Obesity may be associated with better response to immune checkpoint blockade therapy
1. In this study, patients who were obese or overweight had better survival compared to normal...
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chronic-disease
No difference in outcomes between 3 minimally invasive surgical procedures for treatment of lumbar spinal stenosis
1. In this randomized clinical trial of 437 patients, no significant difference was observed in...
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Rapid antigen tests detect high SARS-CoV-2 levels during the Omicron surge
1. Rapid antigen tests detected persons with high SARS-CoV-2 levels, enabling rapid response to...
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Examining associations between physical activity and the risk of disabling dementia in older adults
1. This large, prospective cohort study from Japan demonstrated an inverse association between the...
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Cessation of aspirin in older adults not associated with adverse health effects
1. Aspirin cessation in older adults led to increased cardiovascular disease events, though not...
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Changes in opioid or nonopioid pain treatments not attributable to state opioid prescribing laws
1. No changes in opioid or nonopioid pain prescribing patterns were attributable to state laws. 2....
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Interatrial shunt device not effective in patients with symptomatic heart failure
1. There was no significant difference in the primary composite endpoint between the interatrial...
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Liposomal amphotericin B noninferior to standard treatment for cryptococcal meningitis
1. Single-dose liposomal amphotericin B followed by flucytosine and fluconazole was non-inferior...
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Trastuzumab deruxtecan associated with lower risk of metastatic breast cancer progression
1. Compared to trastuzumab emtansine, trastuzumab deruxtecan is associated with a lower risk of...
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Darolutamide improves overall survival in patients with hormone-sensitive prostate cancer
1. Patients with hormone-sensitive prostate cancer receiving darolutamide, an androgen-receptor...
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2 Minute Medicine Rewind March 28th, 2022
Rapid Point-of-Care Genotyping to Avoid Aminoglycoside-Induced Ototoxicity in Neonatal Intensive...
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Wellness Check: Spirituality
2 Minute Medicine is pleased to announce that we are launching Wellness Check, a new series...
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Homologous and heterologous Covid-19 booster vaccines are effective in adults
1. Homologous and heterologous booster vaccines had an acceptable safety profile in adults who...
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Very low birth weight associated with brain volume differences in adulthood
1. In a cohort of about 80 adults who were born with very low birth weight (VLBW), total brain...
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Vaccine booster after Johnson & Johnson-Janssen priming are safe and immunogenic
1. Both the Johnson & Johnson-Janssen (JJJ) and mRNA boosters provided an acceptable safety...
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Cardiosphere-derived cell therapy slows disease progression in Duchenne muscular dystrophy
1. Cardiosphere-derived cell therapy (CAP-1002) slowed loss of upper limb function by 71% compared...
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Donidalorsen reduces attacks in patients with C1 inhibitor deficiency
1. Patients with hereditary angioedema receiving donidalorsen showed reduced rates of angioedema...
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mRNA vaccine boosters less effective against the omicron variant in Qatar
1. mRNA booster vaccines for Covid-19 were highly effective against delta infection but less...
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Increased risk of intracranial hemorrhage with aspirin and unfractionated heparin use for endovascular stroke treatment
1. Ischemic stroke patients assigned to aspirin-only, heparin-only, or both, had worse Modified...
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Valoctocogene roxaparvovec gene therapy efficacious for hemophilia A treatment
1. The adeno-associated virus 5 (AAV5)-based gene therapy, valoctocogene roxaparvovec...
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