ACKR1 variant increases risk of azathioprine-related hematopoietic toxicity
1. Patients with the ACKR1 variant (CC genotype) had an elevated risk of azathioprine...
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chronic-disease
Heavy smoking is associated with visual field loss in glaucoma
1. In a cohort of about 500 eyes with primary open-angle glaucoma (POAG), higher smoking intensity...
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Post-operative opioids at discharge increase adverse events without improving pain management
1. There was no significant difference in pain reduction among patients in the opioid and...
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United States medical cannabis registration increased significantly between 2016 and 2020
1. Registration for medical cannabis increased 4.5 times from 2016 to 2020 in the United States,...
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Fazirsiran reduces Z-AAT protein production in alpha1-antitrypsin deficiency
1. Fazirsiran is associated with a signifcant reduction of Z-AAT protein concentration in the...
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2 Minute Medicine Rewind June 27, 2022
Multispecies Probiotic for the Prevention of Antibiotic-Associated Diarrhea in Children: A...
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High tumour mutation burden in NSCLC associated with improved clinical outcomes of PD-L1 blockade across PD-L1 expression subgroups
1. High tumour mutation burden levels were associated with improvements in objective response...
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Treatment of anal high-grade squamous intraepithelial lesions can reduce rates of progression to invasive anal cancer.
1. The rate of progression was 57% lower in the group receiving anal HSIL treatment as compared to...
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Human papillomavirus (HPV) vaccination rates have increased in recent years
1. Between 2015 and 2020, human papillomavirus vaccination (HPV) rates in the United States...
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CYP2C19 loss-of-function carriers have modest benefit from ticagrelor and aspirin following cerebrovascular event: CHANCE-2 Trial
1. Patients carrying the CYP2C19 loss-of-function mutation (C-LOF), who had experienced a minor...
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Children with complex chronic conditions represent approximately half of postoperative deaths in children undergoing tonsillectomy in 5 US states
1. Among children undergoing tonsillectomy, the rate of postoperative death was 7 per 100 000...
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Incidence of Kawasaki disease found to be lower during the COVID-19 pandemic in the United States
1. This multicenter cohort study of 3922 children with Kawasaki disease (KD) demonstrated that...
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Vitamin and mineral supplementation associated with minimal to no benefit in the primary preventing of cardiovascular disease and cancer – US Preventative Services Task Force
1. Vitamin and mineral supplementation was associated with minimal to no benefit in preventing...
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Gut microbiota signatures of long-term and short-term plant-based dietary pattern and cardiometabolic health
1. Long-term plant-based diet was associated with more variance in microbial structure and future...
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Circulating Tumour DNA Analysis reduced adjuvant chemotherapy use while not compromising recurrence-free survival in stage II colon cancer
1. The circulating tumour DNA-guided approach was non-inferior to the standard clinicopathological...
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Social risk factors associated with increased pediatric emergency department utilization
1. In a large cohort of children screened for risk factors such as food insecurity and housing...
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Rare APOE missense variants V236E and R251G associated with substantial reduction in risk of Alzheimer disease
1. APOE ε3 (V236E) and APOE ε4 (R251G), 2 rare missense genetic variants, both had a substantial...
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Effectiveness of a digital intervention versus alcohol information for online help-seekers in Sweden
1. Among a group of risky drinkers seeking online help in Sweden, a digital alcohol intervention...
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Decline in gait speed paired with domain-specific cognition decline may be a useful screening assessment for dementia
1. A decline in gait speed paired with domain-specific cognitive decline proved to be strongly...
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Subacromial balloon spacer not effective for management of irreparable rotator cuff tears
1. The control group (debridement-only) reported better clinical outcomes at 12 months compared to...
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