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Critical Care General

Hemophagocytic lymphohistiocytosis in children with Chronic Granulomatous Disease - Single center experience from North India.

Dec 03, 2020

Chronic granulomatous disease (CGD) is an inherited defect in components of the NADPH oxidase complex that result in a potential life-threatening infective and non-infective complications. Hemophagocy...

Treatment of patients with glioma during the COVID-19 pandemic: what we learned and what we take home for the future.

Dec 03, 2020

Coronavirus disease 2019 (COVID-19) has changed the way in which cancer is treated. Patients with high-grade glioma (HGG) are believed to be in a vulnerable category. The aim of this study was to desc...

Acute Myocardial Infarction Biosensor: A Review From Bottom Up.

Dec 03, 2020

Acute myocardial infarction (AMI) is a cardiovascular disease that is produced due to a deficiency of oxygen generating irreversible damage in the heart muscle. In diagnosis, electrocardiogram (ECG) i...

Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Cefiderocol, a Parenteral Siderophore Cephalosporin, in Patients with Pneumonia, Bloodstream Infection/Sepsis, or Complicated Urinary Tract Infection.

Dec 03, 2020

Cefiderocol is a novel siderophore cephalosporin with antibacterial activity against Gramnegative bacteria including carbapenemresistant strains. The standard dosing regimen of cefiderocol is 2 g admi...

Outbreak of catheter-related Burkholderia cepacia sepsis acquired from contaminated ultrasonography gel: the importance of strengthening hospital infection control measures in low resourced settings.

Dec 03, 2020

This article reports the largest nosocomial outbreak of B. cepacia-related Hospital Acquired Infectios (HAIs) and the epidemiological investigations leading to identification of ultrasound gel as a di...

Gram-negative bacilli bacteremia: a 7 year retrospective study in a referral Brazilian tertiary-care teaching hospital.

Dec 03, 2020

. Bloodstream infection is one of the most frequent and challenging hospital-acquired infections and it is associated with high morbidity, mortality and additional use of healthcare resources. Bloodst...

Collegiate Athletes' Concussion Awareness, Understanding, and -Reporting Behaviors in Different Countries With Varying Concussion Publicity.

Dec 03, 2020

Concussions are a global public health concern, and education on the importance of self-reporting may not reach all athletes to the same degree around the world.To determine if differences were presen...

Mechanosensation in traumatic brain injury.

Dec 03, 2020

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is induced by a discrete event that applies extreme mechanical forces to the brain. This review describes how the ...

Local delivery of RhoA siRNA by PgP nanocarrier reduces inflammatory response and improves neuronal cell survival in a rat TBI model.

Dec 03, 2020

Traumatic brain injury (TBI) is a leading cause of death and disability with complex pathophysiology including prolonged neuroinflammation, apoptosis, and glial scar formation. The upregulation of Rho...

Effect of Yugengtongyu Granules in Patients with Stable Coronary Artery Disease on Reducing Adverse Cardiovascular Events: A Double-Blind Controlled Trial.

Dec 03, 2020

To evaluate the effect of Yugengtongyu granules on reducing the incidence of adverse cardiovascular events and improving quality of life (QOL) in patients with stable coronary artery disease (SCAD). ...

Systematic analysis of molecular mechanisms of heart failure through the pathway and network-based approach.

Dec 03, 2020

The molecular networks and pathways involved in heart failure (HF) are still largely unknown. The present study aimed to systematically investigate the genes associated with HF, comprehensively explor...

Transcatheter Mitral Valve Repair in Patients with Heart Failure: A Meta-Analysis.

Dec 03, 2020

Severe secondary mitral regurgitation (MR) is associated with poor prognosis in heart failure patients with left ventricular systolic dysfunction. Few observational and randomized controlled studies d...

The effect of bed-to-nurse ratio on hospital mortality of critically ill children on mechanical ventilation: a nationwide population-based study.

Dec 03, 2020

Despite the high workload of mechanical ventilation, there has been a lack of studies on the association between nurse workforce and mortality in mechanically ventilated patients. We evaluated the ass...

Pre-Stroke Glycemic Variability Estimated by Glycated Albumin Is Associated with Early Neurological Deterioration and Poor Functional Outcome in Prediabetic Patients with Acute Ischemic Stroke.

Dec 03, 2020

Whether glycemic variability prior to stroke increases the risk of stroke outcomes in prediabetic patients presenting with acute ischemic stroke is still unclear. We evaluated whether pre-stroke glyce...

Risk of Ischemic Stroke after an Inpatient Hospitalization for Transient Ischemic Attack in the United States.

Dec 03, 2020

A diagnosis of transient ischemic attack (TIA) must be followed by prompt investigation and rapid initiation of measures to prevent stroke. Prior studies evaluating the risk of stroke after TIA were c...

Estimating Shortages of Continuous Kidney Replacement Therapy During COVID-19

Dec 01, 2020

During the current COVID-19 pandemic, there has been a surge in patients requiring intensive care throughout the United States. “Early in the pandemic, US healthcare systems worked to increase the n...

Assessment of antıbıotıc resıstance of ınfectıous agents ın patıents wıth pneumonıa ın tertıary crıtıcal care unıt and effect on clınıcal outcomes.

Nov 30, 2020

The aim of this study was to determine the prevalence of the causative agents of multi-drug resistant bacteria in pneumonia and also evaluate their mortality rates in the intensive care unit (ICU).Thi...

National Current Care Guidelines for paediatric lower respiratory tract infections reduced the use of chest radiographs but local variations were observed.

Nov 30, 2020

Our aim was to evaluate the impact of the 2014 Finnish Current Care Guidelines for paediatric lower respiratory tract infections (LRTIs), particularly on taking of chest radiographs.This study used of...

RAC1 nitration at Y IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury.

Nov 30, 2020

Acute lung injury (ALI), a devastating illness induced by systemic inflammation e.g., sepsis or local lung inflammation e.g., COVID-19 mediated severe pneumonia, has an unacceptably high mortality and...

The management of non-culprit coronary lesions in patients with acute coronary syndrome.

Nov 30, 2020

About 50% of patients diagnosed with ST-segment elevation myocardial infarction have multivessel disease on coronary angiography. Recent evidence has shown that a staged percutaneous coronary interven...

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