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Critical Care General

Antimicrobial effects of nitric oxide in murine models of Klebsiella pneumonia.

Dec 24, 2020

Inhalation of nitric oxide (NO) exerts selective pulmonary vasodilation. Nitric oxide also has an antimicrobial effect on a broad spectrum of pathogenic viruses, bacteria and fungi.The aim of this stu...

Milk and Cookies

Dec 23, 2020

“Mr. Claus, tests indicate your blood is 95% milk and cookies.” ...

Transcranial Doppler Ultrasound Evidence of Active Cerebral Embolization in COVID-19.

Dec 21, 2020

To report six consecutive patients with confirmed coronavirus disease-2019 (COVID-19) who underwent Transcranial Doppler (TCD) ultrasonography evaluation for cerebral microemboli in the setting of sus...

Theaflavin ameliorates renal ischemia/reperfusion injury by activating the Nrf2 signalling pathway in vivo and in vitro.

Dec 21, 2020

Studies have demonstrated that oxidaive stress-induced apoptosis may be the main pathogenic mechanism of renal ischemia/reperfusion (I/R) injury. Theaflavin, a polyphenolic compound extracted from bla...

Acute Kidney Injury Associated with Late-Onset Neonatal Sepsis: A Matched Cohort Study.

Dec 21, 2020

To determine incidence and severity of acute kidney injury (AKI) within 7 days of sepsis evaluation and to assess AKI duration and the association between AKI and 30-day mortality. Retrospective, mat...

Immunomodulatory Low-Dose Whole-Lung Radiation for Patients with COVID-19-Related Pneumonia.

Dec 21, 2020

Phase I clinical trials have established low-dose, whole-lung radiotherapy (LD-RT) as safe for patients with COVID-19-related pneumonia. By focally dampening cytokine hyperactivation, LD-RT may improv...

Non-neonatal, Generalized Tetanus is still a highly fatal disease in Afghanistan; a case series study.

Dec 21, 2020

To describe clinical features and outcomes of a case series of adult tetanus which could be of great importance, illustrating still inadequacies in confronting this preventable disease.This study retr...

Efficacy and Safety of Adjunctive Cilostazol to Clopidogrel-Treated Diabetic Patients With Symptomatic Lower Extremity Artery Disease in the Prevention of Ischemic Vascular Events.

Dec 21, 2020

Background Type 2 diabetes mellitus is a risk factor for lower extremity arterial disease. Cilostazol expresses antiplatelet, anti-inflammatory, and vasodilator actions and improves the claudication i...

Long-Term Morbidity and Mortality after First and Recurrent Cardiovascular Events in the ARTPER Cohort.

Dec 21, 2020

Cardiovascular events are a major cause of mortality and morbidity worldwide. The risk of recurrence after a first cardiovascular event has been documented in the international literature, although no...

Does Prophylactic Ureteric Stenting at the Time of Colorectal Surgery Reduce the Risk of Ureteric Injury? A Systematic Review and Meta-analysis.

Dec 21, 2020

Cystoscopic placement of ureteric stents during colorectal surgery(CRS) may aid in the intraoperative identification of the ureters and thus prevent ureteric injury, but may also be associated with pr...

JNK selective inhibitor, IQ-1S, protects the mice against lipopolysaccharides-induced sepsis.

Dec 21, 2020

Sepsis is a severe systemic inflammatory response induced by infection. Innate immunity recognizes pathogen components such as lipopolysaccharides (LPS), and mediates the polarization of immune cells ...

Methylene blue in covid-19.

Dec 21, 2020

SARS-CoV-2 infection generally begins in the respiratory tract where it can cause bilateral pneumonia. The disease can evolve into acute respiratory distress syndrome and multi-organ failure, due to v...

Changes in Driving Behaviors After Concussion in Adolescents.

Dec 21, 2020

Although return to learn, exercise, and sports have evidence-based guidelines, there is limited research investigating return to driving after concussion. The purpose was to characterize and compare a...

The faster the better? Time to first CT scan after admission in moderate-to-severe traumatic brain injury and its association with mortality.

Dec 21, 2020

Fast acquisition of a first computed tomography (CT) scan after traumatic brain injury (TBI) is recommended. This study is aimed at investigating whether the length of the period preceding initial CT ...

Early intervention with levetiracetam prevents the development of cortical hyperexcitability and spontaneous epileptiform activity in two models of neurotrauma in rats.

Dec 21, 2020

This study examined the antiepileptogenic potential of the antiseizure drug (ASD) levetiracetam (LEV) using the in vitro traumatized-slice and in vivo controlled cortical impact (CCI) models of trauma...

Thoracic Endovascular Aortic Repair for Symptomatic Penetrating Aortic Ulcers and Intramural Hematomas is Associated with Poor Outcomes.

Dec 21, 2020

The natural history of penetrating aortic ulcers (PAU) and intramural hematomas (IMH) of the aorta is not well described. While repair is warranted for rupture, unremitting chest pain or growth, there...

Cardiac rehabilitation in women; comparison of enrollment, adherence and outcomes between heart failure and coronary artery disease.

Dec 21, 2020

There is paucity of data on cardiac rehabilitation (CR) enrollment and outcomes in women with heart failure (HF).In this retrospective analysis, we compared enrollment, adherence and outcomes between ...

Circadian influence on inflammatory response during cardiovascular disease.

Dec 21, 2020

Circadian rhythms follow a 24 h day and night cycle, regulate vital physiological processes, and are especially relevant to cardiovascular growth, renewal, repair, and remodeling. A recent flurry of ...

Short-term versus long-term dual antiplatelet therapy after drug-eluting stent implantation in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis.

Dec 21, 2020

The optimal duration of dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) is under controversial. The aim of the present systematic review and meta-analysis was to evalua...

How Helpful Is aEEG? Context and User Experience Matter.

Dec 17, 2020

 The aim of the study is to model amplitude-integrated electroencephalography (aEEG) utility to diagnose seizures in common clinical scenarios. Using reported neonatal seizure prevalence and aEEG ...

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