chronic-disease

1. In this study, counselors reported that patients would be more likely to access buprenorphine treatment if they had access to greater social resources, such as housing or internet. 2. Counselors also report that increased screening at intake about psychosocial factors would be helpful. Evidence Rating Level: 3 (Average) One of the current national public […]

1. In patients with gout and chronic kidney disease, the initiation of allopurinol was not associated with increased mortality. 2. In patients with gout and chronic kidney disease, dose escalation of allopurinol nor achieving target serum urate levels was associated with increased mortality. Evidence Rating Level: 2 (Good) Study Rundown: Serum urate (SU) lowering medications […]

1. In this cross-sectional study, there was a 57% increase in new-onset Type 1 Diabetes diagnoses in children at a tertiary care hospital during a 12-month period of the COVID-19 pandemic. 2. Incidence of diabetic ketoacidosis on presentation increased from 41% to 50%. Evidence Rating Level: 2 (Good) Study Rundown: Type 1 diabetes (T1D) is […]

1. Patients hospitalized with COVID-19 receiving at least one dose of molnupiravir did not show reduced mortality compared to patients receiving placebo treatment. 2. Molnupiravir was not associated with any dose-limiting side effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Molnupiravir is a small molecule that interferes with the viral genome replication process in RNA […]

1. The use of a neoadjuvant gemcitabine-based chemoradiotherapy before surgery and adjuvant gemcitabine increased the overall survival rate when compared to upfront surgery and adjuvant gemcitabine. 2. Patients in the neoadjuvant chemoradiotherapy groups had more R0 resections than patients receiving upfront surgery and adjuvant gemcitabine. Evidence Rating Level: 1 (Excellent) Study Rundown: Past randomized control […]

1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0 genotype patients. 2. The gene therapy resulted in a total hemoglobin level sufficient for transfusion independence in these patients. Evidence Rating Level: 1 (Excellent) Study Rundown: β-thalassemia is caused by β-globin gene mutations, leading to […]

1. GLP-1 receptor agonists, such as semaglutide, and phentermine-topiramate were shown to cause the greatest percent decrease in body weight. 2. GLP-1 receptor agonists, phentermine-topiramate, and naltrexone-bupropion were also associated with increased adverse effects. Evidence Rating Level: 1 (Excellent) Study Rundown: Over two-thirds of Americans are considered to be in the overweight or obese body-mass […]

1. This secondary analysis of the SPRINT cohort study demonstrated that type 2 and 4 angiotensin II receptor (AT2R/AT4R)-stimulating antihypertensives decreased the risk of amnestic mild cognitive impairment or probable dementia by approximately 25% compared to AT2R/AT4R-inhibiting antihypertensives. Evidence Rating Level: 2 (Good) Study Rundown: Hypertension is a well-known, highly prevalent, modifiable risk for dementia. […]

1. Low quality evidence demonstrates that knee extensor muscle weakness increased the odds of symptomatic and radiographic knee osteoarthritis in men and women. 2. In women with a previous knee injury, low quality evidence shows no association between knee extensor muscle weakness and symptomatic and radiographic tibiofemoral osteoarthritis. Evidence Rating Level: 2 (Good) Knee osteoarthritis […]