many surgeons a pragmatic solution for the operative treatment of extensive and complex abdominal wall hernias. A few years after mesh implantation we ar...

Temperature Trajectory Subphenotypes Correlate With Immune Responses in Patients With Sepsis.

Sep 21, 2020

We recently found that distinct body temperature trajectories of infected patients correlated with survival. Understanding the relationship between the temperature trajectories and the host immune res...

Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010-2019.

Sep 21, 2020

Despite the high prevalence of Mycoplasma pneumoniae infections, reports on severe life-threatening M. pneumoniae pneumonia (MPP) in children are limited.We retrospectively enrolled pediatric patients...

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