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Critical Care General

The impact of dabigatran treatment on sinusoidal protection against hepatic ischemia-reperfusion injury in mice.

Oct 29, 2020

Thrombin is a key player in the coagulation cascade, and it is attracting much attention as a promotor of cellular injured signaling. In ischemia-reperfusion injury (IRI), which is a severe complicati...

Degenerative Cervical Myelopathy: Pathophysiology and Current Treatment Strategies.

Oct 29, 2020

Chronic compression or ischemia of the spinal cord in the cervical spine causes a clinical syndrome known as cervical myelopathy. Recently, a new term "degenerative cervical myelopathy (DCM)" was intr...

Preclinical Testing of Viral Therapeutic Efficacy in Pristane-Induced Lupus Nephritis and Diffuse Alveolar Hemorrhage Mouse Models.

Oct 29, 2020

Systemic lupus erythematosus (SLE) is a multifactorial and heterogeneous autoimmune disease involving multiple organ systems and tissues. Lupus nephritis occurs in approximately 60% of patients with S...

Pre-exposure to mechanical ventilation and endotoxemia increases Pseudomonas aeruginosa growth in lung tissue during experimental porcine pneumonia.

Oct 29, 2020

Immune system suppression during critical care contributes to the risk of acquired bacterial infections with Pseudomonas (P.) aeruginosa. Repeated exposure to endotoxin can attenuate systemic inflamma...

Swallowing evaluation by the Kuchikara Taberu Balance Chart and videoendscopic examination reveals that respiratory conditions, chewing, and position are strongly related to dysphagia.

Oct 29, 2020

This study focused on the Kuchikara Taberu Balance Chart (KTBC) as a tool for swallowing function evaluation. To clarify the relationship between videoendoscopic (VE) examination of swallowing functio...

The Liver in COVID-19-Related Death: Protagonist or Innocent Bystander?

Oct 29, 2020

The coronavirus disease 2019 (COVID-19) infection, caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), involves several organs through participation of angiotensin-conversion enzy...

COVID-19 pandemic and STEMI: pathway activation and outcomes from the pan-London heart attack group.

Oct 29, 2020

To understand the impact of COVID-19 on delivery and outcomes of primary percutaneous coronary intervention (PPCI). Furthermore, to compare clinical presentation and outcomes of patients with ST-segme...

The protective role of probiotics in sepsis-induced rats.

Oct 29, 2020

Probiotic ingestion is associated with an increase in intestinal flora of useful bacteria, which contributes to the known protective effects it has on the intestinal barrier and thereby reducing infec...

Platelet indices as a predictive marker in neonatal sepsis and respiratory distress in preterm prelabor rupture of membranes.

Oct 29, 2020

Preterm Prelabor rupture of membranes (PPROM) accompanies 2-3% of all pregnancies and 1/3rd of all preterm deliveries leading to intraamniotic infection, postpartum infections, sepsis along with perin...

Pediatric infection and sepsis in five age subgroups: single-center registry.

Oct 29, 2020

Sepsis is, worldwide, one of the leading causes of death among infants and children. Over the past two decades, mortality rates have declined due to advanced treatment options; however, the incidence ...

Mean Arterial Pressure and Discharge Outcomes in Severe Pediatric Traumatic Brain Injury.

Oct 29, 2020

Optimizing blood pressure is an important target for intervention following pediatric traumatic brain injury (TBI). The existing literature has examined the association between systolic blood pressure...

Predicting task performance from biomarkers of mental fatigue in global brain activity.

Oct 29, 2020

Objective Detection and early prediction of mental fatigue (i.e., shifts in vigilance), could be used to adapt neuromodulation strategies to effectively treat patients suffering from brain injury and ...

Sport Concussion Assessment Tool Symptom Inventory: Healthy and Acute Postconcussion Symptom Factor Structures.

Oct 29, 2020

Previous researchers have examined factor structures for common concussion symptom inventories. However, they failed to discriminate between the acute (<72 hours) and subacute (3 days-3 months) per...

Predictors and Outcomes of Hospitalization for Influenza: Real-World Evidence from the United States Medicare Population.

Oct 29, 2020

The purpose of this study was to identify predictors of initial hospitalization and describe the outcomes of high-risk patients hospitalized with influenza.Data were taken from the 5% national US Medi...

Regional protein expression changes within the left ventricle in a mouse model of dyssynchronous and resynchronized heart failure.

Oct 29, 2020

The biological mechanisms conveying the salutary effects of cardiac resynchronization therapy in heart failure remain elusive. We have recently developed a mouse model of heart failure with dyssynchro...

Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease.

Oct 29, 2020

Coronary angiography (CAG) sometimes shows nonobstructive coronary arteries in patients with suspected angina or acute coronary syndrome (ACS). The high prevalence of nonobstructive coronary artery di...

Comparing Revascularization Outcomes by Left Ventricular Dysfunction in Patients With Left Main Coronary Artery Disease

Oct 26, 2020

With evidence indicating that a large area of myocardium is jeopardized by left main coronary artery (LMCA) disease, LMCA disease could be associated with left ventricular (LV) dysfunction, which is s...

Non-invasive assessment of cerebral microvascular changes for predicting postoperative cerebral hyperperfusion after surgical revascularisation for moyamoya disease: an arterial spin labelling MRI study.

Oct 26, 2020

Cerebral hyperperfusion syndrome (CHPS) can result after anastomotic surgery as the reperfusion is established in chronically ischemic cerebral territories in patients of moyamoya disease (MMD). In th...

Identification of Cytochrome b-245, beta-chain gene mutations, and clinical presentations in Iranian patients with X-linked chronic granulomatous disease.

Oct 26, 2020

X-linked chronic granulomatous disease (X-CGD) is an immunodeficiency disorder caused by defects in the gp91 subunit that leads to life-threatening infections. We aimed to identify CYBB gene mutations...

SLy2-deficiency promotes B-1 cell immunity and triggers enhanced production of IgM and IgG antibodies against pneumococcal vaccine.

Oct 26, 2020

Despite the benefits of existing vaccines, Streptococcus pneumoniae is still responsible for the greatest proportion of respiratory tract infections around the globe, thereby substantially contributin...

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