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Critical Care General

CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study.

Jan 04, 2021

Standard chemotherapy remains inadequate in metastatic pancreatic adenocarcinoma. Combining an agonistic CD40 monoclonal antibody with chemotherapy induces T-cell-dependent tumour regression in mice a...

The maternal leukocyte count at admission for labor is indicative of early maternal postpartum infectious morbidity and adverse neonatal outcome.

Jan 04, 2021

Investigate the association between maternal leukocyte count at admission for labor and postpartum infectious maternal morbidity (PPIM) following vaginal delivery.Retrospective cohort study, 2005-2017...

Field evaluation of a sing-dose bivalent vaccine of porcine circovirus type 2b and Mycoplasma hyopneumoniae.

Jan 04, 2021

The field efficacy of a bivalent vaccine containing porcine circovirus type 2b (PCV2b) and Mycoplasma hyopneumoniae was evaluated on three pig farms.Three pig farms were used, two of which had a histo...

Regular Use of VKA Prior to COVID-19 Associated with Lower 7-Day Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Cohort Study.

Jan 04, 2021

Vitamin K concentrations are inversely associated with the clinical severity of COVID-19. The objective of this cohort study was to determine whether the regular use of vitamin K antagonist (VKA) prio...

Occurence of Post-Traumatic Stress Symptoms, Anxiety and Depression in the Acute Phase of Transient Ischemic Attack and Stroke.

Jan 04, 2021

Rates of post-traumatic stress symptoms, anxiety and depression are increased in patients having experienced a transient ischemic attack (TIA) or stroke several months ago. However, data of psychiatri...

The Effect of Preoperative Renal Failure on Outcomes Following Infrainguinal Endovascular Interventions for Peripheral Arterial Disease.

Jan 04, 2021

To analyze the effect of a patient's renal failure status on acute outcomes after lower extremity endovascular interventions for peripheral artery disease.A retrospective analysis of the American Coll...

SARS-CoV-2-Induced ARDS Associates with MDSC Expansion, Lymphocyte Dysfunction, and Arginine Shortage.

Jan 04, 2021

The SARS-CoV-2 infection can lead to a severe acute respiratory distress syndrome (ARDS) with prolonged mechanical ventilation and high mortality rate. Interestingly, COVID-19-associated ARDS share bi...

Sepsis promotes gliogenesis and depletes the pool of radial glia like stem cells in the hippocampus.

Jan 04, 2021

Sepsis associated encephalopathy (SAE) is a major complication of patients surviving sepsis with a prevalence up to 70%. Although the initial pathophysiological events of SAE are considered to arise d...

Enhancing sensory acuity and balance function using near-sensory biofeedback-based perturbation intervention for individuals with traumatic brain injury.

Jan 04, 2021

Interventions addressing balance dysfunction after traumatic brain injury (TBI) only target compensatory aspects and do not investigate perceptual mechanisms such as sensory acuity.To evaluate the eff...

Secondary esophageal squamous cell carcinoma after hematopoietic stem cell transplantation.

Jan 04, 2021

We evaluated cases of esophageal squamous cell carcinoma (ESCC) that developed after allogeneic hematopoietic stem cell transplantation (allo-HSCT) at our institution.Allo-HSCT was performed in 1534 p...

Association of lower extremity injuries and injury mechanism with previous concussion history in adolescent athletes.

Jan 04, 2021

Determine the association between concussion and subsequent contact, non-contact, and overuse lower extremity (LE) injuries in a cohort of adolescent athletes. Secondarily, to identify this associatio...

Discrepancies between proxy estimates and patient reported, health related, quality of life: minding the gap between patient and clinician perceptions in heart failure.

Jan 04, 2021

Health related quality of life (HRQoL) is rarely routinely measured in the clinical setting. In the absence of patient reported data, clinicians rely on proxy and informal estimates to support clinica...

Effects of low-level tragus stimulation on endothelial function in heart failure with reduced ejection fraction.

Jan 04, 2021

Autonomic dysregulation in HFrEF plays a major role in endothelial dysfuction. Low level Tragus stimulation (LLTS) is a novel, non-invasive method of autonomic modulation.We enrolled 50 HFrEF patients...

Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii.

Jan 04, 2021

Fuzi, a well-known traditional Chinese medicine developed from the lateral roots of Aconitum carmichaelii Debx., has been widely used for the treatment of heart failure. In order to search for active ...

Prognostic value of intraplaque neovascularization detected by carotid Contrast-Enhanced Ultrasound in patients undergoing stress echocardiography.

Jan 04, 2021

Stress echocardiography (SE) is used for diagnosis and risk stratification of patients with known or suspected coronary artery disease (CAD). Contrast-enhanced ultrasound (CEUS) detects carotid intrap...

Risk factors for acute stroke-associated pneumonia and prediction of neutrophil-to-lymphocyte ratios.

Jan 04, 2021

This study aimed to analyze the risk factors for stroke-associated pneumonia (SAP) and assess the predictive effect of neutrophil-to-lymphocyte ratio (NLR) on acute SAP.The study included acute stroke...

Proteases and Delayed Wound Healing

Dec 31, 2020

The aim is understand Proteases and their inhibitors add to the harmony between extracellular lattice (ECM) corruption and affidavit, making a balance that is fundamental for the opportune and facilit...

Neutrophils and Wound Repair

Dec 31, 2020

Neutrophils are one of the most plentiful cells of the insusceptible framework and they are amazingly dynamic during the maintenance of cutaneous injuries. When all is said in done, the antimicrobial ...

Transforming Growth Factor Beta

Dec 31, 2020

This survey features the basic function of changing development factor beta (TGF-β)1–3 inside various periods of twisted mending, specifically, late-stage wound recuperating. It is additionally ess...

Lymphatic Anomaly and Gorham–Stout Disease

Dec 31, 2020

The objective is to understand Summed up lymphatic oddity and Gorham–Stout infection are amazingly uncommon illnesses with serious manifestations and helpless visualization. The etiology and clinica...

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